ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Comparison of two MALDI-TOF MS platforms for identification of Trichosporon isolates from patients in a tertiary hospital in Hefei, China. [PDF]
Xu J +6 more
europepmc +1 more source
Recent Advances in Top‐Down Proteomics for Single‐Cell Research
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley +1 more source
A photocleavable peptidic Ru(ii) mass-tag enabling targeted DESI and MALDI mass spectrometry imaging in cancer tissues. [PDF]
Park M +8 more
europepmc +1 more source
Sequential MALDI-MSI-Based Multiomics Reveals Spatial Lipid, Glycan, and Tryptic Peptide Signatures in Breast Tumor Histopathology. [PDF]
Golestan SMJS +8 more
europepmc +1 more source
Association of Once-Daily MALDI-TOF MS Identification with Antibiotic Appropriateness and First-Modification Patterns in Emergency Department Bacteremia: A Retrospective Before-After Cohort Study. [PDF]
Lu JY, Wang YH, Tzeng SL, Lee YT, Wu TC.
europepmc +1 more source
Pulmonary Infection Caused by Mycolicibacterium neoaurum: The First Documented Case in Morocco. [PDF]
Oumloul A +4 more
europepmc +1 more source
Editorial: Navigating the microbial landscape: integrating mass spectrometry imaging and other multimodal imaging approaches for spatially resolved microbial studies. [PDF]
Tuck MD, Feucherolles M, Verhaert PDEM.
europepmc +1 more source
Integrated MALDI-MSI and UHPLC-OE-MS for Spatial Visualization and Biosynthetic Pathway Elucidation of Bioactive Metabolites in <i>Lilium lancifolium</i> Thunb. [PDF]
Deng Q +7 more
europepmc +1 more source
<i>Ignatzschineria larvae</i> bacteriemia in an intensive care unit patient: a case report and a review of the literature. [PDF]
Roudeau A +5 more
europepmc +1 more source

