Results 71 to 80 of about 106,967 (273)

TRIPS and knowledge diffusion from low‐ and middle‐income countries

Strategic Management Journal, EarlyView.
Abstract Research Summary We examine a significant yet underappreciated effect of IPR implementation: the dissemination after TRIPS implementation of established scientific knowledge from low‐ and middle‐income countries (LMICs) into the global scientific system of pharmaceutical development.
Michael Blomfield, Anita M. McGahan, Keyvan Vakili   +2 more
wiley   +1 more source

Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine

npj Vaccines, 2023
A malaria vaccine that blocks parasite transmission from human to mosquito would be a powerful method of disrupting the parasite lifecycle and reducing the incidence of disease in humans.
Thayne H. Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D. Salinas, Jen C. C. Hume, Lynn E. Lambert, Patrick E. Duffy, Niraj H. Tolia   +11 more
doaj   +1 more source

Epidemiology of Malaria in an Area Prepared for Clinical Trials in Korogwe, North-eastern Tanzania. [PDF]

, 2009
Site preparation is a pre-requesite in conducting malaria vaccines trials. This study was conducted in 12 villages to determine malariometric indices and associated risk factors, during long and short rainy seasons, in an area with varying malaria ...
Acleus S Rutta, AE Mnzava, AM Ronn, Bruno P Mmbando, CA Maxwell, CJ Drakeley, CJ Drakeley, Deus S Ishengoma, DG Heppner Jr, E Kahigwa, Filbert Francis, H Dirren, Hamisi A Msangeni, J Keiser, JC Beier, JG Siri, JP Lusingu, JP Lusingu, JP Shott, KN Suh, M Alifrangis, Martha M Lemnge, Mathias L Kamugisha, Method D Segeja, Misago D Seth, PB Bloland, R Bodker, R Bodker, RW Snow, S Vyas, Samwel H Sembuche, V Robert, WL Kilama, WL Kilama   +33 more
core   +3 more sources

Decoding pH‐Driven Phase Transition of Lipid Nanoparticles

Small, EarlyView.
Ionizable aminolipids govern lipid nanoparticle (LNP) function through environment‐dependent protonation. Constant‐pH molecular dynamics reveal intrinsic, apparent, and surface pKa${\rm pK}_{\text{a}}$ values within LNP‐mimetic membranes, demonstrating that the LNP lipid environment induces a pronounced downward pKa${\rm pK}_{\text{a}}$ shift exceeding
Marius F.W. Trollmann, Rainer A. Böckmann   +1 more
wiley   +1 more source

Recent advances in malaria genomics and epigenomics [PDF]

, 2016
Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian, Power, B. Joanne, Waters, Andrew P.   +2 more
core   +1 more source

Vaccine strategy when the smallpox model fails: 1. immune cognition, Malaria and the Fulani [PDF]

, 2001
We begin to examine the implications of IR Cohen's work on immune cognition [1-3] for vaccine strategies when simple elicitation of sterilizing immunity fails, as is the case for HIV, tuberculosis, and malaria.
Wallace, Robert G, Wallace, Rodrick
core  

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Development and Qualification of an Antigen Integrity Assay for a Plasmodium falciparum Malaria Transmission Blocking Vaccine Candidate, Pfs230

Vaccines, 2022
During development of a subunit vaccine, monitoring integrity of the recombinant protein for process development and quality control is critical. Pfs230 is a leading malaria transmission blocking vaccine candidate and the first to reach a Phase 2 ...
Kazutoyo Miura, Thao P. Pham, Shwu-Maan Lee, Jordan Plieskatt, Ababacar Diouf, Issaka Sagara, Camila H. Coelho, Patrick E. Duffy, Yimin Wu, Carole A. Long   +9 more
doaj   +1 more source

The Burden of Rabies in Tanzania and Its Impact on Local\ud Communities [PDF]

, 2013
Rabies remains a major public health threat in many parts of the world and is responsible for an estimated 55,000 human deaths annually. The burden of rabies is estimated to be around US$20 million in Africa, with the highest financial expenditure being ...
Cleaveland, Sarah, Ferguson, Heather, Hampson, Katie, Lembo, Tiziana, Sambo, Maganga, Simon, Cleophas, Urassa, Honorati   +6 more
core   +3 more sources

Global Interdependence, Just Vaccine Allocation, and Compensatory Justice: A New Model

Developing World Bioethics, EarlyView.
ABSTRACT During the COVID‐19 pandemic, numerous models were offered for how scarce vaccine resources should be distributed. Proposed vaccine distribution models generally were divided between nationalist models, which give preference to nationals, and cosmopolitan models, which ignore national boundaries.
Kalen J. Fredette
wiley   +1 more source