Results 211 to 220 of about 221,321 (308)

COVID-19 and Male Reproduction: A Thorny Problem. [PDF]

Am J Mens Health, 2022
Li X, Chen Z, Geng J, Mei Q, Li H, Mao C, Han M.   +6 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Hydrogen sulfide and its potential as a possible therapeutic agent in male reproduction. [PDF]

Front Endocrinol (Lausanne)
Pilsova Z, Pilsova A, Zelenkova N, Klusackova B, Chmelikova E, Postlerova P, Sedmikova M.   +6 more
europepmc   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

The microRNA-mediated apoptotic signaling axis in male reproduction: a possible and targetable culprit in male infertility. [PDF]

Cell Biol Toxicol
Yu P, Zhao X, Zhou D, Wang S, Hu Z, Lian K, Zhang N, Duan P.   +7 more
europepmc   +1 more source

Water Blooms-A Potential Threat to Male Reproduction: Clues From Aquatics and Rodents. [PDF]

Front Endocrinol (Lausanne), 2022
Liu S, He B, Li H.
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

The Role of Retinoic Acid in Spermatogenesis and Its Application in Male Reproduction. [PDF]

Cells
Zhao Y, Deng S, Li C, Cao J, Wu A, Chen M, Ma X, Wu S, Lian Z.   +8 more
europepmc   +1 more source

Evidence of endogenously produced hydrogen sulfide (H₂S) and persulfidation in male reproduction. [PDF]

Sci Rep, 2022
Řimnáčová H, Moravec J, Štiavnická M, Havránková J, Monsef L, Hošek P, Prokešová Š, Žalmanová T, Fenclová T, Petr J, Králíčková M, Nevoral J.   +11 more
europepmc   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source