Results 51 to 60 of about 16,373 (205)

Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial

Malaria Journal, 2019
Background To reduce onward falciparum malaria transmission, the World Health Organization recommends adding single low-dose (SLD) primaquine to artemisinin-based combination treatment in low transmission areas. However, uptake of this recommendation has
Jaishree Raman, Elizabeth Allen, Lesley Workman, Aaron Mabuza, Hendrik Swanepoel, Gillian Malatje, John Frean, Lubbe Wiesner, Karen I. Barnes   +8 more
doaj   +1 more source

Safety and Efficacy of Adding a Single Low Dose of Primaquine to the Treatment of Adult Patients With Plasmodium falciparum Malaria in Senegal, to Reduce Gametocyte Carriage: A Randomized Controlled Trial. [PDF]

, 2017
Introduction: More information is needed about the safety of low-dose primaquine in populations where G6PD deficiency is common. Methods: Adults with Plasmodium falciparum malaria were randomized to receive 1 of 3 artemisinin combination therapies (ACTs)
Fall, Fatou B, Faye, Babacar, Faye, Babacar T, Gaye, Oumar, Greenwood, Brian, Milligan, Paul, Ndiaye, Jean Louis, Ndiaye, Magatte, Poirot, Eugenie, Sow, Doudou, Sylla, Khadime, Tine, Roger C, Wang, Duolao   +12 more
core   +4 more sources

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Modelling primaquine-induced haemolysis in G6PD deficiency

eLife, 2017
Primaquine is the only drug available to prevent relapse in vivax malaria. The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd).
James Watson, Walter RJ Taylor, Didier Menard, Sim Kheng, Nicholas J White   +4 more
doaj   +1 more source

Safety and efficacy of primaquine in patients with Plasmodium vivax malaria from South Asia: a systematic review and individual patient data meta-analysis

BMJ Global Health, 2023
Background The optimal dosing of primaquine to prevent relapsing Plasmodium vivax malaria in South Asia remains unclear. We investigated the efficacy and safety of different primaquine regimens to prevent P.
Philippe J Guérin, Kavitha Saravu, Julie A Simpson, Bipin Adhikari, Komal Raj Rijal, Prakash Ghimire, Mark Rowland, Sasithon Pukrittayakamee, Amit Sharma, Manju Rahi, Praveen K Bharti, Ric N Price, Megha Rajasekhar, Toby Leslie, Reena Verma, Rishikesh Kumar, Sauman Singh-Phulgenda, Robert J Commons, Apoorv Gupta, Nitika, Kamala Thriemer, Mohammad Shafiul Alam, Wasif A Khan, Benedikt Ley, Alejandro Llanos-Cuentas   +24 more
doaj   +1 more source

Are transnational tobacco companies' market access strategies linked to economic development models? A case study of South Korea. [PDF]

, 2013
Transnational tobacco companies (TTCs) have used varied strategies to access previously closed markets. Using TTCs' efforts to enter the South Korean market from the late 1980s as a case study, this article asks whether there are common patterns in these
Amon, A, Asgari, M, Blake, C, Choi, A, Erben, T, Glazebrook, K, Harnois-Déraps, J, Heymans, C, Hildebrandt, H, Hoekstra, H, Johnson, A, Joudaki, S, Klaes, D, Kuijken, K, Lidman, C, Mead, A, Miller, L, Parkinson, D, Poole, GB, Schneider, P, Viola, M, Wolf, C   +21 more
core   +6 more sources

Crystal structure of Plasmodium vivax macrophage migration inhibitory factor

Acta Crystallographica Section F, EarlyView.
The production, crystallization and 1.8 Å resolution crystal structure of macrophage migratory inhibitory factor from P. vivax are reported.Plasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory ...
Aryana Nair, Matthew Lin, Arav Srivastava, Lijun Liu, Anne Cooper, Kevin Battaile, Elizabeth Harmon, Peter J. Myler, Bart L. Staker, Scott Lovell, Graham Chakafana, Oluwatoyin A. Asojo   +11 more
wiley   +1 more source

Access to primaquine in the last mile: challenges at the service delivery points in pre-elimination era, Myanmar

Tropical Medicine and Health, 2018
Background Alongside monitoring of the disease burden, the successful move towards malaria elimination relies on the readiness of the health care delivery system.
Kay Thwe Han, Khin Thet Wai, Tin Oo, Aung Thi, Zayar Han, Daw Kyin Hla Aye, Aung Ye Naung Win, Jetsumon Prachumsri   +7 more
doaj   +1 more source

Strong Cross‐Reactivity of Anti–Plasmodium falciparum pLDH Monoclonal Antibodies With Plasmodium malariae pLDH in the Abbott Bioline Malaria Ag P.f/P.f/P.v Rapid Diagnostic Test

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objectives This study aimed to describe the cross‐reactivity of the Abbott Bioline Malaria Ag P.f/P.f/P.v rapid diagnostic test, designed to detect Plasmodium falciparum and P. vivax, with other Plasmodium species, based on the detection of parasite lactate dehydrogenase enzymes.
Gabriel Montoia, Maria Carmen Arroyo Sanchez, Giselle Lima‐Cooper, Maria de Lourdes Rego Neves Farinas, Juliana Inoue, Silvia Maria Di Santi   +5 more
wiley   +1 more source

The reality of using primaquine

Malaria Journal, 2010
Background Primaquine is currently the only medication used for radical cure of Plasmodium vivax infection. Unfortunately, its use is not without risk. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency have an increased susceptibility to ...
Bancone Germana, Burgoine Kathy L, Nosten François   +2 more
doaj   +1 more source