Results 71 to 80 of about 3,657 (146)

Analysis of the effect of primaquine dose on efficacy, safety, and tolerability in patients with Plasmodium vivax malaria in Ethiopia: a systematic review and individual patient data meta-analysis

Malaria Journal
Background The 8-aminoquinoline antimalarials are used to prevent P. vivax relapses. Recent evidence suggests high total dose primaquine (7 mg/kg) provides optimal efficacy, however, many countries, including Ethiopia, use low total dose primaquine (3.5 ...
Tamiru Shibiru Degaga, Kamala Thriemer, Megha Rajasekhar, Tesfay Abreha, Ashenafi Assefa, Nicholas M. Douglas, Endalamaw Gadisa, Asrat Hailu, Jimee Hwang, Gavin C. K. W. Koh, Marcus V. G. Lacerda, Alejandro Llanos-Cuentas, Daniel Abebe Mekonnen, Julie A. Simpson, Fitsum G. Tadesse, Walter R. J. Taylor, Lorenz von Seidlein, Adugna Woyessa, Asnakew K. Yeshiwondim, Daniel Yilma, Ric N. Price, Gudissa Assefa Bayissa, Robert J. Commons   +22 more
doaj   +1 more source

Cyclodextrins as Chiral Selectors in Capillary Electrophoresis—Recent Developments in Understanding Analyte Complexation and Applications in Pharmaceutical Analysis

ELECTROPHORESIS, Volume 47, Issue 8, Page 696-712, August 2026.
Cyclodextrins are the most often applied chiral selectors in CE enantioseparations. In combination with NMR spectroscopy and molecular modeling, studies for an understanding of chiral recognition underlying enantioseparations have been performed.
Gerhard K. E. Scriba
wiley   +1 more source

Primaquine pharmacokinetics in lactating women and breastfed infant exposures [PDF]

, 2018
Primaquine is the only drug providing radical cure of Plasmodium vivax malaria. It is not recommended for breastfeeding women as it causes hemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals, and breast milk excretion and thus ...
White, Nicholas J., Cindy S Chu, Chu, CS, Hilda, N, Verena I Carrara, Bancone, G, Germana Bancone, Mary Ellen Gilder, Pratap Singhasivanon, Tarning, J, Nosten, F, Warunee Hanpithakphong, Hanpithakphong, W, Tarning, Joel, François Nosten, Rose McGready, Gilder, ME, Singhasivanon, P, Carrara, VI, McGready, R, Joel Tarning, Hoglund, Richard, Nicholas J White, Chu, Cindy S., Naw Hilda, White, NJ, Richard M Hoglund, Hoglund, RM, Htun Htun Win, Win, HH, McGready, Rose, Nosten, François   +31 more
core   +1 more source

A Systematic Review of Published Physiologically Based Pharmacokinetic Models for Drug Excretion Into Human Breastmilk: Knowledge Gaps and Opportunities to Optimize Reporting and Modeling Practices

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to predict infant exposure to medications via breast milk. Existing guidance on reporting of PBPK modeling analyses is unstructured and nonbinding to researchers. We evaluated reporting practices and modeling approaches in published PBPK modeling studies.
Joshua Kiptoo, Davies Otieno, Kenta Yoshida, Neel Deferm, Aida Nakayiwa Kawuma, Francis Williams Ojara, Adeniyi Olagunju, Jackson K. Mukonzo, Catriona Waitt   +8 more
wiley   +1 more source

Primaquine therapy in PNG.

, 2015
Fitting of the mathematical model to data from PNG. (A) The models fit (solid lines) assuming 100% efficacy of primaquine treatment over the first 60 days after treatment is shown at left.
Miles P. Davenport (68365), Lisa J. White (101780), Christine Luxemburger (315302), Deborah Cromer (282682), Adeshina I. Adekunle (703893), Mykola Pinkevych (125551), François Nosten (17237), Rose McGready (17231)   +7 more
core   +1 more source

Short‐Course Low‐Dose Primaquine for Radical Cure in G6PD‐Normal Patients in the Pre‐Elimination Context of Nepal

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1028-1034, August 2026.
ABSTRACT Background Plasmodium vivax remains a challenge for malaria elimination in Nepal due to its ability to relapse. Radical cure with primaquine is effective but limited by poor adherence to the standard 14‐day low‐dose regimen. In 2022, the WHO recommended administering the same total dose (3.5 mg/kg) over 7 days to improve adherence.
Prakash Ghimire, Gokarna Dahal, Nabaraj Adhikari, Komal Raj Rijal, Sanjib Adhikari, Megha Raj Banjara, Hellen Mnjala, Grant Lee, Sophie Weston, Angela Rumaseb, Anjana Rai, Benedikt Ley, Mohammad Sharif Hossain, Julie A. Simpson, Megha Rajasekhar, Bipin Adhikari, Ric N. Price, Bibek K. Lal, Kamala Thriemer   +18 more
wiley   +1 more source

Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents

Molecules, 2019
This paper describes a continuation of our efforts in the pursuit of novel antiplasmodial agents with optimized properties. Following our previous discovery of biologically potent asymmetric primaquine (PQ) and halogenaniline fumardiamides (1−6 ...
Maja Beus, Diana Fontinha, Jana Held, Zrinka Rajić, Lidija Uzelac, Marijeta Kralj, Miguel Prudêncio, Branka Zorc   +7 more
doaj   +1 more source

Enantiomeric resolution of primaquine, quinacrine and tafenoquine antibacterial medicines using ristocetin macrocyclic glycopeptide antibiotics CSP

Journal of Taibah University for Science, 2020
The enantiomeric resolution of primaquine, quinacrine and tafenoquine antibacterial medicines is described on Chirobiotc R column (150 ×4.6 mm, 5.0 µm). Two eluents used were methanol–acetonitrile-water-triethyl amine in the ratio of 70:10:20:0.1 (I) and
Zeid A. ALOthman, Abdullah G. ALanazi, Imran Ali   +2 more
doaj   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, Volume 13, Issue 40, 17 July 2026.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Operational strategies of anti-malarial drug campaigns for malaria elimination in Zambia's southern province: a simulation study [PDF]

, 2016
BACKGROUND: Malaria elimination requires reducing both the potential of mosquitoes to transmit parasites to humans and humans to transmit parasites to mosquitoes. To achieve this goal in Southern province, Zambia a mass test and treat (MTAT) campaign was
Miller, John M., Erin M. Stuckey, Rick Steketee, Stuckey, Erin M., Chitnis, Nakul, Steketee, Rick, Megan Littrell, Nakul Chitnis, Littrell, Megan, John M. Miller   +9 more
core   +1 more source