Results 81 to 90 of about 16,373 (205)

Factors affecting primaquine combination treatment in Malaria patients in Selangor, Malaysia

Journal of Pharmacy and Bioallied Sciences, 2017
Introduction: Primaquine is vital for the management of liver-stage Plasmodium vivax and Plasmodium ovale malaria. However, primaquine effectiveness is dependent on various factors and differs between populations.
Norliza Mat Ariffin, Farida Islahudin, Mohd Makmor-Bakry, Endang Kumolosasi, Mohd Hafizi A Hamid   +4 more
doaj   +1 more source

Primaquine Therapy for Malaria [PDF]

Clinical Infectious Diseases, 2004
Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its use. This review examines the wide range of clinical applications of primaquine described in the medical literature between 1946 and 2004. The risk of relapse of Plasmodium vivax malaria without primaquine therapy ranged from 5% to 80% or more ...
Baird, J. Kevin, Hoffman, Stephen L.
openaire   +2 more sources

Antimalarial Polyethylene Glycol–Lumefantrine Conjugates: Synthesis and Effect of Linker Chemistry on Drug Release

Advanced Therapeutics, Volume 9, Issue 2, February 2026.
Research into advanced therapeutics for malaria are rare. We investigate how linker chemistry governs the release kinetics of the antimalarial lumefantrine from polyethylene glycol conjugates. A clear correlation between diacid linker length and drug release rate is established, enabling rational design of conjugates with controlled release.
Thenesia R. Govender, William M. R. Matshe, Nokuthula Dube, Zamani E. D. Cele, Aurelia A. Williams, Lynne A. Pilcher, Mohammed O. Balogun   +6 more
wiley   +1 more source

Estudio piloto de la eficacia y de los efectos sobre los gametocitos del esquema artesunato-mefloquina-primaquina para la malaria por Plasmodium falciparum

Biomédica: revista del Instituto Nacional de Salud, 2009
Introducción. El tratamiento de la malaria por P. falciparum requiere de un esquema seguro, eficaz y de impacto en la transmisión. En 2006, se implementó en Antioquia el esquema artesunato-mefloquina y se adicionó primaquina para eliminar los gametocitos.
Ana María Vásquez, Felipe Sanín, Luis Gonzalo Álvarez, Alberto Tobón, Alexandra Ríos, Silvia Blair   +5 more
doaj   +1 more source

Analysis of Global Research on Malaria and Plasmodium vivax [PDF]

, 2019
Background: Malaria is one of the infectious diseases of greatest interest to the scientific community and of greatest concern to international health authorities.
Cebrián Carmona, José, Garrido Cárdenas, José Antonio, González Cerón, Lilia, Manzano Agugliaro, Francisco, Mesa Valle, Concepción   +4 more
core   +1 more source

Subdoses de primaquina associadas a recaídas de malária vivax em pacientes com peso elevado : relato de dois casos no Distrito Federal [PDF]

, 2010
São apresentados dois casos de pacientes com malária por Plasmodium vivax que apresentaram recaídas após tratamento com medicamentos em doses indicadas pelo Ministério da Saúde.
Deckers, Fernando Augusto Lopes, Luz, Francisco das Chagas de Oliveira, Santos, João Barberino, Tauil, Pedro Luiz   +3 more
core   +2 more sources

Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 589-605, February 2026.
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding, Richard M. Hoglund, Rob W. van der Pluijm, James J. Callery, Thomas J. Peto, Rupam Tripura, Sukanta Das, Nguyễn Hoàng Châu, Cholrawee Promnarate, Mavuto Mukaka, Lek Dysoley, Caterina Fanello, Marie A. Onyamboko, Anupkumar R. Anvikar, Mayfong Mayxay, Frank Smithuis, Lorenz von Seidlein, Mehul Dhorda, Chanaki Amaratunga, M. Abul Faiz, Ho Dang Trung Nghia, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp, Joel Tarning   +24 more
wiley   +1 more source

Ultrastructural alterations in Schistosoma mansoni juvenile and adult male worms after in vitro incubation with primaquine

Memorias do Instituto Oswaldo Cruz
BACKGROUND Praziquantel has been cited as the only drug for treating schistosomiasis. However, concerns over drug resistance have encouraged the search for novel drug leads.
Reem Osama A Kamel, Fatma El-Zahraa Anwar Bayaumy   +1 more
doaj   +1 more source

Methemoglobinemia in patients with Plasmodium vivax receiving oral therapy with primaquine [PDF]

, 2011
Primaquine can produce adverse reactions as toxicity to blood when used in the treatment of vivax malaria. This work aimed to determine methemoglobinemia in patients with vivax malaria receiving oral therapy with primaquine.
FERREIRA, Michelli Erica Souza, GOMES, Margarete do Socorro Mendonça, VIEIRA, José Luiz Fernandes   +2 more
core   +1 more source

A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance. [PDF]

, 2017
Background: Single low-dose primaquine (PQ) reduces Plasmodium falciparum infectivity before it impacts gametocyte density. Here, we examined the effect of PQ on gametocyte sex ratio as a possible explanation for this early sterilizing effect.
Alano, Pietro, Bousema, Teun, Bradley, John, Brown, Joelle, Chen, Ingrid, Diawara, Halimatou, Dicko, Alassane, Drakeley, Chris, Gosling, Roly, Graumans, Wouter, Lanke, Kjerstin, Mahamar, Almahamoudou, Nyaurah, Maureen, Oriango, Robin, Osodo, Paul, Osoti, Victor, Rijpma, Sanna, Sawa, Patrick, Siciliano, Giulia, Stone, Will, van de Vegte-Bolmer, Marga, Woestenenk, Rob   +21 more
core   +2 more sources