Results 11 to 20 of about 342,683 (247)

Extending seasonal malaria chemoprevention to five cycles: a pilot study of feasibility and acceptability in Mangodara district, Burkina Faso

BMC Public Health, 2022
Background Seasonal malaria chemoprevention (SMC) involves administering antimalarial drugs at monthly intervals during the high malaria transmission period to children aged 3 to 59 months as recommended by the World Health Organization.
Adama Traore, Laura Donovan, Benoit Sawadogo, Charlotte Ward, Helen Smith, Christian Rassi, Helen Counihan, Johanna Johansson, Sol Richardson, Justin Ragnessi Savadogo, Kevin Baker   +10 more
doaj   +1 more source

Rational use of antibiotics by community health workers and caregivers for children with suspected pneumonia in Zambia: a cross-sectional mixed methods study

BMC Public Health, 2016
Background Antibiotic resistance is an issue of growing global concern. One key strategy to minimise further development of resistance is the rational use of antibiotics, by providers and patients alike. Through integrated community case management (iCCM)
Kirstie Graham, Chomba Sinyangwe, Sarala Nicholas, Rebecca King, Samuel Mukupa, Karin Källander, Helen Counihan, Mark Montague, James Tibenderana, Prudence Hamade   +9 more
doaj   +1 more source

A feasibility study to assess non-clinical community health workers’ capacity to use simplified protocols and tools to treat severe acute malnutrition in Niger state Nigeria

BMC Health Services Research, 2021
Background Severe acute malnutrition (SAM) is a major determinant of childhood mortality and morbidity. Although integrated community case management (iCCM) of childhood illnesses is a strategy for increasing access to life-saving treatment, malnutrition
Olatunde Adesoro, Olusola Oresanya, Helen Counihan, Prudence Hamade, Dare Eguavon, Chika Emebo, Bethany Marron, Naoko Kozuki, Amina Isah, Patrick Gimba, Chris Osa Isokpunwu, Kolawole Maxwell, James K. Tibenderana   +12 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Adherence to referral advice and its associated factors among community drug distributors and caregiver during SMC implementation in nine states

Malaria Journal
Background Malaria is a global public health problem that disproportionately affects under-five children in poor resource countries. Nigeria accounted for the highest burden of malaria in Western Africa.
Taiwo Ibinaiye, Ayodeji Balogun, Emmanuel Salifu, Benjamin Amao, Emmanuel Musa, Daniel Emeto, Samuel Ayoola, Usman Hussaini, Chibuzo Oguoma, Abdullahi Abdulrazak, Zechariah Maleeks, Olabisi Ogunmola, Olusola Oresanya, Kunle Rotimi   +13 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Urban–rural differences in seasonal malaria chemoprevention coverage and characteristics of target populations in nine states of Nigeria: a comparative cross-sectional study

Malaria Journal
Background Differences between urban and rural contexts in terms of sociodemographic characteristics, geographical features and risk perceptions may lead to disparities in coverage and related outcomes of community-based preventive interventions, such as
Taiwo Ibinaiye, Kunle Rotimi, Ayodeji Balogun, Adaeze Aidenagbon, Chibuzo Oguoma, Kevin Baker, Olabisi Ogunmola, Olusola Oresanya, Christian Rassi, Chuks Nnaji   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Delivering insecticide-treated nets (ITNs) through a digitized single-phase door-to-door strategy: lessons from Ondo state, Nigeria

Malaria Journal
Background The use of insecticide-treated nets (ITNs) is a strategy recommended by the World Health Organization (WHO) for malaria prevention. In Nigeria, ITNs have been periodically distributed since 2007 through campaigns.
Laitan Adeniyi, Elisabeth G. Chestnutt, Kunle Rotimi, Azuka Iwegbu, Olusola Oresanya, Julianna Smith, Kolawole Maxwell, Tarekegn A. Abeku   +7 more
doaj   +1 more source

The acceptability of mass administrations of anti-malarial drugs as part of targeted malaria elimination in villages along the Thai–Myanmar border

Malaria Journal, 2016
Background A targeted malaria elimination project, including mass drug administrations (MDA) of dihydroartemisinin/piperaquine plus a single low dose primaquine is underway in villages along the Thailand Myanmar border.
Ladda Kajeechiwa, May Myo Thwin, Paw Wah Shee, Nan Lin Yee, Elvina Elvina, Peapah Peapah, Kyawt Kyawt, Poe Thit Oo, William PoWah, Jacqueline Roger Min, Jacher Wiladphaingern, Lorenz von Seidlein, Suphak Nosten, Francois Nosten   +13 more
doaj   +1 more source