Results 91 to 100 of about 106,967 (273)
Neutropenia as an adverse event following vaccination : results from randomized clinical trials in healthy adults and systematic review [PDF]
Background : In the context of early vaccine trials aimed at evaluating the safety profile of novel vaccines, abnormal haematological values, such as neutropenia, are often reported.
Aerssens, Annelies +10 more
core +4 more sources
CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang +2 more
wiley +1 more source
The repetitive interspersed family (RIFIN) and the subtelomeric variable open reading frame (STEVOR) family represent two of three major Plasmodium falciparum variant surface antigen families involved in malaria pathogenesis and immune evasion and are ...
Albert E. Zhou +26 more
doaj +1 more source
A sequence of computational methods was used for predicting novel drug targets against drug resistant malaria parasite Plasmodium falciparum. Comparative genomics, orthologous protein analysis among same and other malaria parasites and protein-protein ...
Altschul +45 more
core +1 more source
Modeling the public health impact of malaria vaccines for developers and policymakers [PDF]
Efforts to develop malaria vaccines show promise. Mathematical model-based estimates of the potential demand, public health impact, and cost and financing requirements can be used to inform investment and adoption decisions by vaccine developers and ...
Brooks, Alan +7 more
core +1 more source
Benzoxaboroles Are Inhibitors of the η‐Class Carbonic Anhydrase From Plasmodium falciparum
Benzoxaborole‐based inhibitors demonstrate potent, low‐micromolar inhibition of the essential malaria target PfaCA and are effective in vitro suppression of P. falciparum. Molecular docking confirms target engagement via zinc coordination, establishing this chemotype as a promising scaffold for the development of next‐generation antimalarials ...
Alessandro Bonardi +9 more
wiley +1 more source
Factors affecting home delivery in rural Tanzania [PDF]
BACKGROUND\ud \ud Studies of factors affecting place of delivery have rarely considered the influence of gender roles and relations within the household.
Mrisho, M +6 more
core +2 more sources
ABSTRACT In endemic areas, acute undifferentiated febrile illness has a wide differential with overlapping features that can lead to misdiagnosis. Although triple co‐infection with scrub typhus, dengue, and leptospirosis is extremely rare, high clinical suspicion and early detection are vital to avoid delayed treatment, multi‐organ dysfunction, and ...
Sulav Kumar Jha +5 more
wiley +1 more source
Vaccination in emergencies. [PDF]
Nongovernmental organisations (NGOs) are the main actors of vaccine delivery during complex humanitarian emergencies such as large population displacements.
Paquet, C
core +2 more sources
ABSTRACT Background and Aims Necrotizing periodontal diseases (NPDs) represent a significant yet neglected burden in sub‐Saharan Africa, often exacerbated by poverty, malnutrition, HIV, and limited access to oral healthcare. Despite their public health relevance, financing mechanisms supporting their prevention and control in African settings are ...
Kafayat Aminu +9 more
wiley +1 more source

