Results 31 to 40 of about 3,657 (146)

Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunate. [PDF]

, 2007
BACKGROUND: P. falciparum gametocytes may persist after treatment with sulphadoxine-pyrimethamine (SP) plus artesunate (AS) and contribute considerably to malaria transmission.
Alifrangis, M., Mosha, F., Anders Enevold, Bousema, Teun, Arnold Ndaro, Shekalaghe Seif, Shekalaghe, Seif, van Meegeren Monique, Sauerwein Robert, Sauerwein, R.W., Seif Shekalaghe, Gosling Roly, Shekalaghe, S., Ndaro, A., Frank Mosha, Enevold Anders, Drakeley, Chris, Gosling, R., Chris Drakeley, Monique van Meegeren, Teun Bousema, Meegeren, M. van, Robert Sauerwein, van Meegeren, Monique, Enevold, A., Bousema, T., Sauerwein, R., Mosha, Frank, Alifrangis Michael, Drakeley Chris, Bousema Teun, Ndaro Arnold, Gosling, Roly, Drakeley, C., Enevold, Anders, Michael Alifrangis, Alifrangis, Michael, Sauerwein, Robert, Mosha Frank, Meegeren, M.E.R. van, Roly Gosling, Ndaro, Arnold   +41 more
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Primaquine 30 mg/day versus 15 mg/day during 14 days for the prevention of Plasmodium vivax relapses in adults in French Guiana: a historical comparison

Malaria Journal, 2018
Background The preventive treatment of Plasmodium vivax relapse recommended by the World Health Organization is primaquine at a dose of 15 mg/day for 14 days, except for malaria cases from Asia and Oceania.
Audrey Valdes, Loic Epelboin, Emilie Mosnier, Gaelle Walter, Guillaume Vesin, Philippe Abboud, Alessia Melzani, Denis Blanchet, Nicaise Blaise, Mathieu Nacher, Magalie Demar, Felix Djossou   +11 more
doaj   +1 more source

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections. [PDF]

, 2010
BACKGROUND: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox-Singh, J, Siti Khatijah, Binti Zakaria, Daneshvar, C., Zakaria Siti K, Paul CS Divis, Daneshvar, C, Singh Balbir, Balbir, Singh, Divis Paul CS, Rafa'ee, Mohammad Z., Singh, Balbir, Janet Cox-Singh, Daneshvar, Cyrus, Mohammad Zakri, Rafa’ee, Rafa'ee Mohammad Z, Divis, Paul C. S., Singh, B, Balbir Singh, Daneshvar Cyrus, Cox-Singh Janet, Timothy ME Davis, Siti K Zakaria, Zakaria, SK, Davis, T.M.E, Cyrus CyrusDaneshvar, Paul C, Divis, Cox Singh, Janet, Davis, TM, Davis, Timothy M. E., Rafa'ee, MZ, Davis Timothy ME, Mohammad Z Rafa'ee, Cox-Singh, J., Cyrus Daneshvar, Zakaria, Siti K., Divis, PC   +35 more
core   +1 more source

Quality of antimalarial drugs and antibiotics in Papua New Guinea : a survey of the health facility supply chain [PDF]

, 2014
Poor-quality life-saving medicines are a major public health threat, particularly in settings with a weak regulatory environment. Insufficient amounts of active pharmaceutical ingredients (API) endanger patient safety and may contribute to the ...
Betuela Inoni, Davis, T., Page-Sharp Madhu, Betuela, I., Page-Sharp, Madhu, Bala, Nancy, Bala Nancy, Manuel W Hetzel, Timothy M E Davis, Evelyn K Lavu, Pulford Justin, Lavu, Evelyn K., Nancy Bala, Nancy Bala (563875), Hetzel Manuel W., Davis Timothy M. E., Madhu Page-Sharp (563874), Evelyn K. Lavu (563877), Davis, Timothy M. E., Lavu Evelyn K., Justin Pulford, Lavu, E., Bala, N., Pulford, J., Madhu Page-Sharp, Betuela, Inoni, Inoni Betuela, Hetzel, M., Hetzel, Manuel W., Pulford, Justin, Justin Pulford (563876), Inoni Betuela (67110), Timothy M. E. Davis (112260), Manuel W. Hetzel (563873)   +33 more
core   +2 more sources

Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries. [PDF]

PLoS Neglected Tropical Diseases, 2018
Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure').
Judith Recht, Elizabeth A Ashley, Nicholas J White   +2 more
doaj   +1 more source

