Results 11 to 20 of about 3,657 (146)

An increase in urinary primaquine and a reduction in urinary primaquine-5,6-orthoquinone in the Thai population with CYP2D6 reduced enzyme function

Heliyon
Objectives: Primaquine is metabolized by the cytochrome P450-2D6 enzyme (CYP2D6) to an active primaquine-5,6-orthoquinone (POQ). No relationships of CYP2D6 polymorphisms with the pharmacokinetics of primaquine and POQ were reported in the Thai population.
Supeecha Wittayalertpanya, Mathirut Mungthin, Chonlaphat Sukasem   +2 more
exaly   +4 more sources

Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes [PDF]

Malaria Journal, 2019
Background The activity and haemolytic toxicity associated with primaquine has been linked to its reactive metabolites. The reactive metabolites are thought to be primarily formed through the action of cytochrome P450-mediated pathways.
Pius S. Fasinu, N. P. Dhammika Nanayakkara, Yan-Hong Wang, Narayan D. Chaurasiya, H. M. Bandara Herath, James D. McChesney, Bharathi Avula, Ikhlas Khan, Babu L. Tekwani, Larry A. Walker   +9 more
doaj   +2 more sources

The reality of using primaquine [PDF]

Malaria Journal, 2010
Background Primaquine is currently the only medication used for radical cure of Plasmodium vivax infection. Unfortunately, its use is not without risk. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency have an increased susceptibility to ...
Bancone Germana, Burgoine Kathy L, Nosten François   +2 more
doaj   +3 more sources

Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study

Molecules, 2021
The method for the determination of primaquine (PQ) and 5,6-orthoquinone primaquine (5,6-PQ), the representative marker for PQ active metabolites, via CYP2D6 in human plasma and urine has been validated.
Supeecha Wittayalertpanya, Mathirut Mungthin, Chonlaphat Sukasem   +2 more
exaly   +3 more sources

Modelling primaquine-induced haemolysis in G6PD deficiency [PDF]

eLife, 2017
Primaquine is the only drug available to prevent relapse in vivax malaria. The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd).
James Watson, Walter RJ Taylor, Didier Menard, Sim Kheng, Nicholas J White   +4 more
doaj   +2 more sources

Primaquine Therapy for Malaria [PDF]

Clinical Infectious Diseases, 2004
Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its use. This review examines the wide range of clinical applications of primaquine described in the medical literature between 1946 and 2004. The risk of relapse of Plasmodium vivax malaria without primaquine therapy ranged from 5% to 80% or more ...
Baird, J. Kevin, Hoffman, Stephen L.
openaire   +5 more sources

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth

Redox Biology, 2016
Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax.
Cindy Vallières, Jérôme Clain, Simon Avery   +2 more
exaly   +3 more sources

Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: A hospital-based cohort study

PLoS Medicine, 2017
BackgroundPrimaquine is the only licensed drug for eradicating Plasmodium vivax hypnozoites and, therefore, preventing relapses of vivax malaria. It is a vital component of global malaria elimination efforts.
Michael Malloy, Nicholas Anstey, Julie Simpson   +2 more
exaly   +2 more sources

Mechanistic Modeling of Primaquine Pharmacokinetics, Gametocytocidal Activity, and Mosquito Infectivity [PDF]

, 2022
Clinical studies have shown that adding a single 0.25 mg base/kg dose of primaquine to standard antimalarial regimens rapidly sterilizes Plasmodium falciparum gametocytes.
Julie A. Simpson, Bousema, Teun, White, Nicholas J., Koita, Fanta, Mahamar, Almahamoudou, Richard M. Hoglund, Alassane Dicko, Halimatou Diawara, Brown, Joelle M., White, Nicholas J, Teun Bousema, Dicko, Alassane, Simpson, Julie A., Tarning, Joel, Hoglund, Richard M, Simpson, Julie A, Hoglund, Richard M., Sanogo, Koualy, Chotsiri, Palang, Ingrid Chen, Joel Tarning, Fanta Koita, Diawara, Halimatou, Almahamoudou Mahamar, Brown, Joelle M, Palang Chotsiri, Nicholas J. White, Gosling, Roly, Joelle M. Brown, Koualy Sanogo, Roly Gosling, Chen, Ingrid   +31 more
core   +4 more sources

Genetic Variation of G6PD and CYP2D6: Clinical Implications on the Use of Primaquine for Elimination of Plasmodium vivax

Frontiers in Pharmacology, 2021
Primaquine, an 8-aminoquinoline, is the only medication approved by the World Health Organization to treat the hypnozoite stage of Plasmodium vivax and P. ovale malaria.
Alexandra G. A. Stewart, Peter A. Zimmerman, James S. McCarthy, James S. McCarthy   +3 more
doaj   +1 more source