Results 61 to 70 of about 236,694 (244)

Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance. [PDF]

, 2010
BACKGROUND: Artemisinin-based combination therapy, currently considered the therapy of choice for uncomplicated Plasmodium falciparum malaria in endemic countries, may be under threat from newly emerging parasite resistance to the artemisinin family of ...
Khalid B Beshir, Hallett, Rachel L, Eziefula Alice C, Sutherland Colin J, Julie Watson, Polley Spencer D, Bailey Robin, Stephen G Wright, Chiodini Peter L, Chiodini, Peter L, Sutherland, Colin J, Bailey, Robin, Spencer D Polley, Beshir Khalid B, Wright Stephen G, Watson, Julie, Polley, Spencer D, Peter L Chiodini, Eziefula, Alice C, Watson Julie, Wright, Stephen G, Beshir, Khalid B, Colin J Sutherland, Rachel L Hallett, Alice C Eziefula, Hallett Rachel L, Robin Bailey   +26 more
core   +1 more source

Evaluating predictive values of umbilical cord arterial lactate for adverse newborn outcomes among term‐births in northern Uganda: A cross sectional analytical study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 408-420, April 2025.
Abstract Objective Birth asphyxia is one of the leading causes of death for neonates worldwide. Lack of an objective cost effective test to predict poor newborn outcomes at birth affects the ability to respond appropriately. This study determined predictive values of umbilical cord arterial lactate in relation to adverse neonatal outcomes. Methods This
Elizabeth Ayebare, James K. Tumwine, Jolly Nankunda, Anna Hjelmstedt, Wibke Jonas, Grace Ndeezi, Nicola Orsini, Claudia Hanson   +7 more
wiley   +1 more source

Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite [PDF]

, 1999
Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are currently our major hope in the fight against drug-resistant malaria.
Pandey, Amit V., Singh, Ram L., Chauhan, Virander S., Tekwani, Babu L., Pandey, Amit Vikram   +4 more
core   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection [PDF]

, 2015
During intra-erythrocytic development, late asexually replicating Plasmodium falciparum parasites sequester from peripheral circulation. This facilitates chronic infection and is linked to severe disease and organ-specific pathology including cerebral ...
Joice, Regina, Barteneva, Natasha S, Seydel, Karl B., Narasimhan, Vagheesh, Ma, Siyuan, Taylor, Terrie E., Pelle, Karell G, Milner, Danny A, Seydel, Karl B, Pelle, Karell G., Ketman, Ken, Brancucci, Nicolas Mb, Voss, Till S, Milner, Danny A., Pelle, Karell, Buchholz, Kathrin, Voss, Till S., Brancucci, Nicolas, Milner, Danny, Taylor, Terrie E, Huttenhower, Curtis, Marti, Matthias, Oh, Keunyoung, Barteneva, Natasha S.   +23 more
core   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Aquatic Diversity and Fishing Practices at Tell Tayinat (Türkiye) in the Iron Age

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT While agrarian societies of the Iron Age Eastern Mediterranean relied predominantly on crops and herding of domestic stock for subsistence, local wild aquatic fauna offered a welcomed enrichment, and when opportunities occurred, it could have been a staple in the human diet.
Radovan Kabatiar
wiley   +1 more source

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]

, 2010
<b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
Neils B Quashie, Lisa C Ranford-Cartwright, Ranford-Cartwright Lisa C, Harry P De Koning, De Koning, H.P., de Koning Harry P, Quashie Neils B, Quashie, N.B., Ranford-Cartwright, L.C.   +8 more
core   +1 more source