Results 61 to 70 of about 510,136 (295)

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination. [PDF]

, 2015
BACKGROUND: Outside of Africa, P. falciparum and P. vivax usually coexist. In such co-endemic regions, successful malaria control programs have a greater impact on reducing falciparum malaria, resulting in P.
Rita Kusriastuti (164501), Neil Lobo, Ayleen Kosasih, Inge Sutanto (391795), Ferdinand Laihad, Leily Trianty (106253), Kusriastuti, Rita, Andreas Kusuma, Leily Trianty, Noviyanti, Rintis, Farah Coutrier, Taane G Clark, Lobo, Neil, Neil Lobo (736132), Trimarsanto, Hidayat, Clark, Taane G., Taane G. Clark (106263), Inge Sutanto, Rintis Noviyanti, Jutta Marfurt (92157), Marfurt, Jutta, Hawley, William A., Sutanto, Inge, Andreas Kusuma (736130), Ric N. Price (35538), Clark, Taane G, Price, Richard, Ayleen Kosasih (736131), Trianty, Leily, Ferdinand Laihad (80374), Kusuma, Andreas, Rita Kusriastuti, Tirta, Yusrifar K, Utami, Retno A.S., Auburn, Sarah, Jutta Marfurt, Coutrier, Farah, Hawley, William A, Rintis Noviyanti (106250), Sarah Auburn, Hidayat Trimarsanto (443615), Yusrifar K Tirta, Retno A. S. Utami (736128), Hidayat Trimarsanto, Farah Coutrier (736127), William A Hawley, Utami, Retno AS, Kosasih, Ayleen, William A. Hawley (339596), Retno A S Utami, Sarah Auburn (106239), Tirta, Yusrifar K., Laihad, Ferdinand, Yusrifar K. Tirta (736129), Price, Ric N, Ric N Price   +55 more
core   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Ecology: A Prerequisite for Malaria Elimination and Eradication [PDF]

PLoS Medicine, 2010
Gerry Killeen and colleagues argue that malaria eradication efforts will not be successful until a better understanding of the ecology and evolution of the mosquito vectors is gained.
Ferguson, H.M., Dornhaus, A., Beeche, A., Borgemeister, C., Gottlieb, M., Mulla, M.S., Gimnig, J.E., Fish, D., Killeen, G.F.   +8 more
openaire   +4 more sources

Application of mathematical modeling for malaria control decision-making in settings of varying transmission intensity [PDF]

, 2015
Planning for the control of Plasmodium falciparum malaria at the population level demands models of malaria epidemiology that provide realistic quantitative prediction of likely epidemiological outcomes of a wide range of control strategies. This project
Stuckey, Erin Mae
core   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

En-route to the ‘elimination’ of genotypic chloroquine resistance in Western and Southern Zambia, 14 years after chloroquine withdrawal

Malaria Journal, 2019
Background Anti-malarial resistance is, and continues to be a significant challenge in the fight against malaria and a threat to achieving malaria elimination.
Lungowe Sitali, Mulenga C. Mwenda, John M. Miller, Daniel J. Bridges, Moonga B. Hawela, Elizabeth Chizema-Kawesha, James Chipeta, Bernt Lindtjørn   +7 more
doaj   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

High Effective Coverage of Vector Control Interventions in Children After Achieving Low Malaria Transmission in Zanzibar, Tanzania. [PDF]

, 2013
\ud \ud Formerly a high malaria transmission area, Zanzibar is now targeting malaria elimination. A major challenge is to avoid resurgence of malaria, the success of which includes maintaining high effective coverage of vector control interventions such ...
Msellem, Mwinyi, Kristina Elfving, Mwinyi Msellem, Ali, Abdullah S, Elfving, Kristina, Msellem Mwinyi, Al-Mafazy, Abdul-Wahiyd H, Abdullah S Ali, Björkman, Anders, Delér Shakely, Petzold, Max, Petzold Max, Al-Mafazy Abdul-Wahiyd H, Netta Beer, Karin Källander, Shakely, Delér, Källander, Karin, Anders Björkman, Källander Karin, Abdul-Wahiyd H Al-Mafazy, Max Petzold, Ali Abdullah S, Elfving Kristina, Björkman Anders, Beer, Netta, Beer Netta, Shakely Delér   +26 more
core   +1 more source

Purification of Disassembled Capsid Protein by Hydroxyapatite Chromatography Enhances Virus‐Like Particle Recovery

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Virus‐like particles (VLPs) are a promising modality with extensive applications in prophylactic and therapeutic vaccine design. Human Papillomavirus (HPV) vaccines are one such example where VLP vaccine applications have led to the successful reduction in HPV‐associated diseases, such as cervical cancer.
Nicholas Samuelson, Nathaniel Parker, Shiyi Wang, Sara Daley, Aaron Cote, Michael A. Winters   +5 more
wiley   +1 more source