Results 21 to 30 of about 3,657 (146)

Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis [PDF]

, 2023
Background: Primaquine is used to eliminate Plasmodium vivax hypnozoites, but its optimal dosing regimen remains unclear. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy and tolerability of different
Lacerda, Marcus VG, Chu, Cindy, Daher, André, Cui, Liwang, Llanos-Cuentas, Alejandro, Pereira, Dhelio B, Guerin, Philippe J, Vieira Camacho, Jose, Abreha, Tesfay, Commons, Robert J, Rijal, Komal R, Taylor, Walter RJ, Grigg, Matthew J, Simpson, Julie A, Awab, Ghulam R, Lidia, Kartini, Hwang, Jimee, Pukrittayakamee, Sasithon, Ladeia-Andrade, Simone, Longley, Rhea J, Thanh, Pham V, Pasaribu, Ayodhia P, Sutanto, Inge, Barber, Bridget E, Rajasekhar, Megha, Gonzalez-Ceron, Lilia, Baird, John, Price, Ric N, Thriemer, Kamala, Watson, James, White, Nicholas, Karunajeewa, Harin, Zuluaga-Idarraga, Lina M, Edler, Peta   +33 more
core   +1 more source

Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data

BMC Medicine, 2022
Background In 2012, the World Health Organization (WHO) recommended single low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum gametocytocide to artemisinin-based combination therapy (ACT) without glucose-6-phosphate ...
Kasia Stepniewska, Elizabeth N. Allen, Georgina S. Humphreys, Eugenie Poirot, Elaine Craig, Kalynn Kennon, Daniel Yilma, Teun Bousema, Philippe J. Guerin, Nicholas J. White, Ric N. Price, Jaishree Raman, Andreas Martensson, Richard O. Mwaiswelo, Germana Bancone, Guido J. H. Bastiaens, Anders Bjorkman, Joelle M. Brown, Umberto D’Alessandro, Alassane A. Dicko, Badria El-Sayed, Salah-Eldin Elzaki, Alice C. Eziefula, Bronner P. Gonçalves, Muzamil Mahdi Abdel Hamid, Akira Kaneko, Simon Kariuki, Wasif Khan, Titus K. Kwambai, Benedikt Ley, Billy E. Ngasala, Francois Nosten, Joseph Okebe, Aaron M. Samuels, Menno R. Smit, Will J. R. Stone, Inge Sutanto, Feiko Ter Kuile, Roger C. Tine, Alfred B. Tiono, Chris J. Drakeley, Roly Gosling, Andy Stergachis, Karen I. Barnes, Ingrid Chen   +44 more
doaj   +1 more source

Effects of co-treatment of Plasmodium berghei-infected mice with aqueous extract of Ocimum gratissimum leaves and primaquine on glucose-6-phosphate dehydrogenase activity, hematological, and antioxidant parameters

Journal of Ayurveda and Integrative Medicine, 2022
Background: It has been observed that most malaria patients especially G6PD-deficient patients usually experience oxidative stress and severe anemia when treated with primaquine.
Shedrach Kanu C, Chinyere Aloke, Nwabueze Elom I, Chinedum Eleazu O   +3 more
doaj   +1 more source

Optimal timing of primaquine to reduce Plasmodium falciparum gametocyte carriage when co-administered with artemether–lumefantrine

Malaria Journal, 2020
Background Primaquine is an important gametocytocidal drug that is combined with conventional malaria treatment for prevention of Plasmodium falciparum malaria transmission.
Seif Shekalaghe, Dominic Mosha, Ali Hamad, Thabit A. Mbaga, Michael Mihayo, Teun Bousema, Chris Drakeley, Salim Abdulla   +7 more
doaj   +1 more source

Increased primaquine total dose prevents Plasmodium vivax relapses in patients with impaired CYP2D6 activity: report of three cases

Malaria Journal, 2021
Background The relapsing nature of Plasmodium vivax infection is a major barrier to its control and elimination. Factors such as adequate dosing, adherence, drug quality, and pharmacogenetics can impact the effectiveness of radical cure of P.
Anielle de Pina-Costa, Ana Carolina Rios Silvino, Edwiges Motta dos Santos, Renata Saraiva Pedro, José Moreira, Gabriela Liseth Umana, Ana Danielle Tavares da Silva, Otília Helena Lupi da Rosa Santos, Karina Medeiros de Deus Henriques, Cláudio Tadeu Daniel-Ribeiro, Patrícia Brasil, Tais Nobrega Sousa, André M. Siqueira   +12 more
doaj   +1 more source

Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry

Malaria Journal, 2022
Background The enantiomers of the 8-aminoquinoline anti-malarial primaquine have different pharmacological properties. Development of an analytical method for simultaneous quantification of the enantiomers of primaquine and its metabolite ...
Warunee Hanpithakpong, Nicholas P. J. Day, Nicholas J. White, Joel Tarning   +3 more
doaj   +1 more source

5-Phenoxy Primaquine Analogs and the Tetraoxane Hybrid as Antimalarial Agents

Molecules, 2021
The rapid emergence of drug resistance to the current antimalarial agents has led to the urgent need for the discovery of new and effective compounds.
Somruedee Jansongsaeng, Nitipol Srimongkolpithak, Jutharat Pengon, Sumalee Kamchonwongpaisan, Tanatorn Khotavivattana   +4 more
doaj   +1 more source

Ethics, economics, and the use of primaquine to reduce falciparum malaria transmission in asymptomatic populations. [PDF]

, 2014
Yoel Lubell and colleagues consider ethical and economic perspectives on mass drug administration of primaquine to limit transmission of P. falciparum malaria.
Richard J Maude, Maude, RJ, Arjen Dondorp, Michael Parker, Shunmay Yeung, Drake, Tom, Lisa White, White, Lisa, White, Nicholas J, Parker, M, Yeung, Shunmay, Day, NP, Nicholas P J Day, Drake, T, Yeung, S, Yoel Lubell, Day, Nicholas PJ, Varadan, S, White, L, Dondorp, A, Lubell, Y, Varadan, Sheila, Parker, Michael, Cheah, PY, Sheila Varadan, Nicholas J White, Dondorp, Arjen, Tom Drake, Day, Nicholas, White, NJ, Cheah, Phaik Yeong, White, Nicholas, Maude, Richard J, Lubell, Yoel, Phaik Yeong Cheah   +34 more
core   +1 more source

Primaquine in vivax malaria: an update and review on management issues

Malaria Journal, 2011
Primaquine was officially licensed as an anti-malarial drug by the FDA in 1952. It has remained the only FDA licensed drug capable of clearing the intra-hepatic schizonts and hypnozoites of Plasmodium vivax.
Fernando Deepika, Rodrigo Chaturaka, Rajapakse Senaka   +2 more
doaj   +1 more source

Single dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission in Cambodia: An open-label randomized trial. [PDF]

PLoS ONE, 2017
BACKGROUND:Single low dose primaquine (SLD PQ, 0.25mg/kg) is recommended in combination with artemisinin-based combination therapy (ACT) as a gametocytocide to prevent Plasmodium falciparum transmission in areas threatened by artemisinin resistance.
Jessica T Lin, Chanthap Lon, Michele D Spring, Somethy Sok, Soklyda Chann, Mali Ittiverakul, Worachet Kuntawunginn, Mok My, Kheangheng Thay, Rifat Rahman, Sujata Balasubramanian, Mengchuor Char, Charlotte A Lanteri, Panita Gosi, Ratawan Ubalee, Steven R Meshnick, David L Saunders   +16 more
doaj   +1 more source