Results 121 to 130 of about 2,172,253 (294)
Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction
Advanced Science, EarlyView.In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng +12 more
wiley +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
The epidemiology of infertility: measurement, prevalence and an investigation of early life and reproductive risk factors [PDF]
Estimated to affect one in six couples in the UK, infertility is an issue of great public health importance. This thesis provides a critical overview of the methodological issues in defining and studying infertility, and investigates the epidemiology ...
Oakley, Laura Louise
core +1 more source
Advanced Science, EarlyView.HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun +12 more
wiley +1 more source
The World Journal of Men's HealthPurpose: In recent decades, the incidence of male infertility has been increasing annually. In clinical practice, the question of whether to supplement folic acid is common among patients. Given the limited guidelines and research on the impact of folic
Weizhuo Wang +8 more
doaj +1 more source
Advanced Science, EarlyView.Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin +9 more
wiley +1 more source
Advanced Science, EarlyView.Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang +14 more
wiley +1 more source
Contribution of various factors to male infertility: a prospective review [PDF]
Infertility is becoming a serious problem among present generation. It causes emotional instability and mental stress in affected couples. In half of the analysed cases, male factor infertility is the major contributor.
Bansal, Amrit Kaur
core +1 more source
Pharmacological Therapies for Male Infertility
Male factor infertility is a multifaceted problem that affects approximately 50% of couples suffering from infertility. Causes of male infertility include endocrine disturbances, gonadotoxins, genetic abnormalities, varicocele, malignancies, infections ...
Mostafa, Taymour +12 more
core +1 more source