Results 141 to 150 of about 3,297,329 (340)

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao   +10 more
wiley   +1 more source

RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility

open access: yesAdvanced Science, EarlyView.
RAD21L1 is upregulated in human Sertoli cells to be transited to become spermatogonial stem cells by overexpressing DAZ family three genes. RAD21L1 is sufficient and effective for reprogramming Sertoli cells into human spermatogonial stem cells with high safety through DNA methylation.
Caimei He   +4 more
wiley   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser   +11 more
wiley   +1 more source

Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair

open access: yesAdvanced Science, EarlyView.
A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy