Results 61 to 70 of about 697,481 (397)

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Malaria [PDF]

Nature Reviews Disease Primers, 2017
(Uploaded by Plazi for the Bat Literature Project) Malaria is caused in humans by five species of single-celled eukaryotic Plasmodium parasites (mainly Plasmodium falciparum and Plasmodium vivax) that are transmitted by the bite of Anopheles spp. mosquitoes.
Margaret A, Phillips, Jeremy N, Burrows, Christine, Manyando, Rob Hooft, van Huijsduijnen, Wesley C, Van Voorhis, Timothy N C, Wells   +5 more
openaire   +3 more sources

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Delivering an insecticide-treated net campaign in a complex operating environment: lessons from Anambra state, Nigeria

Malaria Journal
Background Malaria is one of the leading causes of morbidity and mortality in Nigeria. Distribution of insecticide-treated nets (ITNs) is an important vector control strategy.
Laitan Adeniyi, Kunle Rotimi, Elisabeth G. Chestnutt, Abiola O. Oluwagbemiga, Saliu Ogunmola, Nonso Ndibe, Olusola Oresanya, Julianna Smith, Kolawole Maxwell, Tarekegn A. Abeku   +9 more
doaj   +1 more source

Multi-country review of ITN routine distribution data: are ANC and EPI channels achieving their potential?

Malaria Journal, 2022
Background Routine continuous distribution (CD) of insecticide-treated nets (ITNs) has been an important part of an overall ITN strategy to complement mass campaigns since the early 2000s.
Jane E. Miller, Kezia Malm, Aimain Alexis Serge, Marcellin Joel Ateba, Peter Gitanya, Doudou Sene, Emmanuel H. Kooma, Balla Kandeh, Lilia Gerberg, Luigi Nuñez   +9 more
doaj   +1 more source

Rapid Urban Malaria Appraisal (RUMA) II: epidemiology of urban malaria in Dar es Salaam (Tanzania). [PDF]

, 2006
BACKGROUND\ud \ud The thinking behind malaria research and control strategies stems largely from experience gained in rural areas and needs to be adapted to the urban environment.\ud \ud METHODS\ud \ud A rapid assessment of urban malaria was conducted in
Godson Maro, Wang Shr-Jie, Marcel Tanner, S., Lusinge Manane, Manane, Lusinge, Christian Lengeler, Shr-Jie Wang, Mtasiwa, Deodatus, Deodatus Mtasiwa, Penelope Vounatsou, Marcel Tanner, Lengeler Christian, Vounatsou Penelope, Guéladio Cissé, Maro, G., Wang, S.-J., Lengeler, C., Tanner, Marcel, Lengeler, Christian, Mtasiwa, D., Cissé Guéladio, Mshana, Thomas, Mshana Thomas, Mshana, T., Tanner Marcel, Manane, L., Mtasiwa Deodatus, Maro Godson, Thomas Mshana, Smith Thomas A, Wang, Shr-Jie, Manane Lusinge, Thomas A Smith, Maro, Godson   +33 more
core   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

A quasi-experimental study to estimate effectiveness of seasonal malaria chemoprevention in Aweil South County in Northern Bahr El Ghazal, South Sudan

Malaria Journal
Background Seasonal malaria chemoprevention (SMC) is an effective intervention to prevent malaria in children in locations where the burden of malaria is high and transmission is seasonal.
Jamshed Khan, Maria Suau Sans, Francis Okot, Abubaker Rom Ayuiel, Jonathan Magoola, Christian Rassi, Sikai Huang, Denis Mubiru, Craig Bonnington, Kevin Baker, Julla Ahmed, Chuks Nnaji, Sol Richardson   +12 more
doaj   +1 more source

The Economic Costs of Malaria in Children in three Sub-Saharan Countries: Ghana, Tanzania and Kenya. [PDF]

, 2013
Malaria causes significant mortality and morbidity in sub-Saharan Africa (SSA), especially among children less than five years of age (U5 children).
Sicuri, E, Constenla, Dagna, Dagna Constenla, Elisa Sicuri, Sicuri, Elisa, Vieta, Ana, Constenla, D, Christophe Sauboin, Lindner, Leandro, Vieta, A, Ana Vieta, Lindner, L, Sauboin, C, Sauboin, Christophe, Leandro Lindner   +14 more
core   +1 more source

Amazon deforestation drives malaria transmission, and malaria burden reduces forest clearing

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Widespread human impacts on the environment are expected to harm human health, which may in turn alter our interactions with the environment.
Andrew J. MacDonald, E. Mordecai
semanticscholar   +1 more source