Results 61 to 70 of about 3,657 (146)

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 731-744, September 2026.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Safety and efficacy of primaquine in patients with Plasmodium vivax malaria from South Asia: a systematic review and individual patient data meta-analysis

BMJ Global Health, 2023
Background The optimal dosing of primaquine to prevent relapsing Plasmodium vivax malaria in South Asia remains unclear. We investigated the efficacy and safety of different primaquine regimens to prevent P.
Philippe J Guérin, Kavitha Saravu, Julie A Simpson, Bipin Adhikari, Komal Raj Rijal, Prakash Ghimire, Mark Rowland, Sasithon Pukrittayakamee, Amit Sharma, Manju Rahi, Praveen K Bharti, Ric N Price, Megha Rajasekhar, Toby Leslie, Reena Verma, Rishikesh Kumar, Sauman Singh-Phulgenda, Robert J Commons, Apoorv Gupta, Nitika, Kamala Thriemer, Mohammad Shafiul Alam, Wasif A Khan, Benedikt Ley, Alejandro Llanos-Cuentas   +24 more
doaj   +1 more source

Predictive Modelling of Climate‐Driven Malaria Transmission for Optimal Control Using a Coupled SEIR–SEI and GIS Framework

Public Health Challenges, Volume 5, Issue 3, September 2026.
A climate‐sensitive SEIR–SEI model coupled with GIS mapping across Zimbabwe's Mberengwa District projected a 4‐fold rise in malaria transmission under mid‐century warming. However, it showed that indoor residual spraying at 80% coverage can still achieve elimination, prioritising five high‐risk catchments for climate‐resilient intervention.
Tafadzwa Chivasa, Mlamuli Dhlamini, Auther Maviza, Wilfred Njabulo Nunu   +3 more
wiley   +1 more source

Primaquine for malaria treatment.

, 2018
Primaquine for malaria treatment.
Elizabeth A. Ashley (237173), Nicholas J. White (35779), Judith Recht (3750991)   +2 more
core   +1 more source

Primaquine [PDF]

Reactions Weekly, 2020
  +6 more sources

Single Low Dose Primaquine (0.25 mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects. [PDF]

PLoS ONE, 2016
Primaquine is the only drug consistently effective against mature gametocytes of Plasmodium falciparum. The transmission blocking dose of primaquine previously recommended was 0.75 mg/kg (adult dose 45 mg) but its deployment was limited because of ...
Germana Bancone, Nongnud Chowwiwat, Raweewan Somsakchaicharoen, Lalita Poodpanya, Paw Khu Moo, Gornpan Gornsawun, Ladda Kajeechiwa, May Myo Thwin, Santisuk Rakthinthong, Suphak Nosten, Suradet Thinraow, Slight Naw Nyo, Clare L Ling, Jacher Wiladphaingern, Naw Lily Kiricharoen, Kerryn A Moore, Nicholas J White, Francois Nosten   +17 more
doaj   +1 more source

A Review on Green Synthetic Approaches in the Development of Quinoline Analogues

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This review highlights recent advances in environmentally friendly approaches, including metal‐free systems, solvent‐free approaches, microwave, and ultrasonic‐assisted techniques, organo‐ and biocatalysis, ionic liquids, nanoparticle catalysis, electrochemical, and photocatalytic strategies for the synthesis of quinoline scaffolds.
Demis Zelelew, Ajay Bissessur, Parvesh Singh, Hogantharanni Govender   +3 more
wiley   +1 more source

Self-gelling primaquine-gum arabic conjugate: An injectable controlled delivery system for primaquine

, 2007
Primaquine, an 8-aminoquinoline, forms a cross-linked gel with periodate-oxidized gum arabic rapidly by simply mixing the drug with the oxidized polysaccharide due to Schiff's base formation between the two amino groups of primaquine and the aldehyde ...
Nishi, K. K., Jayakrishnan, A.
core   +2 more sources

Access to primaquine in the last mile: challenges at the service delivery points in pre-elimination era, Myanmar

Tropical Medicine and Health, 2018
Background Alongside monitoring of the disease burden, the successful move towards malaria elimination relies on the readiness of the health care delivery system.
Kay Thwe Han, Khin Thet Wai, Tin Oo, Aung Thi, Zayar Han, Daw Kyin Hla Aye, Aung Ye Naung Win, Jetsumon Prachumsri   +7 more
doaj   +1 more source

Methaemoglobinaemia: From pathophysiology to contemporary clinical management

British Journal of Haematology, Volume 209, Issue 3, Page 900-910, September 2026.
Summary Methaemoglobin (MetHb) is an oxidised form of haemoglobin (Hb) unable to bind oxygen. Raised levels of MetHb reduce the blood's oxygen‐carrying capacity, causing potentially severe hypoxaemia and possible death. The condition arises from three main pathologies: mutations in globin genes causing Haemoglobin‐M, inherited deficiency of the enzyme ...
Alexander J. Twine, David C. Rees
wiley   +1 more source