Results 91 to 100 of about 2,064,575 (292)

The conventional management of male infertility

, 2013
Although the male reproductive function is impaired in about half of infertile couples, the evaluation of male infertility is underrated or neglected even today.
LENZI, Andrea, Eberhard Nieschlag, Andrea Lenzi   +2 more
core   +1 more source

Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. [PDF]

, 2006
Tumor suppressor of lung cancer 1 (TSLC1), also known as SgIGSF, IGSF4, and SynCAM, is strongly expressed in spermatogenic cells undergoing the early and late phases of spermatogenesis (spermatogonia to zygotene spermatocytes and elongating spermatids to
Arends, Mark J., Affara, Nabeel, Adams, David J., Ellis, Peter J.I., Bradley, Allan, Chausiaux, Oriane E., van der Weyden, Louise, Surani, M. Azim, Lange, Ulrike C., Murakami, Yoshinori   +9 more
core   +1 more source

Global, regional, and national prevalence and years lived with disability due to infertility, 1990–2021: Results from the Global Burden of Disease Study 2021

Chinese Medical Journal
. Background:. Infertility is a burdensome, often overlooked condition. This study aimed to investigate the global distribution and trends in the burden of infertility from 1990 to 2021. Methods:.
Rui Lin, Yuan Lin, Guangfu Jin, Qiufen Sun, Zhibin Hu, Yanjie Yin   +5 more
doaj   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Male Infertility

, 2011
The role of male-derived factors in infertility now receives increasing prominence, as investigations focus more on the couple, rather than solely the female partner.
Anne M. Jequier
core   +1 more source

Effects of Infertility Insurance Mandates on Fertility [PDF]

Infertility currently affects over 6 million individuals in the United States. While most health insurance plans nationwide do not cover infertility diagnoses or treatments, to date fifteen states have enacted some form of infertility insurance mandate ...
Lucie Schmidt
core   +2 more sources

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Redefining Male Factor Infertility: Toward a Novel Diagnostic and Therapeutic Classification- Preliminary Findings [PDF]

openBackground Male factor infertility (MFI) is estimated to contribute to 30-50% of cases of couple infertility. Although MFI impact on couple infertility is relevant, during infertility investigations it is often neglected or considered only through ...
MANETTI, MATILDA
core  

The Genetic Landscape of Male Factor Infertility and Implications for Men’s Health and Future Generations

Uro
Infertility is a significant global health issue, affecting 8–12% of couples of reproductive age, with male factor infertility contributing to 30–50% of cases.
Kristian Black, Sofie Ølgaard, Amelia A. Khoei, Clara Glazer, Dana A. Ohl, Christian Fuglesang S. Jensen   +5 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source