Results 41 to 50 of about 106,967 (273)
The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication [PDF]
, 2011 By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication.
Breman, JG +6 more
core +1 more source
Scientific Reports, 2022 Novel approaches for malaria prophylaxis remain important. Synthetic DNA-encoded monoclonal antibodies (DMAbs) are a promising approach to generate rapid, direct in vivo host-generated mAbs with potential benefits in production simplicity and ...
Nicholas J. Tursi +12 more
doaj +1 more source
MethodsX, 2021 Profiling of serological responses to establish the landscape of antibody specificities in individuals exposed to pathogens or vaccines is crucial for (a) revealing humoral immune correlates of protection; (b) uncovering markers of pathogen exposure; and
Jessica Bolton +7 more
doaj +1 more source
Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies. [PDF]
, 2010 BACKGROUND: Over the past decade malaria intervention coverage has been scaled up across Africa. However, it remains unclear what overall reduction in transmission is achievable using currently available tools.
Basáñez, María-Gloria +10 more
core +6 more sources
Scientific Reports, 2017 A recent study of the RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase in efficacy from 50–60% to 80% when using a delayed fractional dose regimen, in which the standard 0–1–2 month immunization ...
Sidhartha Chaudhury +8 more
doaj +1 more source
Malaria Journal, 2018 Background Human-immune-system humanized mouse models can bridge the gap between humans and conventional mice for testing human vaccines. The HLA-expressing humanized DRAGA (HLA-A2.HLA-DR4.Rag1KO.IL2RγcKO.NOD) mice reconstitute a functional human-immune ...
Sai Majji +4 more
doaj +1 more source
Integrated Serologic Surveillance of Population Immunity and Disease Transmission. [PDF]
, 2018 Antibodies are unique among biomarkers in their ability to identify persons with protective immunity to vaccine-preventable diseases and to measure past exposure to diverse pathogens. Most infectious disease surveillance maintains a single-disease focus,
Arnold, Benjamin F +3 more
core +1 more source
Allelic forms of merozoite surface protein-3 in Plasmodium falciparum isolates from southeast of Iran [PDF]
, 2014 Background: Genetic diversity has provided Plasmodium falciparum with the potential capacity of avoiding the immune response, and possibly supported the natural selection of drug or vaccine-resistant parasites.
Ebrahimzadeh, A. +2 more
core +2 more sources
The Lancet, 2004 Large gains in the reduction of malaria mortality in the early 20th century were lost in subsequent decades. Malaria now kills 2-3 million people yearly. Implementation of malaria control technologies such as insecticide-treated bednets and chemotherapy could reduce mortality substantially, but an effective malaria vaccine is also needed.
Moorthy, V, Good, M, Hill, A
openaire +3 more sources
The rise of companies from emerging markets in global health governance: opportunities and challenges [PDF]
, 2014 The article analyses the involvement of pharmaceutical companies from emerging markets in global health governance. It finds that they play a central role as low-cost suppliers of medicines and vaccines and, increasingly, new technologies.
ANNE ROEMER-MAHLER +23 more
core +1 more source