Results 51 to 60 of about 361,983 (304)

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

A quasi-experimental study to estimate effectiveness of seasonal malaria chemoprevention in Aweil South County in Northern Bahr El Ghazal, South Sudan

Malaria Journal
Background Seasonal malaria chemoprevention (SMC) is an effective intervention to prevent malaria in children in locations where the burden of malaria is high and transmission is seasonal.
Jamshed Khan, Maria Suau Sans, Francis Okot, Abubaker Rom Ayuiel, Jonathan Magoola, Christian Rassi, Sikai Huang, Denis Mubiru, Craig Bonnington, Kevin Baker, Julla Ahmed, Chuks Nnaji, Sol Richardson   +12 more
doaj   +1 more source

Pearl's causality for integrating ecological datasets: A case study on Myricaria germanica in northern Italy

Applications in Plant Sciences, EarlyView.
Abstract Premise Applied ecology can significantly influence policy decisions on environmental issues. Therefore, research in this field should be as transparent and reproducible as possible. Existing expertise from a broad range of disciplines should also be integrated into ecological research to allow researchers to maximize understanding of complex ...
Kailin Weitkämper, Kilian Rückschloß, Tommaso Sitzia, Bruno Michielon, Silke Werth, Felix Weitkämper   +5 more
wiley   +1 more source

One-arm safety intervention study on community case management of chest indrawing pneumonia in children in Nigeria – a study protocol

Global Health Action, 2020
Current recommendations within integrated community case management (iCCM) programmes advise community health workers (CHWs) to refer cases of chest indrawing pneumonia to health facilities for treatment, but many children die due to delays or non ...
Helen Counihan, Ebenezer Baba, Olusola Oresanya, Olatunde Adesoro, Yahya Hamzat, Sarah Marks, Charlotte Ward, Patrick Gimba, Shamim Ahmad Qazi, Karin Källander   +9 more
doaj   +1 more source

The Economic Costs of Malaria in Children in three Sub-Saharan Countries: Ghana, Tanzania and Kenya. [PDF]

, 2013
Malaria causes significant mortality and morbidity in sub-Saharan Africa (SSA), especially among children less than five years of age (U5 children).
Sicuri, E, Constenla, Dagna, Dagna Constenla, Elisa Sicuri, Sicuri, Elisa, Vieta, Ana, Constenla, D, Christophe Sauboin, Lindner, Leandro, Vieta, A, Ana Vieta, Lindner, L, Sauboin, C, Sauboin, Christophe, Leandro Lindner   +14 more
core   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Malaria Surveillance \u2014 United States, 2014 [PDF]

Problem/Condition: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles mosquito.

core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Health worker and policy-maker perspectives on use of intramuscular artesunate for pre-referral and definitive treatment of severe malaria at health posts in Ethiopia

Malaria Journal, 2016
Background The World Health Organization (WHO) recommends injectable artesunate given either intravenously or by the intramuscular route for definitive treatment for severe malaria and recommends a single intramuscular dose of intramuscular artesunate or
Takele Kefyalew, Zelalem Kebede, Dawit Getachew, David Mukanga, Tessema Awano, Agonafer Tekalegne, Esey Batisso, Wasihun Edossa, Emebet Mekonnen, James Tibenderana, Ebenezer Sheshi Baba, Constance Shumba, Joaniter I. Nankabirwa, Prudence Hamade   +13 more
doaj   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S   +20 more
core   +1 more source