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Male Infertility: The Process to Seeking Treatment [PDF]

, 2016
Infertility has an effect on both males and females. Current literature focuses on women rather than men. The purpose of this study was to gain an understanding of the process that adult males go through from deciding to conceive to seeking treatment for
Lawson, Michele
core   +3 more sources

Male Infertility [PDF]

, 2012
Male infertility is a multifaceted disease where genetic, epigenetic and environmental factors all contribute to the development of the phenotype. In recent years, there has been an increasing concern about a decline in reproductive health, paralleled by

core   +2 more sources

Male infertility and cytogenetics

Journal of Marine Medical Society, 2013
Genetic factors are found to play a major role in male infertility. Inf act, it has been suggested that a linear correlation exists between seminal defects and chromosomal abnormalities.
Pankaj Talwar, Bhavni Oberoi, Rana Bhim Sen, Sushil Kumar   +3 more
doaj   +1 more source

Association of CFAP65 rs56411706 with male infertility in 393 Vietnamese individuals

Vietnam Journal of Science, Technology and Engineering, 2022
Approximately two thousand genes have been found to be involved in spermatogenesis and their mutations have been reportedly associated with male infertility. Recent studies have shown that CFAP65 was crucial for spermatogenesis, and several mutations in
Thuy Duong Nguyen, Thi Khanh Ly Nguyen, Thi Thu Ha Duong   +2 more
doaj   +1 more source

Diagnosing male infertility

BMJ, 2018
### What you need to know Around 1 in 7 couples in the UK1 seek treatment for infertility when they are unable to conceive, despite regular unprotected intercourse. Male infertility describes any factor in men that may prevent a couple from becoming pregnant. In nearly half of infertility cases, the male partner has suboptimal sperm parameters.23 Some
Wall, J, Jayasena, CN
openaire   +4 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A de novo paradigm for male infertility [PDF]

, 2022
De novo mutations are known to play a prominent role in sporadic disorders with reduced fitness. We hypothesize that de novo mutations play an important role in severe male infertility and explain a portion of the genetic causes of this understudied ...
Smith, H.E., Smith, Hannah E., Batty, L. E., Gonzaga-Jauregui, C., Omurtag, KR, Gonzaga-Jauregui, C, O'Bryan, M.K., Fernandes, Susana, Cockell, S., Gonçalves, J, Braat, DDM, Tüttelmann, F., Aston, Kenneth I., Nagirnaja, L, Friedrich, C., Lopes, Alexandra M., Carvalho, Filipa, Ramos, L, Almstrup, K, Fleischer, K., Jungheim, Emily S., Riera-Escamilla, A, Turner, H., Pinto, Graça, Ismail, H., Greenwood, J., Holt, GS, Oud, Manon S., Ramos, L., Correia, S, Laan, Maris, Gilissen, Christian, O’Bryan, M.K., Caetano, I, Alobaidi, Bilal K., Gonzaga-Jauregui, Claudia, Batty, L.E., Barros, Alberto, Barros, A, Schaafsma, E, Nagirnaja, L., Cockell, S, Smits, RM, D'Hauwers, K. W. M., Fernandes, S, Santibanez-Koref, M, Vissers, LELM, Mikulasova, A, Astuti, G. D. N., Smits, Roos M., McLachlan, Rob, Riera-Escamilla, A., Coxhead, J, Jørgensen, Niels, Alobaidi, BKS, Turner, H, Correia, Sónia, Jenkins, TG, McEleny, K, Sheth, Harsh, Punab, Margus, Coxhead, Jonathan, Meyts, Ewa Rajpert-De, Sandlow, JI, Jungheim, ES, Jarvi, KA, Sheth, H., Aston, K.I., Riera-Escamilla, Antoni, Krausz, Csilla, Caetano, Iris, Gilissen, C., Mastrorosa, Francesco Kumara, Hotaling, James M., Oud, MS, Braat, Didi, Jarvi, Keith A., Schlegel, Peter N., Aston, KI, Gonçalves, João, van der Heijden, GW, Carvalho, F, Vissers, L.E.L.M., Nagirnaja, Liina, Oud, M.S., Eisenberg, ML, Conrad, Donald F., Ismail, H, Kliesch, Sabine, Tüttelmann, Frank, Seixas, Susana, Krausz, Csilla G., D’Hauwers, KWM, van der Heijden, G.W., Smits, R.M., Kliesch, S, de Vries, P. F., van der Heijden, G. W., D'Hauwers, K.W.M., Astuti, G.D.N., McLachlan, R, Houston, BJ, Houston, B.J., Punab, M, O'Bryan, Moira Kathleen, Braat, D.D.M., Xavier, MJ, Conrad, DF, Sheth, H, Ramos, Liliana, Seixas, S, Elliott, D. J., Elliott, D.J., Elliott, DJ, Santibanez-Koref, M., Xavier, Miguel, Pinto, G, Hotaling, JM, Schlegel, PN, Houston, Brendan J., Carrell, DT, Xavier, M.J., Friedrich, C, Kliesch, S., Mikulasova, A., Holt, Giles S., de Vries, PF, Jenkins, Timothy G., Almstrup, Kristian, Astuti, G.D.N, Conrad, D.F., Meyts, ERD, O’Bryan, Moira K., Lopes, AM, Vissers, Lisenka, Coxhead, J., Sandlow, Jay I., Greenwood, J, O’Bryan, MK, Schaafsma, E., Batty, LE, Tüttelmann, F, Eisenberg, Michael L., McEleny, K., Astuti, GDN, Carrell, Douglas T., Veltman, Joris A., D’Hauwers, K.W.M., Smith, HE, Veltman, JA, Heijden, G.W. van der, Krausz, CG, Jørgensen, N, Krausz, C., Omurtag, Kenan R., Veltman, J.A., Gilissen, C, Vries, P.F. de, de Vries, P.F., Alobaidi, B.K.S., Mastrorosa, F.K., Fleischer, K, Universitat Autònoma de Barcelona, Mastrorosa, FK, Holt, G.S., Laan, M   +165 more
core   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Male Tract Microbiota and Male Infertility

Cells
In recent years, several studies have analyzed the composition of the male genital tract microbiota and its changes in infertility or in different situations associated with infertility.
Giuseppe Grande, Andrea Graziani, Luca De Toni, Andrea Garolla, Alberto Ferlin   +4 more
doaj   +1 more source