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The Quantitative Detection of Urogenital Mycoplasmas in Men with Urolithiasis [PDF]

open access: yesPathogens
Urease-positive urogenital mycoplasmas are considered to be responsible for the formation of urinary stones. They are usually a part of the normal flora in the human urogenital tract, causing asymptomatic infections.
Dominika Smolec   +7 more
doaj   +2 more sources

Gender aspects of epidemiology and laboratory diagnostics of urogenital trichomoniasis [PDF]

open access: yesСаратовский научно-медицинский журнал, 2013
Urogenital trichomoniasis is still one of the most common sexually transmitted diseases. Evolutionary vaginal Tricho-monas parazited initially in female genital tract, and later adapted to the conditions of the male genital tract. This contributed to the
Gorchakov D.A.   +3 more
doaj   +2 more sources

Community Knowledge, Perceptions, and Practices Associated with Urogenital Schistosomiasis among School-Aged Children in Zanzibar, United Republic of Tanzania [PDF]

open access: yes, 2016
Background: On the Zanzibar islands, United Republic of Tanzania, elimination of urogenital schistosomiasis is strived for in the coming years. This qualitative study aimed to better understand community knowledge, perceptions, and practices associated ...
A'Kadir, Faiza M.   +7 more
core   +14 more sources

m6A-mRNA Methylation Regulates Gene Expression and Programmable m6A Modification of Cellular RNAs With CRISPR-Cas13b in Renal Cell Carcinoma

open access: yesFrontiers in Genetics, 2022
Background: N6-methyladenosine (m6A) is the most extensive messenger RNA modification. Despite recent advances in the biological roles of m6A, its role in the development and progression of renal cell carcinoma (RCC) remains unclear.Methods: In this ...
Ying Gan   +17 more
doaj   +1 more source

Single-Cell RNA Sequencing of Human Corpus Cavernosum Reveals Cellular Heterogeneity Landscapes in Erectile Dysfunction

open access: yesFrontiers in Endocrinology, 2022
PurposeTo assess the diverse cell populations of human corpus cavernosum in patients with severe erectile dysfunction (ED) at the single-cell level.MethodsPenile tissues collected from three patients were subjected to single-cell RNA sequencing using the
Dong Fang   +35 more
doaj   +1 more source

Skimmed Bovine Milk-Derived Extracellular Vesicles Isolated via “Salting-Out”: Characterizations and Potential Functions as Nanocarriers

open access: yesFrontiers in Nutrition, 2021
Bovine milk-derived extracellular vesicles (BM-EVs) are recognized as promising nanoscale delivery vectors owing to their large availability. However, few isolation methods can achieve high purity and yield simultaneously. Therefore, we developed a novel
Xiao-Hui Tan   +31 more
doaj   +1 more source

TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma

open access: yesJournal of Experimental & Clinical Cancer Research, 2023
Background The management of advanced clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and the construction of more reliable prognostic prediction models and the further elucidation of key molecular mechanisms of ...
Yawei Xu   +11 more
doaj   +1 more source

Silencing of the TRIM58 Gene by Aberrant Promoter Methylation is Associated with a Poor Patient Outcome and Promotes Cell Proliferation and Migration in Clear Cell Renal Cell Carcinoma

open access: yesFrontiers in Molecular Biosciences, 2021
To investigate the underlying molecular mechanism of tripartite motif-containing 58 (TRIM58) in the development of clear cell renal cell carcinoma (ccRCC), we explored TRIM58 expression and methylation in tumor tissues and the association with ...
Ying Gan   +21 more
doaj   +1 more source

Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats [PDF]

open access: yesGeroScience, 2019
Dietary methionine restriction (MR) has been found to enhance longevity across many species. We hypothesized that MR might enhance longevity in part by delaying or inhibiting age-related disease processes. To this end, male Fischer 344 rats were fed control (CF, 0.86% methionine) or MR (0.17% methionine) diets throughout their life until sacrifice at ...
Despina Komninou   +4 more
openaire   +2 more sources

Cancer immunotherapies: advances and bottlenecks

open access: yesFrontiers in Immunology, 2023
Immunotherapy has ushered in a new era in cancer treatment, and cancer immunotherapy continues to be rejuvenated. The clinical goal of cancer immunotherapy is to prime host immune system to provide passive or active immunity against malignant tumors ...
Rui Rui   +11 more
doaj   +1 more source

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