Results 61 to 70 of about 532,559 (334)

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Comparison of three diagnostic methods (microscopy, RDT, and PCR) for the detection of malaria parasites in representative samples from Equatorial Guinea

Malaria Journal, 2018
Malaria in Equatorial Guinea remains a major public health problem. The country is a holo-endemic area with a year-round transmission pattern. In 2016, the prevalence of malaria was 12.09% and malaria caused 15% of deaths among children under 5 years. In
P. Berzosa, A. de Lucio, M. Romay-Barja, Z. Herrador, V. González, L. García, A. Fernández-Martínez, M. Santana-Morales, P. Ncogo, B. Valladares, M. Riloha, A. Benito   +11 more
semanticscholar   +1 more source

Sub-national stratification of malaria risk in mainland Tanzania: a simplified assembly of survey and routine data

Malaria Journal, 2020
Recent malaria control efforts in mainland Tanzania have led to progressive changes in the prevalence of malaria infection in children, from 18.1% (2008) to 7.3% (2017).
Sumaiyya G. Thawer, Frank Chacky, Manuela Runge, E. Reaves, R. Mandike, S. Lazaro, S. Mkude, S. Rumisha, Claud Kumalija, C. Lengeler, A. Mohamed, E. Pothin, R. Snow, F. Molteni   +13 more
semanticscholar   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, EarlyView.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

Shifting transmission risk for malaria in Africa with climate change: a framework for planning and intervention

Malaria Journal, 2019
Malaria continues to be a disease of massive burden in Africa, and the public health resources targeted at surveillance, prevention, control, and intervention comprise large outlays of expense.
S. Ryan, C. Lippi, F. Zermoglio
semanticscholar   +1 more source

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

Advanced Science, EarlyView.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification. .
Linlin Cheng, Mansheng Li, Zhou Bai, Xiaobo Yu, Wenjie Zheng, Yongzhe Li, Yudong Liu   +6 more
wiley   +1 more source

Awareness, knowledge, attitude, and practice of adverse drug reaction reporting among health workers in primary health centres participating in seasonal malaria chemoprevention campaign in Nigeria in 2022: a cross-sectional survey

BMC Health Services Research
Background Evaluating health workers’ knowledge and practice of adverse drug reaction (ADR) reporting is an important step in identifying gaps in quality ADR reporting during public health interventions like the seasonal malaria chemoprevention (SMC ...
Kunle Rotimi, Babatunde Fagbemi, Grace Omole, Aminu Ahmed Biambo, Taiwo Ibinaiye, Azuka Iwegbu, Olabisi Ogunmola, Chibuzo Oguoma, Olusola Oresanya   +8 more
doaj   +1 more source

Insecticide resistance patterns in Uganda and the effect of indoor residual spraying with bendiocarb on kdr L1014S frequencies in Anopheles gambiae s.s.

Malaria Journal, 2017
Background Resistance of malaria vectors to pyrethroid insecticides has been attributed to selection pressure from long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and the use of chemicals in agriculture.
Tarekegn A. Abeku, Michelle E. H. Helinski, Matthew J. Kirby, James Ssekitooleko, Chris Bass, Irene Kyomuhangi, Michael Okia, Godfrey Magumba, Sylvia R. Meek   +8 more
doaj   +1 more source

Delivery of seasonal malaria chemoprevention with enhanced infection prevention and control measures during the COVID-19 pandemic in Nigeria, Burkina Faso and Chad: a cross-sectional study

Malaria Journal, 2022
Background Seasonal malaria chemoprevention (SMC) is a WHO-recommended intervention for children aged 3–59 months living in areas of high malaria transmission to provide protection against malaria during the rainy season.
Charlotte Ward, Abimbola Phillips, Olusola Oresanya, Gloria Olisenekwu, Ekundayo Arogunade, Azoukalné Moukénet, Honoré Beakgoubé, Vincent De Paul Allambademel, Cheick Saïd Compaoré, Adama Traoré, Jean-Bosco Ouedraogo, Yves Daniel Compaoré, Issaka Zongo, Laura Donovan, Monica Anna Decola, Helen Smith, Kevin Baker   +16 more
doaj   +1 more source

Electronic Nanomaterials for Plants: A Review on Current Advances and Future Prospects

Advanced Electronic Materials, EarlyView.
Global food security faces mounting challenges from climate change and rapid population growth. This review highlights the pivotal role of electronic nanomaterials–including metals, metal oxides, and carbon‐based structures–in enhancing plant photosynthesis, nutrient uptake, and stress resilience. Furthermore, it explores how emerging platforms such as
Ciro Allará, Giuseppe Ciccone, Manuela Ciocca, Sahira Vasquez, Pietro Ibba, Mauro Maver, Tanja Mimmo, Paolo Lugli, Luisa Petti   +8 more
wiley   +1 more source