Results 141 to 150 of about 316,007 (306)

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Incidence and mortality trends of male breast cancer in selected areas of Anhui province, 2010 - 2020: a cancer registry-based analysis

Zhongguo gonggong weisheng
ObjectiveTo analyze the incidence and mortality trends of male breast cancer in Anhui province from 2010 to 2020 based on cancer registry data, with the aim of developing prevention and control strategies for breast cancer in the population.
Dan DAI, Qiang ZHU, Wei XU, Yili LYU, Tingting DOU, Huadong WANG, Qinglian MENG   +6 more
doaj   +1 more source

Microarray analysis of tamoxifen resistance in breast cancer.

, 2009
PhDTamoxifen remains a widely used hormone therapy for pre and postmenopausal women with hormone receptor positive breast cancer in both adjuvant and metastatic disease settings. Resistance to this well tolerated and cost-effective drug limits its use.
Moss, Charlotte
core  

UK healthcare professionals’ experiences and perceptions of the support needs of men with breast cancer and their informal carers

Introduction: This study aimed to explore UK healthcare professionals’ perspectives on support for male breast cancer patients and their informal carers, and to identify avenues for improvement.
Herring, Beth, Harcourt, Diana, Lewis-Smith, Helena, Paraskeva, Nicole, Halliwell, Emma   +4 more
core   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

Phyllodes Tumor on Male Breast: A Literature Review

Indonesian Journal of Cancer
Background: Phyllodes tumor is a neoplasm from the fibroepithelial lesion and is rare to be found. Hence, there are some case reports that phyllodes tumor also can be found in the male breast. From 1990 until 2020, 13 articles show the phyllodes tumor in
Naufal Dzulhijar, Muhammad Yamsun
doaj   +1 more source

Expression of shelterin and shelterin-associated genes in breast cancer cell lines [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Mammalian telomeric DNA consists of tandem repeats of the sequence TTAGGG associated with a specialized set of proteins, known collectively as Shelterin ...
Motevalli, Azadeh
core  

PD-1 and PD-L1 Expression in Male Breast Cancer in Comparison with Female Breast Cancer

, 2018
Background: Male breast cancer is rare, as it represents less than 1% of all breast cancer cases. In addition, male breast cancer appears to have a different biology than female breast cancer.
Manson, Quirine F., Buerger, Horst, Moelans, Cathy B., van Diest, Paul J., ter Hoeve, Natalie D.   +4 more
core   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source