Results 21 to 30 of about 106,967 (273)

Comparison of ELISA with electro-chemiluminescence technology for the qualitative and quantitative assessment of serological responses to vaccination

Malaria Journal, 2020
Background Profiling immune responses induced by either infection or vaccination can provide insight into identification of correlates of protection.
Jessica S. Bolton, Sidhartha Chaudhury, Sheetij Dutta, Scott Gregory, Emily Locke, Tony Pierson, Elke S. Bergmann-Leitner   +6 more
doaj   +1 more source

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach, Brian Greenwood, Daniel Ansong, David Schellenberg, Jahit Sacarlal, Jennifer Evans, Johan Vekemans, Kevin Marsh, Kwaku Asante, Mary J Hamel, Nahya Salim, null null, Patricia Njuguna, Philip Bejon, Portia Kamthunzi, Samwel Gesase, Solange Soulanoudjingar, Walter Otieno, William Kabore   +18 more
core   +4 more sources

Malaria vaccine development [PDF]

Clinical Microbiology Reviews, 1994
The malaria parasite life cycle presents several targets for attack, but these different parts of the life cycle are susceptible to different types of host immune response. For example, the sporozoite is most sensitive to immune antibody, while liver stage parasites can be eliminated by cytotoxic T lymphocytes. Attachment of merozoites to erythrocytes,
T R, Jones, S L, Hoffman
openaire   +2 more sources

Process development and preclinical evaluation of a major Plasmodium falciparum blood stage vaccine candidate, Cysteine-Rich Protective Antigen (CyRPA)

Frontiers in Immunology, 2022
Plasmodium falciparum Cysteine-Rich Protective Antigen (CyRPA) is an essential, highly conserved merozoite antigen that forms an important multi-protein complex (RH5/Ripr/CyRPA) necessary for erythrocyte invasion. CyRPA is a promising blood-stage vaccine
Anjali Somanathan, Syed Yusuf Mian, Kritika Chaddha, Seemalata Uchoi, Praveen K. Bharti, Ravi Tandon, Deepak Gaur, Virander Singh Chauhan   +7 more
doaj   +1 more source

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines [PDF]

, 2014
BackgroundPolymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development.
Anders, Robin F., Barry, Alyssa E., Beeson, James G., Cross, Nadia J., Drew, Damien R., Dutta, Sheetij, Elliott, Salenna R., Hodder, Anthony N., Marsh, Kevin, Mueller, Ivo, Mugyenyi, Cleopatra K., Osier, Faith, Richards, Jack S., Senn, Nicolas, Siba, Peter M., Stanisic, Danielle I., Terheggen, Ulrich   +16 more
core   +1 more source

Malaria transmission blocking immunity and sexual stage vaccines for interrupting malaria transmission in Latin America

Memorias do Instituto Oswaldo Cruz, 2011
Malaria is a vector-borne disease that is considered to be one of the most serious public health problems due to its high global mortality and morbidity rates.
Myriam Arévalo-Herrera, Yezid Solarte, Catherin Marin, Mariana Santos, Jenniffer Castellanos, John C Beier, Sócrates Herrera Valencia   +6 more
doaj   +1 more source

Randomized, Controlled Trial of the Long Term Safety, Immunogenicity and Efficacy of RTS,S/AS02(D) Malaria Vaccine in Infants Living in a Malaria-Endemic Region. [PDF]

, 2013
The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization.
A Olotu, Ali Mohammed, Amanda Leach, B Lell, David Schellenberg, E Macete, EV Macete, Francisca Machera, Grace Mwangoka, Hassan Mshinda, J Sacarlal, J Sacarlal, JJ Aponte, Joe Cohen, Johan Vekemans, KA Bojang, KE Kester, KP Asante, Marc Lievens, Marcel Tanner, Marie-Claude Dubois, MedDRA, MT White, Mwanajaa Shomari, Nahya Salim, Omar Juma, P Aide, P Aide, P Bejon, Richard Kamata, S Abdulla, S Owusu-Agyei, Salim Abdulla, ST Agnandji, ST Agnandji, ST Agnandji, Sulende Kubhoja, Terrell Carter, Thomas Aebi, Tonya Villafana, W Ripley Ballou, WHO, WHO, WHO/IVR   +43 more
core   +5 more sources

Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques

Malaria Journal, 2017
Background Mild to severe anaemia is a common complication of malaria that is caused in part by insufficient erythropoiesis in the bone marrow. This study used systems biology to evaluate the transcriptional and alterations in cell populations in the ...
Yan Tang, Chester J. Joyner, Monica Cabrera-Mora, Celia L. Saney, Stacey A. Lapp, Mustafa V. Nural, Suman B. Pakala, Jeremy D. DeBarry, Stephanie Soderberg, the MaHPIC Consortium, Jessica C. Kissinger, Tracey J. Lamb, Mary R. Galinski, Mark P. Styczynski   +13 more
doaj   +1 more source

Optimization of parasite DNA enrichment approaches to generate whole genome sequencing data for Plasmodium falciparum from low parasitaemia samples

Malaria Journal, 2020
Background Owing to the large amount of host DNA in clinical samples, generation of high-quality Plasmodium falciparum whole genome sequencing (WGS) data requires enrichment for parasite DNA.
Zalak Shah, Matthew Adams, Kara A. Moser, Biraj Shrestha, Emily M. Stucke, Miriam K. Laufer, David Serre, Joana C. Silva, Shannon Takala-Harrison   +8 more
doaj   +1 more source

Immunoreactivity of Sera From Low to Moderate Malaria-Endemic Areas Against Plasmodium vivax rPvs48/45 Proteins Produced in Escherichia coli and Chinese Hamster Ovary Systems

Frontiers in Immunology, 2021
P48/45 is a conserved gametocyte antigen involved in Plasmodium parasite fertilization. A recombinant Plasmodium vivax P48/45 (Pvs48/45) protein expressed in Escherichia coli (E.
Myriam Arévalo-Herrera, Myriam Arévalo-Herrera, Kazutoyo Miura, Nora Cespedes, Carlos Echeverry, Eduardo Solano, Angélica Castellanos, Juan Sebastián Ramirez, Adolfo Miranda, Andrey V. Kajava, Carole Long, Giampietro Corradin, Sócrates Herrera, Sócrates Herrera   +13 more
doaj   +1 more source