Results 11 to 20 of about 1,657,236 (389)

Efficacy and Safety of Edoxaban in Patients With Active Malignancy and Atrial Fibrillation: Analysis of the ENGAGE AF‐TIMI 48 Trial [PDF]

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2018
Background Anticoagulation in patients with malignancy and atrial fibrillation is challenging because of enhanced risks for thrombosis and bleeding and the frequent need for invasive procedures. Data on direct oral antagonists in such patients are sparse.
Christina L. Fanola, C. Ruff, S. Murphy, James Jin, A. Duggal, Noe A. Babilonia, P. Sritara, M. Mercuri, P. Kamphuisen, E. Antman, E. Braunwald, R. Giugliano   +11 more
semanticscholar   +2 more sources

Phase I study of a multitargeted recombinant Ad5 PSA/MUC-1/brachyury-based immunotherapy vaccine in patients with metastatic castration-resistant prostate cancer (mCRPC)

Journal for ImmunoTherapy of Cancer, 2021
Background Antitumor vaccines targeting tumor-associated antigens (TAAs) can generate antitumor immune response. A novel vaccine platform using adenovirus 5 (Ad5) vectors [E1–, E2b–] targeting three TAAs—prostate-specific antigen (PSA), brachyury, and ...
Renee N Donahue, Jeffrey Schlom, James L Gulley, Ravi A Madan, Claudia Palena, Caroline Jochems, Shahrooz Rabizadeh, Patrick Soon-Shiong, Sheri McMahon, Julius Strauss, Marijo Bilusic, Fatima Karzai, Houssein Abdul Sater, Jennifer L Marté, Yo-Ting Tsai, Jason Redman, Charalampos Floudas   +16 more
doaj   +1 more source

Clinical and surgical outcomes of patients with peritoneal mesothelioma discussed at a monthly national multidisciplinary team video‐conference meeting

BJS Open, 2020
Background Peritoneal mesothelioma (PM) is a rare primary neoplasm of the peritoneum with an increasing incidence worldwide. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has shown promise as a treatment strategy.
A. Brandl, S. Westbrook, S. Nunn, E. Arbuthnot‐Smith, J. Mulsow, H. Youssef, N. Carr, A. Tzivanakis, S. Dayal, F. Mohamed, B.J. Moran, T. Cecil   +11 more
doaj   +1 more source

CDK4/6 inhibitors sensitize gammaherpesvirus-infected tumor cells to T-cell killing by enhancing expression of immune surface molecules

Journal of Translational Medicine, 2022
Background The two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), both downregulate immune surface molecules, such as MHC-I, ICAM-1, and B7-2, enabling them to evade T-cell and natural ...
Yiquan Wu, Prabha Shrestha, Natalie M. Heape, Robert Yarchoan   +3 more
doaj   +1 more source

Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation

Antioxidants, 2022
Most viruses encode their own proteases to carry out viral maturation and these often require dimerization for activity. Studies on human immunodeficiency virus type 1 (HIV-1), type 2 (HIV-2) and human T-cell leukemia virus (HTLV-1) proteases have shown ...
David A. Davis, Haydar Bulut, Prabha Shrestha, Hiroaki Mitsuya, Robert Yarchoan   +4 more
doaj   +1 more source

Indications for cytoreductive surgery plus HIPEC in patients with colorectal cancer and peritoneal metastasis. [PDF]

Iranian Journal of Colorectal Research, 2023
Comprehensive treatment (COMPT) consisting of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in selected patients with peritoneal metastasis (PM) from colorectal cancer (CRC).
Yutaka Yonemura, Haruaki Ishibashi, Akiyoshi Mizumoto, Takuji Fujita, Yang Liu, Satoshi Wakama, Syouzou Sako, Nobuyuki Takao, Toshiyuki Kitai, Kanji Katayama, Yasuyuki Kamada, Keizou Taniguchi, Daisuke Fujimoto   +12 more
doaj   +1 more source

Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs

Frontiers in Microbiology, 2021
Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5′ and 3′ ends have been joined, which confers protection from RNA exonucleases. We examined the expression
Takanobu Tagawa, Daniel Oh, Jerico Santos, Jerico Santos, Sarah Dremel, Guruswamy Mahesh, Thomas S. Uldrick, Robert Yarchoan, Vishal N. Kopardé, Vishal N. Kopardé, Joseph M. Ziegelbauer   +10 more
doaj   +1 more source

Follicular nodules (Thy3) of the thyroid: is total thyroidectomy the best option? [PDF]

, 2014
BACKGROUND: Identification of the best management strategy for nodules with Thy3 cytology presents particular problems for clinicians. This study investigates the ability of clinical, cytological and sonographic data to predict malignancy in ...
CALO', PIETRO GIORGIO, ERDAS, ENRICO, Medas F, NICOLOSI, ANGELO, Pisano G, Podda F, Santa Cruz R   +6 more
core   +1 more source

Impact of hematologic malignancy and type of cancer therapy on COVID-19 severity and mortality: lessons from a large population-based registry study

Journal of Hematology & Oncology, 2020
Background Patients with cancer have been shown to have a higher risk of clinical severity and mortality compared to non-cancer patients with COVID-19. Patients with hematologic malignancies typically are known to have higher levels of immunosuppression ...
J. García-Suárez, J. De la Cruz, Ángel Cedillo, P. Llamas, R. Duarte, V. Jiménez‐Yuste, J. Hernández‐Rivas, Rodrigo Gil-Manso, M. Kwon, P. Sánchez-Godoy, P. Martínez-Barranco, Blanca Colás-Lahuerta, P. Herrera, L. Benito-Parra, A. Alegre, A. Velasco, A. Matilla, María Concepción Aláez-Usón, Rafael Martos-Martínez, C. Martínez-Chamorro, Keina Susana-Quiroz, J. D. Del Campo, A. de la Fuente, R. Herráez, A. Pascual, E. Gómez, J. Pérez-Oteyza, E. Ruíz, A. Alonso, J. González-Medina, Lucía Núñez Martín-Buitrago, M. Canales, I. González-Gascón, María Carmen Vicente-Ayuso, S. Valenciano, M. Roa, Pablo Estival Monteliú, J. López-Jiménez, C. Escobar, Javier Ortiz-Martín, J. Díez-Martín, J. Martínez-López, Cristina Keina Mónica Estévez María-José Daniel Laura Laura Serí-Merino Queiroz-Cervantes Fernandez Peñalva-Mo, Cristina Serí-Merino, Keina Queiroz-Cervantes, Mónica Fernández, María-José Peñalva-Moreno, Daniel Naya-Errea, Laura Bermejo-Martínez, Laura Llorente-González   +49 more
semanticscholar   +1 more source

The effects of time valuation in cancer optimal therapies: a study of chronic myeloid leukemia [PDF]

, 2019
Background The mathematical design of optimal therapies to fight cancer is an important research field in today’s Biomathematics and Biomedicine given its relevance to formulate patient-specific treatments. Until now, however, cancer optimal therapies
Gutiérrez Díez, Pedro José
core   +2 more sources