Results 1 to 10 of about 16,602 (182)

m6A-mRNA Methylation Regulates Gene Expression and Programmable m6A Modification of Cellular RNAs With CRISPR-Cas13b in Renal Cell Carcinoma

open access: yesFrontiers in Genetics, 2022
Background: N6-methyladenosine (m6A) is the most extensive messenger RNA modification. Despite recent advances in the biological roles of m6A, its role in the development and progression of renal cell carcinoma (RCC) remains unclear.Methods: In this ...
Ying Gan   +17 more
doaj   +1 more source

Single-Cell RNA Sequencing of Human Corpus Cavernosum Reveals Cellular Heterogeneity Landscapes in Erectile Dysfunction

open access: yesFrontiers in Endocrinology, 2022
PurposeTo assess the diverse cell populations of human corpus cavernosum in patients with severe erectile dysfunction (ED) at the single-cell level.MethodsPenile tissues collected from three patients were subjected to single-cell RNA sequencing using the
Dong Fang   +35 more
doaj   +1 more source

TRAF2 promotes M2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear cell renal cell carcinoma

open access: yesJournal of Experimental & Clinical Cancer Research, 2023
Background The management of advanced clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and the construction of more reliable prognostic prediction models and the further elucidation of key molecular mechanisms of ...
Yawei Xu   +11 more
doaj   +1 more source

Skimmed Bovine Milk-Derived Extracellular Vesicles Isolated via “Salting-Out”: Characterizations and Potential Functions as Nanocarriers

open access: yesFrontiers in Nutrition, 2021
Bovine milk-derived extracellular vesicles (BM-EVs) are recognized as promising nanoscale delivery vectors owing to their large availability. However, few isolation methods can achieve high purity and yield simultaneously. Therefore, we developed a novel
Xiao-Hui Tan   +31 more
doaj   +1 more source

Silencing of the TRIM58 Gene by Aberrant Promoter Methylation is Associated with a Poor Patient Outcome and Promotes Cell Proliferation and Migration in Clear Cell Renal Cell Carcinoma

open access: yesFrontiers in Molecular Biosciences, 2021
To investigate the underlying molecular mechanism of tripartite motif-containing 58 (TRIM58) in the development of clear cell renal cell carcinoma (ccRCC), we explored TRIM58 expression and methylation in tumor tissues and the association with ...
Ying Gan   +21 more
doaj   +1 more source

Cancer immunotherapies: advances and bottlenecks

open access: yesFrontiers in Immunology, 2023
Immunotherapy has ushered in a new era in cancer treatment, and cancer immunotherapy continues to be rejuvenated. The clinical goal of cancer immunotherapy is to prime host immune system to provide passive or active immunity against malignant tumors ...
Rui Rui   +11 more
doaj   +1 more source

Transcriptome-Wide Map of N6-Methyladenosine Methylome Profiling in Human Bladder Cancer

open access: yesFrontiers in Oncology, 2021
N6-Methyladenosine (m6A) is the most widespread internal RNA modification in several species. In spite of latest advances in researching the biological roles of m6A, its function in the development and progression of bladder cancer remains unclear.
Aolin Li   +24 more
doaj   +1 more source

Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications

open access: yesFrontiers in Immunology, 2023
Renal cell carcinoma (RCC) is one of the most malignant urological tumors. Currently, there is a lack of molecular markers for early diagnosis of RCC.
Rui Rui   +11 more
doaj   +1 more source

Identification of the Six-RNA-Binding Protein Signature for Prognosis Prediction in Bladder Cancer

open access: yesFrontiers in Genetics, 2020
RNA-binding proteins (RBPs) are a kind of gene regulatory factor that presents a significant biological effect in the initiation and development of various tumors, including bladder cancer (BLCA).
Yucai Wu   +33 more
doaj   +1 more source

Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway

open access: yesFrontiers in Pharmacology, 2022
Background: Endothelial dysfunction is commonly accompanied by a reduced capacity for nitric oxide (NO) production and decreased NO sensitivity, playing a central role in numerous vascular diseases.
Yang-Yang Gu   +23 more
doaj   +1 more source

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