Results 61 to 70 of about 106,967 (273)

Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria [PDF]

, 2015
BACKGROUND Sporozoite immunization of animals and humans under a chemo-prophylactic cover of chloroquine (CPS-CQ) efficiently induces sterile protection against malaria.
Bijker, Else M, Cockburn, Ian, Nganou-Makamdop, Krystelle, Sauerwein, Robert W, van Gemert, Geert-Jan, Zavala, Fidel   +5 more
core   +2 more sources

Differences in cynomolgus macaque populations used for infectious disease research

Animal Models and Experimental Medicine, EarlyView.
Cynomolgus macaques, a species of Old World primate native to southeastern and eastern Asia and the island of Mauritius, are one of the most important nonhuman primate models for infectious disease. Research into the population genetics of cynomolgus macaques has found significant differences between macaques native to different areas, particularly ...
Darcy Quist, Kimimuepigha Ebisine, Emma Kennedy, Stuart Dowall, Mike Dennis   +4 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Wild Animal Suffering Is Not Intractable: A Precautionary Approach to Compassionate Intervention

Journal of Applied Philosophy, EarlyView.
ABSTRACT Wild animals suffer due to human activity, yet natural factors contribute far more significantly to their suffering. In light of this, some propose that we have a pro tanto obligation to intervene in ecosystems to improve wild animal welfare.
Tristan Katz
wiley   +1 more source

Translational repression in malaria sporozoites

Microbial Cell, 2016
Malaria is a mosquito-borne infectious disease of humans and other animals. It is caused by the parasitic protozoan, Plasmodium. Sporozoites, the infectious form of malaria parasites, are quiescent when they remain in the salivary glands of the Anopheles
Oliver Turque, Tiffany Tsao, Thomas Li, Min Zhang   +3 more
doaj   +1 more source

STRIDE: a command-line HMM-based identifier and sub-classifier of Plasmodium falciparum RIFIN and STEVOR variant surface antigen families

BMC Bioinformatics, 2022
Background RIFINs and STEVORs are variant surface antigens expressed by P. falciparum that play roles in severe malaria pathogenesis and immune evasion.
Albert E. Zhou, Zalak V. Shah, Katie R. Bradwell, James B. Munro, Andrea A. Berry, David Serre, Shannon Takala-Harrison, Timothy D. O’Connor, Joana C. Silva, Mark A. Travassos   +9 more
doaj   +1 more source

Vaccine innovation, translational research and the management of knowledge accumulation [PDF]

, 2012
What does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving ...
Andre, Archibugi, Aston, Baird, Baldwin, Bastien, Benison, Bentrup, Blume, Blume, Blume, Blume, Blume, Blume, Bodian, Bonu, Bryder, Burnet, Buse, Carter, Chase, Chataway, Connor, Constant, de Souza, Dosi, Douglas, Esparza, Feinberg, Fleck, Fujimura, Galambos, Gallagher, Garber, Gerschenkron, Girard, Griffin, Hacking, Hilleman, Hopkins, Hopkins, Hortsmann, IAVI, IOM, Kremer, Lanjouw, Marincola, Markel, Mays, McCoy, Mullan, Nelson, Nelson, Nichter, Nightingale, Nightingale, NIH, Ohid Yaqub, Ohka, Oshinsky, Paul, Paul Nightingale, Plotkin, Poltorak, Pérez-Cuevas, Racaniello, Rasti, Ren, Ridley, Robbins, Rogers, Rose, Rosenberg, Sabin, Schofield, Smith, Smith, Time, Time, Tomes, van Lente, Vernick, Vincenti, Weiss, West, Yaqub, Zinkernagel   +86 more
core   +2 more sources

The Cinderella tree, Quillaja saponaria – A soap story

PLANTS, PEOPLE, PLANET, EarlyView.
Our current understanding of plants has been shaped by the entwining of different cultures. The Chilean soapbark tree, traditionally valued as a source of natural soap, was shown by serendipitous research in France in the 1900s to produce compounds that can boost the immune response to vaccines.
Anne Osbourn
wiley   +1 more source

Profiling the antibody response of humans protected by immunization with Plasmodium vivax radiation-attenuated sporozoites

Scientific Reports
Malaria sterile immunity has been reproducibly induced by immunization with Plasmodium radiation-attenuated sporozoites (RAS). Analyses of sera from RAS-immunized individuals allowed the identification of P.
Mary Lopez-Perez, Aarti Jain, D. Huw Davies, Juan M. Vásquez-Jiménez, Sonia M. Herrera, José Oñate, Philip L. Felgner, Sócrates Herrera, Myriam Arévalo-Herrera   +8 more
doaj   +1 more source

Artemether-lumefantrine efficacy among adults on antiretroviral therapy in Malawi

Malaria Journal, 2023
Background When people with human immunodeficiency virus (HIV) infection (PWH) develop malaria, they are at risk of poor anti-malarial treatment efficacy resulting from impairment in the immune response and/or drug-drug interactions that alter anti ...
Wongani Nyangulu, Randy G. Mungwira, Titus H. Divala, Nginache Nampota-Nkomba, Osward M. Nyirenda, Andrea G. Buchwald, Jernelle Miller, Dominique E. Earland, Matthew Adams, Christopher V. Plowe, Terrie E. Taylor, Jane E. Mallewa, Joep J. van Oosterhout, Sunil Parikh, Matthew B. Laurens, Miriam K. Laufer, the TSCQ Study Team   +16 more
doaj   +1 more source