Results 171 to 180 of about 3,525,982 (384)

Elderly Liver Grafts are More Susceptible to Ischemia‐Reperfusion After Prolonged Cold Ischemia than Grafts from Young Donors—An Ex Vivo Liver Machine Perfusion Analysis in Sprague Dawley Rats

Advanced Therapeutics, EarlyView.
This study investigates how donor age and cold ischemia time influence liver perfusion parameters and injury markers. Older livers are more susceptible to longer ischemia times displaying more tissue damage, and higher expression of oxidative stress and apoptosis‐related proteins than livers with shorter ischemia times.
Leonard Boerger, Kilian A. Walter, Anna S. Pietsch, Linda Gilles, Oliver Klein, Karl H. Hillebrandt, Joseph M. G. V. Gassner, Jasper Iske, Johann Pratschke, Felix Krenzien, Igor M. Sauer, Nathanael Raschzok, Simon Moosburner   +12 more
wiley   +1 more source

Next-Generation Sequencing Infertility Panel in Turkey: First Results

Balkan Journal of Medical Genetics
Male infertility is a complex pathophysiological disorder. At least 2000 genes are implicated in the etiology of male infertility, making it a very complex genetic condition. In cases of male infertility, genetic testing using next-generation sequencing (
Ikbal Atli E, Yalcintepe S, Atli E, Demir S, Gurkan H   +4 more
doaj   +1 more source

Microbial Dysbiosis and Male Infertility: Understanding the Impact and Exploring Therapeutic Interventions [PDF]

, 2023
Aris Kaltsas, Athanasios Zachariou, Eleftheria Markou, Fotios Dimitriadis, Nikolaos Sofikitis, Spyros Pournaras   +5 more
openalex   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Fertil Steril [PDF]

ObjectiveTo investigate the risk of preterm birth among liveborn singletons to primiparas who conceived with assisted reproductive technology (ART) using four mutually exclusive categories of infertility (female infertility only, male infertility only ...

core  

CFAP70 mutations lead to male infertility due to severe astheno-teratozoospermia. A case report

, 2019
Julie Beurois, Guillaume Martinez, Caroline Cazin, Zine‐Eddine Kherraf, Amir Amiri‐Yekta, Nicolas Thierry‐Mieg, Marie Bidart, Graciane Pètre, Véronique Satre, Sophie Brouillet, Aminata Touré, Christophe Arnoult, Pierre F. Ray, Charles Coutton   +13 more
openalex   +2 more sources

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Glutathione S-transferase P1 Ile105Val Polymorphism and Male Infertility Risk

, 2017
Xuekun Huang, Yonghan Huang, Juanhua Huang, Jingyao Liang   +3 more
openalex   +1 more source