Results 71 to 80 of about 236,694 (244)

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

eLife, 2014
Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies.
Wilson Wong, Xiao-chen Bai, Alan Brown, Israel S Fernandez, Eric Hanssen, Melanie Condron, Yan Hong Tan, Jake Baum, Sjors HW Scheres   +8 more
doaj   +1 more source

Long‐term impact of exposure to Royal Guard, a pyriproxyfen‐based bed net, on pyrethroid‐resistant malaria vectors from Cameroon using DNA‐based metabolic resistance markers

Pest Management Science, Volume 81, Issue 4, Page 2165-2180, April 2025.
We used recently detected P450 DNA‐based markers of pyrethroid resistance in both Anopheles funestus and Anopheles gambiae to demonstrate that although pyrethroid‐resistant mosquitoes have higher ability to survive and live longer after exposure to Royal Guard, this net significantly affects their lifespan, blood feeding ability and interestingly ...
Emilie S Ngongang‐Yipmo, Magellan Tchouakui, Benjamin D Menze, Riccado F Tiomela, Derrick Fofie, Vanessa B Ngannang‐Fezeu, Jean L Mugenzi, Flobert Njiokou, Charles S Wondji   +8 more
wiley   +1 more source

Balancing in a black box: Potential immunomodulatory roles for TGF-β signaling during blood-stage malaria

Virulence, 2020
Malarial disease caused by Plasmodium parasites challenges the mammalian immune system with a delicate balancing act. Robust inflammatory responses are required to control parasite replication within red blood cells, which if unchecked, can lead to ...
Lisa L. Drewry, John T. Harty
doaj   +1 more source

Right to Food in Sub‐Saharan Africa: Challenges, Policies, and Sustainable Strategies

Sustainable Development, EarlyView.
ABSTRACT This article examines the multifaceted issue of food security in Sub‐Saharan Africa and the critical importance of upholding rights to food in the region. It explores the challenges posed by food insecurity, analyzes existing policies and interventions, and proposes sustainable strategies to enhance food security.
Helen Onyeaka, Adenike A. Akinsemolu, Phemelo Tamasiga, Ogueri Nwaiwu, Elijah Kolawole Oladipo, Kehinde Abolade Aderibigbe, Taghi Miri   +6 more
wiley   +1 more source

The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission [PDF]

, 2009
1Infection of red blood cells (RBC) subjects the malaria parasite to oxidative stress. Therefore, efficient antioxidant and redox systems are required to prevent damage by reactive oxygen species. Plasmodium spp.
Vega-Rodríguez Joel, Franke-Fayard Blandine, Coppens Isabelle, Waters Andrew P., Dinglasan, R.R., Andrew P. Waters, Joel Vega-Rodríguez, Rhoel R. Dinglasan, Jacobs-Lorena Marcelo, José F Rodríguez-Orengo, Jacobs-Lorena, M., Rodríguez-Orengo José F., Blandine Franke-Fayard, Chris J. Janse, Vega-Rodriguez, J., Isabelle Coppens, José F. Rodríguez-Orengo, Serrano Adelfa E., Adelfa E. Serrano, Janse, C.J., Serrano, A.E., Rhoel R Dinglasan, Prakash Srinivasan, Waters, A., Adelfa E Serrano, Marcelo Jacobs-Lorena, Pastrana-Mena Rebecca, Janse Chris J., Chris J Janse, Dinglasan Rhoel R., Rodriguez-Orengo, J.F., Srinivasan, P., Pastrana-Mena, R., Rebecca Pastrana-Mena, Franke-Fayard, B., Andrew P Waters   +35 more
core   +2 more sources

The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites

Malaria Journal, 2008
Background Severe malarial anaemia is a major complication of malaria infection and is multi-factorial resulting from loss of circulating red blood cells (RBCs) from parasite replication, as well as immune-mediated mechanisms.
Lamb Tracey J, Langhorne Jean
doaj   +1 more source

Quantitative bioluminescent imaging of pre-erythrocytic malaria parasite infection using luciferase-expressing Plasmodium yoelii. [PDF]

PLoS ONE, 2013
The liver stages of Plasmodium parasites are important targets for the development of anti-malarial vaccine candidates and chemoprophylaxis approaches that aim to prevent clinical infection.
Jessica L Miller, Sara Murray, Ashley M Vaughan, Anke Harupa, Brandon Sack, Michael Baldwin, Ian N Crispe, Stefan H I Kappe   +7 more
doaj   +1 more source

Malarial parasites and antioxidant nutrients

Parasitology, 1993
SUMMARYSusceptibility to oxidative stress is a well-established feature of the malarial parasite. Pharmacologists have taken advantage of this property to design highly effective pro-oxidant antimalarial drugs. Less well appreciated is the fact that nutritional manipulation of host oxidative stress status by dietary means can have a profound effect on ...
O A, Levander, A L, Ager
openaire   +2 more sources

The consequences of host heterogeneity for parasite transmission depend on how host infectiousness is determined

Journal of Animal Ecology, EarlyView.
This study proposes two contrasting scenarios for how host infectiousness is determined: recipient dependence and donor dependence. These scenarios fundamentally alter how host heterogeneity shapes parasite transmission, demonstrating that the process by which infectiousness is determined is crucial for understanding the consequences of host ...
Jacob A. Cohen, Andrew D. Dean, Mark Viney, Andy Fenton   +3 more
wiley   +1 more source

EFFECT OF AYURVEDIC TREATMENT IN CHRONIC MALARIA: A CASE STUDY

Journal of Ayurveda and Holistic Medicine, 2013
Malaria is one of the main reasons for the cases of Pyrexia of Unknown Origin in modern days. In this case, a Male patient, aged 48 years presented with features of Pain in legs and lassitude for a long time.
Umesh Kumar Sapra
doaj