Results 41 to 50 of about 8,118 (161)

Safety and efficacy of primaquine in patients with Plasmodium vivax malaria from South Asia: a systematic review and individual patient data meta-analysis

BMJ Global Health, 2023
Background The optimal dosing of primaquine to prevent relapsing Plasmodium vivax malaria in South Asia remains unclear. We investigated the efficacy and safety of different primaquine regimens to prevent P.
Philippe J Guérin, Kavitha Saravu, Julie A Simpson, Bipin Adhikari, Komal Raj Rijal, Prakash Ghimire, Mark Rowland, Sasithon Pukrittayakamee, Amit Sharma, Manju Rahi, Praveen K Bharti, Ric N Price, Megha Rajasekhar, Toby Leslie, Reena Verma, Rishikesh Kumar, Sauman Singh-Phulgenda, Robert J Commons, Apoorv Gupta, Nitika, Kamala Thriemer, Mohammad Shafiul Alam, Wasif A Khan, Benedikt Ley, Alejandro Llanos-Cuentas   +24 more
doaj   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, Volume 13, Issue 40, 17 July 2026.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Access to primaquine in the last mile: challenges at the service delivery points in pre-elimination era, Myanmar

Tropical Medicine and Health, 2018
Background Alongside monitoring of the disease burden, the successful move towards malaria elimination relies on the readiness of the health care delivery system.
Kay Thwe Han, Khin Thet Wai, Tin Oo, Aung Thi, Zayar Han, Daw Kyin Hla Aye, Aung Ye Naung Win, Jetsumon Prachumsri   +7 more
doaj   +1 more source

Strong Cross‐Reactivity of Anti–Plasmodium falciparum pLDH Monoclonal Antibodies With Plasmodium malariae pLDH in the Abbott Bioline Malaria Ag P.f/P.f/P.v Rapid Diagnostic Test

Tropical Medicine &International Health, Volume 31, Issue 7, Page 944-952, July 2026.
ABSTRACT Objectives This study aimed to describe the cross‐reactivity of the Abbott Bioline Malaria Ag P.f/P.f/P.v rapid diagnostic test, designed to detect Plasmodium falciparum and P. vivax , with other Plasmodium species, based on the detection of parasite lactate dehydrogenase enzymes.
Gabriel Montoia, Maria Carmen Arroyo Sanchez, Giselle Lima‐Cooper, Maria de Lourdes Rego Neves Farinas, Juliana Inoue, Silvia Maria Di Santi   +5 more
wiley   +1 more source

The reality of using primaquine

Malaria Journal, 2010
Background Primaquine is currently the only medication used for radical cure of Plasmodium vivax infection. Unfortunately, its use is not without risk. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency have an increased susceptibility to ...
Bancone Germana, Burgoine Kathy L, Nosten François   +2 more
doaj   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, Volume 604, Issue 13, Page 5355-5377, 1 July 2026.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Analysis of the effect of primaquine dose on efficacy, safety, and tolerability in patients with Plasmodium vivax malaria in Ethiopia: a systematic review and individual patient data meta-analysis

Malaria Journal
Background The 8-aminoquinoline antimalarials are used to prevent P. vivax relapses. Recent evidence suggests high total dose primaquine (7 mg/kg) provides optimal efficacy, however, many countries, including Ethiopia, use low total dose primaquine (3.5 ...
Tamiru Shibiru Degaga, Kamala Thriemer, Megha Rajasekhar, Tesfay Abreha, Ashenafi Assefa, Nicholas M. Douglas, Endalamaw Gadisa, Asrat Hailu, Jimee Hwang, Gavin C. K. W. Koh, Marcus V. G. Lacerda, Alejandro Llanos-Cuentas, Daniel Abebe Mekonnen, Julie A. Simpson, Fitsum G. Tadesse, Walter R. J. Taylor, Lorenz von Seidlein, Adugna Woyessa, Asnakew K. Yeshiwondim, Daniel Yilma, Ric N. Price, Gudissa Assefa Bayissa, Robert J. Commons   +22 more
doaj   +1 more source

Optimally timing primaquine treatment to reduce Plasmodium falciparum transmission in low endemicity Thai-Myanmar border populations

Malaria Journal, 2009
Background Effective malaria control has successfully reduced the malaria burden in many countries, but to eliminate malaria, these countries will need to further improve their control efforts.
Hungerford Laura L, Maneeboonyang Wanchai, Thanyavanich Nipon, Yimsamran Surapon, Singhasivanon Pratap, Klein Eili Y, Lawpoolsri Saranath, Maguire James H, Smith David L   +8 more
doaj   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor

Acta Crystallographica Section F, Volume 82, Issue 6, Page 194-200, June 2026.
The production, crystallization and 1.8 Å resolution crystal structure of macrophage migratory inhibitory factor from P. vivax are reported.Plasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory ...
Aryana Nair, Matthew Lin, Arav Srivastava, Lijun Liu, Anne Cooper, Kevin Battaile, Elizabeth Harmon, Peter J. Myler, Bart L. Staker, Scott Lovell, Graham Chakafana, Oluwatoyin A. Asojo   +11 more
wiley   +1 more source