Results 151 to 160 of about 151,333 (388)

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Hypoxia‐Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated the effects of histone lactylation on ferroptosis in hypoxia‐induced cardiomyocytes. A hypoxia model was established in AC16 cells treated with 2‐Deoxy‐D‐glucose (2‐DG, a glucose analogue), ferrostatin‐1 (Fer‐1, a selective ferroptosis inhibitor), lactate (LA), sh‐β‐catenin (shRNA of β‐catenin), or SKL2001 (an agonist ...
Xin‐Hua Zhu, Jing‐Wen Hou, Zhong‐Ying Lv, Ming‐Hui Sun, Xiao‐Yang Zhang, Lei Zhang, Mei Wang   +6 more
wiley   +1 more source

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Role of the Mitochondrial Citrate-malate Shuttle in Hras12V-Induced Hepatocarcinogenesis: A Metabolomics-Based Analysis [PDF]

, 2020
Chuanyi Lei, Jun Chen, Huiling Li, Tingting Fan, Xu Zheng, Hong Wang, Nan Zhang, Yang Liu, Xiaoqin Luo, Jingyu Wang, Aiguo Wang   +10 more
openalex   +1 more source

A Self‐Healing Conductive PVP/SUM Hydrogel for Real‐Time Human Motion Detection

Nano Select, EarlyView.
The PVP/SUM hydrogel exhibits self‐healing, conductivity, and strong mechanical performance due to H‐bonds and dipole–dipole interactions. It elongates up to 330% and shows fracture strength between 0.9 and 1.5 MPa under varying strain rates. With a conductivity of 3.28 × 10−5 S/cm, it responds rapidly to human motion, enabling real‐time monitoring for
Vinnakoti Meghana, Illa Ramakanth
wiley   +1 more source

Exploration of the Phytochemical and Antidiabetic Properties of Teucrium polium: A Natural Asset for Type 2 Diabetes Management

ChemistryOpen, EarlyView.
Teucrium polium shows antidiabetic activity with its phytochemical composition and biological activities. The essential oil is rich in carvacrol, thymol, γ‐terpinene, and o‐cymene, while the aqueous and hydroethanolic extracts are characterized by poliumoside, verbascoside, isorhamnetin‐3‐O‐rutinoside, and apigenin‐7‐rutinoside. Antioxidant activity is
Hajar El Ouadni, Aziz Drioiche, Fadoua El Makhoukhi, Omkulthom Al kamaly, Hannou Zerkani, Smail Amalich, Imane Tagnaout, Mohamed Radi, Yahya Cherrah, Touriya Zair, Katim Alaoui   +10 more
wiley   +1 more source

Sunitinib malate for the treatment of pancreatic neuroendocrine tumors.

New England Journal of Medicine, 2011
E. Raymond, L. Dahan, J. Raoul, Y. Bang, I. Borbath, C. Lombard-Bohas, J. Valle, P. Metrakos, Denis Smith, A. Vinik, Jen‐Shi Chen, D. Hörsch, P. Hammel, B. Wiedenmann, E. Van Cutsem, S. Patyna, D. Lu, C. Blanckmeister, R. Chao, P. Ruszniewski   +19 more
semanticscholar   +1 more source

Malate Circulation: Linking Chloroplast Metabolism to Mitochondrial ROS.

Trends in Plant Science, 2020
Yannan Zhao, Hong Yu, Jian-Min Zhou, Steven M. L. Smith, Jiayang Li   +4 more
semanticscholar   +1 more source

Rhizosphere microbial detoxification and phosphorus solubilization drive ecological remediation of Pb–Zn contaminated soils

PLANTS, PEOPLE, PLANET, EarlyView.
Heavy metal contamination of soils poses a serious threat to ecosystem health and food security worldwide. This study investigated how native plants, such as Artemisia annua and Buddleja davidii, interact with soil microbes in Pb–Zn waste slag areas. We found that these plants stimulate microbes, which improve phosphorus availability and reduce metal ...
Caili Sun, Yajuan Yao, Yongwei Liu, Xiaoyu Lu   +3 more
wiley   +1 more source