Results 61 to 70 of about 8,118 (161)

Ultrastructural alterations in Schistosoma mansoni juvenile and adult male worms after in vitro incubation with primaquine

Memorias do Instituto Oswaldo Cruz
BACKGROUND Praziquantel has been cited as the only drug for treating schistosomiasis. However, concerns over drug resistance have encouraged the search for novel drug leads.
Reem Osama A Kamel, Fatma El-Zahraa Anwar Bayaumy   +1 more
doaj   +1 more source

Genomic Insights Into Host Shifts Between Plasmodium vivax and Plasmodium simium in Latin America

Evolutionary Applications, Volume 19, Issue 3, March 2026.
ABSTRACT Malaria in Latin America is largely caused by Plasmodium vivax, but the closely related monkey parasite Plasmodium simium has recently been observed in humans, thus raising new public health concerns. By screening 719 monkey samples from five Latin America countries, we identified 23 Plasmodium‐positives.
Margaux J. M. Lefebvre, Fanny Degrugillier, Céline Arnathau, Camila González, Silvia Rondón, Andrés Link, Andrea Chaves, Julio A. Benavides, Aline Alves Scarpellini Campos, Edmilson dos Santos, Rosana Huff, Cláudia Maria Dornelles da Silva, Ezequiel Vanderhoeven, Benoit De Thoisy, Michael C. Fontaine, Franck Prugnolle, Virginie Rougeron   +16 more
wiley   +1 more source

Infection of Anopheles darlingi fed on patients infected with Plasmodium vivax before and during treatment with chloroquine plus primaquine in Costa Marques, Rondônia, Brazil

Memorias do Instituto Oswaldo Cruz, 1992
Five patients with asexual and sexual parasites of Plasmodium vivax were treated orally with 600 mg chloroquine diphosphate (hour 0) followed with 300 mg at 8, 24 and 48 h later.
Terry A. Klein, Mauro S. Tada, Jose B. P. Lima, Amazonia Toda Tang   +3 more
doaj   +1 more source

Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon

Brazilian Journal of Infectious Diseases, 2010
This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine.
Wilson M. Ramos Júnior, José F.J. Sardinha, Mônica R.F. Costa, Marli S. Santana, Maria G.C. Alecrim, Marcus V.G. Lacerda   +5 more
doaj   +1 more source

Burden and clinical characteristics of recurrent Plasmodium vivax infections, and impact of primaquine for radical cure: a systematic scoping review in India

Frontiers in Malaria
BackgroundIndia accounts for the bulk of Plasmodium vivax burden in South East Asia. Primaquine (PQ) is the only currently available drug for treating relapses in P. vivax malaria.
Loick Pradel Kojom Foko, Vineeta Singh
doaj   +1 more source

Antiproliferative evaluation of various aminoquinoline derivatives

Acta Pharmaceutica, 2019
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f.
Zorc Branka, Rajić Zrinka, Perković Ivana   +2 more
doaj   +1 more source

Primaquine-induced Methemoglobinemia with Normal G6PD Levels

Indian Journal of Medical Specialities
Methemoglobinemia is a rare but serious condition characterized by elevated methemoglobin levels, which impairs oxygen delivery to tissues. It can be induced by various factors, including medications.
Ankur Sharma, Prashant Bhalekar, Ashutosh Pakale, Sudeep Jain   +3 more
doaj   +1 more source

Spectrophotometric Determination of Primaquine by Coupling with Diazotized p-Nitroaniline Application to Pharmaceutical Formulations [PDF]

Pakistan Journal of Analytical & Environmental Chemistry, 2011
A simple spectrophotometric method for the determination of primaquine phosphate has been developed. The method is based on the coupling reaction of primaquine phosphate in acidic medium with diazotized p-nitroaniline, to form a yellow-orange water ...
Ferial Mahmood El-Samman, Enam Ahmed Hamdoon, Asma Natiq Al-Irhayim   +2 more
doaj  

Population pharmacokinetics of primaquine and its metabolites in African males

Malaria Journal
Background Primaquine (PQ) is the prototype 8-aminoquinoline drug, a class which targets gametocytes and hypnozoites. The World Health Organization (WHO) recommends adding a single low dose of primaquine to the standard artemisinin-based combination ...
Palang Chotsiri, Almahamoudou Mahamar, Halimatou Diawara, Pius S. Fasinu, Kalifa Diarra, Koualy Sanogo, Teun Bousema, Larry A. Walker, Joelle M. Brown, Alassane Dicko, Roly Gosling, Ingrid Chen, Joel Tarning   +12 more
doaj   +1 more source

A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border.

PLOS Global Public Health
BackgroundThe countries within the Greater Mekong Region of Southeast Asia have pledged to eliminate malaria by 2030. Elimination of Plasmodium vivax malaria is challenging as it requires radical cure to prevent relapse.
April T Ansari, Ko Ko Aung, Htun Htun Win, Candy Beau, Be Nu, Nay Lin Soe, Klay Htoo, Thida San, Tha Gay Wah, Arunrot Keereevijit, Aung Pyae Phyo, Kesinee Chotivanich, Nicholas J White, François Nosten, Ahmar H Hashmi, Cindy S Chu   +15 more
doaj   +1 more source