Results 141 to 150 of about 1,560,230 (391)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Malignancy in oral lichen planus: a review of a group from the Malaysian population [PDF]
, 2002 The objective of this study was to determine the socio-demography (age, race and gender) of a group of Malaysian patients who were diagnosed as suffering from oral lichen planus (OLP). The occurrence of malignancy was also investigated.
Ngeow, Dr. W.C.
core
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Treatment patterns and clinical outcomes for multiple myeloma in Korean patients: a database study
BMC CancerBackground The treatment landscape for multiple myeloma (MM) has significantly progressed in recent decades. Methods We analyzed the treatment patterns and clinical outcomes in Korean patients using data from the National Health Insurance Service ...
Junghyun Yoon +6 more
doaj +1 more source
Cancer Informatics, 2016 RECK is downregulated in many tumors, and forced RECK expression in tumor cells often results in suppression of malignant phenotypes. Recent findings suggest that RECK is upregulated after epithelial–mesenchymal transition (EMT) in normal epithelium ...
Zhipeng Wang +4 more
doaj +1 more source
THE CRONIN LOWE SERUM REACTION FOR MALIGNANCY [PDF]
, 1933 Julie A. Patterson, Joel T. Adler
openalex +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases
Nature CommunicationsFunctional tumor-specific CD8+ T cells are essential for effective anti-tumor immune response and immune checkpoint inhibitor therapy. Here we show that, compared to other organ sites, primary, metastatic liver tumors in murine models contain a higher ...
Rajiv Trehan +14 more
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
The Relation of the Degree of the Histological Malignancy to the Prognosis and Treatment of Carcinoma of the Uterine Cervix [PDF]
, 1927 Henry Schmitz
openalex +1 more source