Results 121 to 130 of about 25,729 (205)

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Development of a Disease‐Specific Virtual Malaria Population for Physiologically‐Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Malaria remains a major global health challenge, with an urgent need for new therapies to combat the evolving resistance to anti‐malarial treatments. Physiologically‐based pharmacokinetic (PBPK) modeling offers a promising approach to accurately predict PK, optimize dosing strategies, reduce development time and cost, and de‐risk the ...
Junjie Ding, Qi Pei, Richard M. Hoglund, Joel Tarning   +3 more
wiley   +1 more source

Searching for the beasts in the archive as methodological praxis

Geographical Research, Volume 64, Issue 3, August 2026.
This article offers searching for the beasts in the archive as a methodological tool available to researchers invested in both anticolonialism and antianthropocentrism. By focusing on three basic units of reference—categories, histories, and borders—the article shows how searching for the beasts unsettles some taken‐for‐granted assumptions that ...
Senel Wanniarachchi
wiley   +1 more source

Improving Malaria Parasite Gene Flow Inference Under Sparse Spatial Sampling

Molecular Ecology Resources, Volume 26, Issue 6, August 2026.
ABSTRACT Estimating malaria parasite migration is crucial for informing elimination strategies, particularly by identifying regions with higher parasite migration that may serve as transmission sources and intervention targets. Methods that infer spatial variations in gene flow from georeferenced genetic data, including Estimated Effective Migration ...
Yao Li, Bing Guo, Timothy D. O'Connor, Shannon Takala‐Harrison, Kathleen Stewart   +4 more
wiley   +1 more source

Pre-clinical study of iron oxide nanoparticles fortified artesunate for efficient targeting of malarial parasite. [PDF]

EBioMedicine, 2019
Kannan D, Yadav N, Ahmad S, Namdev P, Bhattacharjee S, Lochab B, Singh S.   +6 more
europepmc   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, Volume 81, Issue 8, Page 2675-2712, August 2026.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Quantitative and Clinical Pharmacology Perspectives on Next‐Generation Malaria Prevention Using Vaccines and Long‐Acting Monoclonal Antibodies

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Malaria remains a significant global health burden, particularly among pediatric populations in endemic regions. Recent advances in preventive interventions highlight the complementary roles of vaccines and long‐acting monoclonal antibodies (mAbs) in reducing infection risk.
Sabiha R. Mim, Leonardo C. Xavier, Francine J. Azeredo, Sihem Ait‐Oudhia   +3 more
wiley   +1 more source

Eco‐Evolutionary Dynamics of Pathogen Epidemic Timing in a Seasonal Environment

Ecology Letters, Volume 29, Issue 8, August 2026.
How are seasonal patterns of pathogen epidemics shaped by evolution? Using numerical and analytical approaches, we investigate the evolution of pathogen seasonal preferences. Our analysis identifies two selective forces driving the diversification of pathogen seasonality: seasonal priority effect and stabilising selection.
Ryuichi Kumata, Akira Sasaki
wiley   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Hematology and Serum Biochemistry Reference Intervals for Captive‐Born Owl Monkeys (Aotus nancymae): Effects of Age and Sex

Journal of Medical Primatology, Volume 55, Issue 4, August 2026.
ABSTRACT Background Owl monkeys (Aotus spp.) are a nocturnal nonhuman primate (NHP) native to central and South America that are used as infectious disease research models for human diseases, such as malaria and human immunodeficiency virus. Natural and infectious diseases may cause alterations in the hematology and serum biochemistry values, which ...
Sarah M. Kezar, Sarah J. Neal, Gregory K. Wilkerson   +2 more
wiley   +1 more source