Results 101 to 110 of about 2,064,575 (292)

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Chromatin packaging anomalies and DNA damage in human sperm: their possible implications in the treatment of male factor infertility.

, 1997
The paper illustrates the relationships between chromatin packaging anomalies and DNA damage in human sperm and their possible implications in the treatment of male factor ...
BIZZARO D., MANICARDI, Gian Carlo, BIANCHI P. G., BIANCHI U., SAKKAS D.   +4 more
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Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

OUTCOME OF FOLLICLE-STIMULATING HORMONE (FSH) THERAPY IN MALE INFERTILITY

reservedBackground: Infertility affects 15-25% of couples globally and the male factor accounts for approximately 40-50% of the cases, presenting a significant challenge to reproductive health. Treatment options for male infertility are limited and often
MITEVA, TEODORA VENTSISLAVOVA
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Some of the Factors Involved in Male Infertility: A Prospective Review

International Journal of General Medicine, 2020
Emad Babakhanzadeh,1,2 Majid Nazari,1 Sina Ghasemifar,1 Ali Khodadadian1 1Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; 2Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical ...
Babakhanzadeh E, Nazari M, Ghasemifar S, Khodadadian A   +3 more
doaj  

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Effectiveness of Follicle-Stimulating Hormone Therapy in Idiopathic Male Infertility

reservedBackground: Infertility affects 15-25% of couples globally, with male factor contributing to approximately 40-50% of cases, a significant proportion of which are idiopathic.
SCAFA, RAFFAELE
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The prevalence of infertility and related factors in patients referred to infertility center in Besat hospital, Sanandaj, Iran

Chronic Diseases Journal, 2019
BACKGROUND: Infertility is considered as a prominent health care issue. The present study aimed to determine the prevalence rate of infertility and certain factors relevant to it.
Sholeh Shagheibi, Fariba Seyedoshohadaie, Ghobad Moradi, Azim Gholami, Samaneh Rouhi   +4 more
doaj  

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Health disparities and infertility: impacts of state-level insurance mandates [PDF]

Infertility is more common for non-Hispanic black women, non-Hispanic other race women, and Hispanic women than for non-Hispanic white women, and both infertility and impaired fecundity are more common for high school dropouts and high school graduates ...
Lucie Schmidt, Marianne Bitler
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