Results 31 to 40 of about 2,172,253 (294)

Infertility in the light of new scientific reports – focus on male factor [PDF]

, 2016
Epidemiological data indicate that infertility is a problem of global proportions, affecting one- fifth of couples trying to conceive worldwide (60–80 mln).
Paweł Milart, Tomasz Paszkowski, Slawomir Wozniak, Piotr Czuczwar, Piotr Szkodziak, Wozniakowska, E., Milart, P., Ewa Wozniakowska, Mroczkowski, A., Paszkowski, T., Wozniak, S., Szkodziak, P., Ewa Wozniakowska, Piotr Czuczwar, Artur Mroczkowski, Artur Mroczkowski, Slawomir Wozniak, Tomasz Paszkowski, Paweł Milart, Czuczwar, P., Piotr Szkodziak   +20 more
core   +2 more sources

The Use of Non-Apoptotic Sperm Selected by Magnetic Activated Cell Sorting (MACS) to Enhance Reproductive Outcomes: What the Evidence Says

Biology
Sperm selection of the most competent sperm is a promising way to enhance reproductive outcomes. Apoptosis is the programmed cell death process to maintain tissue homeostasis, and MACS sperm selection of non-apoptotic cells enables the removal of ...
Nicolás Garrido, María Gil Juliá
doaj   +1 more source

Infertility in the Moroccan population: an etiological study in the reproductive health centre in Rabat

The Pan African Medical Journal, 2018
The causes of infertility vary widely and differ between regions and within countries. There is no report on this subject in Morocco. Therefore, the aim of this study was to determine the causes of infertility in Moroccan infertile couples and to compare
Amal Benbella, Siham Aboulmakarim, Houyam Hardizi, Asmaa Zaidouni, Rachid Bezad   +4 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Comparable Reproductive Outcomes of ICSI for Couples with Unexplained Infertility and Couples with Male Factor Infertility

Middle East Fertility Society Journal, 2018
Objective: The aim of this study was to compare intra-Cytoplasmic Sperm Injection (ICSI) outcomes (fertilization rate, embryo quality, pregnancy rate, and live birth rate) for couples with unexplained infertility and couples with male factor infertility,
Wardah Alasmari, Fawaz Edris, Zainab Albar, Mamdoh Eskandar, Camellia Sultan, Amer Alboush, Abdulaziz Alasmari   +6 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

The factors affecting male infertility: A systematic review [PDF]

, 2021
Background: In recent years, the incidence of male infertility has increased worldwide. It is necessary to study the factors that influence male infertility in each area/region for better management.
Mirzaiinajmabadi, K. (Khadigeh), Roudsari, Robab Latifnejad, Mirzaiinajmabadi, Khadigeh, Jafari, Hamideh, Rakhshkhorshid, M. (Marzieh), Latifnejad Roudsari, Robab, Rakhshkhorshid, Marzieh, Roudsari, R. L. (Robab), Jafari, H. (Hamideh), Hamideh Jafari, Marzieh Rakhshkhorshid, Robab Latifnejad Roudsari, Khadigeh Mirzaiinajmabadi, Robab Latifnejad Roudsari   +13 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source