Results 61 to 70 of about 109,203 (279)

Ca2+ homeostasis and male fertility: a target for a new male contraceptive system

Animal Cells and Systems
Ca2+ is a key secondary messenger that determines sperm motility patterns. Mammalian sperm undergo capacitation, a process to acquire fertilizing ability, in the female reproductive tract.
Kyung-Ha Lee, Jae Yeon Hwang
doaj   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Male knowledge, attitude and practice and partner pregnancy among Chinese unmarried youth.

PLoS ONE, 2019
BACKGROUND:Early pregnancy among unmarried youth is a serious public health challenge. Male youth's knowledge, attitude and practice (KAP) of sexual and reproductive health (SRH) and its association with the risk of their sexual partners' pregnancy in ...
Ruoxi Ding, Chao Guo, Xinming Song, Xiaoying Zheng   +3 more
doaj   +1 more source

Can Sexuality Education Advance Gender Equality and Strengthen Education Overall? Learning from Nigeria's Family Life and HIV Education Program [PDF]

, 2015
The imperative to prepare the largest generation of young people in history for adulthood has driven a search for fresh approaches to educating adolescents about their bodies and sexuality.
Deborah Rogow, Susan Y. Wood
core  

Safety and Acceptability of Community-Based Distribution of Injectable Contraceptives: A Pilot Project in Mozambique. [PDF]

, 2016
Mozambique has witnessed a climbing total fertility rate in the last 20 years. Nearly one-third of married women have an unmet need for family planning, but the supply of family planning services is not meeting the demand. This study aimed to explore the
Bique, Cassimo, Blazer, Cassandra, Jacinto, Ana, Mobaracaly, Mahomed, Prata, Ndola, Ustáb, Momade, Weidert, Karen   +6 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

The Birth Control Divide : U. S. Press Coverage of Contraception, 1873-2013 [PDF]

, 2016
For more than 140 years, religious, medical, legislative, and legal institutions have contested the issue of contraception. In this conversation, predominantly male voices have attached reproductive rights to tangential moral and political matters ...
Garner, Ana C., Michel, Angela
core   +1 more source

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

KAP Study on Contraception of First Year Male Students in Khon Kaen University

Thai Journal of Obstetrics and Gynaecology, 2015
Objective:To study knowledge, attitude, and practice of the first year male Khon Kaen university students regarding to contraceptionMaterials and Methods:A cross sectional descriptive study was conducted, using anonymous self-administered questionnaires,
Khotchawan Supa, Lingling Salang, Yuthapong Werawatakul, Kovit Khampitak, Keerati Wattanakamolchai   +4 more
doaj   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source