A randomized open-label trial of artesunate- sulfadoxine-pyrimethamine with or without primaquine for elimination of sub-microscopic P. falciparum parasitaemia and gametocyte carriage in eastern Sudan. [PDF]

, 2007
BACKGROUND: In areas of seasonal malaria transmission, treatment of asymptomatic carriers of malaria parasites, whose parasitaemia persists at low densities throughout the dry season, could be a useful strategy for malaria control.
El-Sayed, Badria, Ageep, Tellal, Salah-Eldin El-Zaki, Ahmed Babiker, Fathi Mansour, Nahla Gadalla, Tellal Ageep, Paul Milligan, El-Sayed Badria, Babiker Hamza, Baraka Omer, Babiker, Hamza, Milligan Paul, Milligan, Paul, El-Zaki Salah-Eldin, Omer Baraka, Gadalla Nahla, Gadalla, Nahla, Baraka, Omer, Babiker Ahmed, Ageep Tellal, Badria El-Sayed, Babiker, Ahmed, Mansour, Fathi, Mansour Fathi, Hamza Babiker, El-Zaki, Salah-Eldin   +26 more
core   +1 more source

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs. [PDF]

, 2010
BACKGROUND: There is renewed acknowledgement that targeting gametocytes is essential for malaria control and elimination efforts. Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation ...
Bousema, Teun, Shekalaghe, Seif, Ghani, Azra C, Sauerwein Robert, Lucy Okell, Seif Shekalaghe, Shekalaghe, S., Colin Sutherland, Sutherland, Colin, Azra C Ghani, Ghani Azra C, Ghani, AC, Drakeley, Chris, Griffin, JT, Okell Lucy, Drakeley, C, Okell, L., Omar, Sabah, Sutherland Colin, Bousema, T., Sauerwein, R, Griffin, Jamie T, Drakeley Chris, Bousema Teun, Sawa, P., Jamie T Griffin, Shekalaghe, S, Drakeley, C., Omar, S., Okell, L, Sauerwein, Robert, Sawa, P, Shekalaghe Seif, Omar, S, Sauerwein, R.W., Sutherland, C, Ghani, A.C., Sawa, Patrick, Omar Sabah, Teun Bousema, Chris Drakeley, Sabah Omar, Robert Sauerwein, Okell, Lucy, Griffin, J.T., Bousema, T, Sutherland, C., Patrick Sawa, Sawa Patrick, Griffin Jamie T   +49 more
core   +2 more sources

Global perspectives on CYP2D6 associations with primaquine metabolism and Plasmodium vivax radical cure

Frontiers in Pharmacology, 2022
Clinical trial and individual patient treatment outcomes have produced accumulating evidence that effective primaquine (PQ) treatment of Plasmodium vivax and P.
Jasmine M. Olvany, Jasmine M. Olvany, Jasmine M. Olvany, Scott M. Williams, Scott M. Williams, Peter A. Zimmerman, Peter A. Zimmerman   +6 more
doaj   +1 more source

Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia

Malaria Journal, 2019
Background Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited.
Agus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A. Lampah, Kamala Thriemer, Nicholas M. Anstey, Paulus Sugiarto, Julie A. Simpson, Ric N. Price, Nicholas M. Douglas, Jeanne R. Poespoprodjo   +11 more
doaj   +1 more source

Rationale for short course primaquine in Africa to interrupt malaria transmission. [PDF]

, 2012
Following the recent successes of malaria control in sub-Saharan Africa, the gametocytocidal drug primaquine needs evaluation as a tool to further reduce the transmission of Plasmodium falciparum malaria. The drug has scarcely been used in Africa because
Bousema, Teun, Eziefula Alice C, Gosling Roly, Eziefula, A.C., Primaquine in Africa Discussion Group, Drakeley, Chris, Gosling, R., Lorenz von Seidlein, Teun Bousema, Chris Drakeley, Hsiang, Michelle S, Michelle S Hsiang, Hwang Jimee, Hwang, Jimee, Eziefula, Alice C, Bousema, J.T., Jimee Hwang, Hsiang Michelle S, Drakeley Chris, Bousema Teun, von Seidlein, L., Hsiang, M.S., on behalf of the Primaquine in Africa Discussion, G., Gosling, Roly, Drakeley, C., von Seidlein Lorenz, Alice C Eziefula, von Seidlein, Lorenz, Roly Gosling, Hwang, J.   +29 more
core   +2 more sources