Results 11 to 20 of about 654,876 (248)

Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation

Antioxidants, 2022
Most viruses encode their own proteases to carry out viral maturation and these often require dimerization for activity. Studies on human immunodeficiency virus type 1 (HIV-1), type 2 (HIV-2) and human T-cell leukemia virus (HTLV-1) proteases have shown ...
David A. Davis, Haydar Bulut, Prabha Shrestha, Hiroaki Mitsuya, Robert Yarchoan   +4 more
doaj   +1 more source

CDK4/6 inhibitors sensitize gammaherpesvirus-infected tumor cells to T-cell killing by enhancing expression of immune surface molecules

Journal of Translational Medicine, 2022
Background The two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), both downregulate immune surface molecules, such as MHC-I, ICAM-1, and B7-2, enabling them to evade T-cell and natural ...
Yiquan Wu, Prabha Shrestha, Natalie M. Heape, Robert Yarchoan   +3 more
doaj   +1 more source

Indications for cytoreductive surgery plus HIPEC in patients with colorectal cancer and peritoneal metastasis. [PDF]

Iranian Journal of Colorectal Research, 2023
Comprehensive treatment (COMPT) consisting of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in selected patients with peritoneal metastasis (PM) from colorectal cancer (CRC).
Yutaka Yonemura, Haruaki Ishibashi, Akiyoshi Mizumoto, Takuji Fujita, Yang Liu, Satoshi Wakama, Syouzou Sako, Nobuyuki Takao, Toshiyuki Kitai, Kanji Katayama, Yasuyuki Kamada, Keizou Taniguchi, Daisuke Fujimoto   +12 more
doaj   +1 more source

Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs

Frontiers in Microbiology, 2021
Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5′ and 3′ ends have been joined, which confers protection from RNA exonucleases. We examined the expression
Takanobu Tagawa, Daniel Oh, Jerico Santos, Jerico Santos, Sarah Dremel, Guruswamy Mahesh, Thomas S. Uldrick, Robert Yarchoan, Vishal N. Kopardé, Vishal N. Kopardé, Joseph M. Ziegelbauer   +10 more
doaj   +1 more source

High level of pre-treatment C-reactive protein to albumin ratio predicts inferior prognosis in diffuse large B-cell lymphoma

Scientific Reports, 2021
The C-reactive protein-to-albumin ratio (CAR) has not been assessed in diffuse large B cell lymphoma (DLBCL, the most common non-Hodgkin lymphoma). This retrospective study evaluated the prognostic value of CAR in 186 DLBCL patients. A CAR value of 0.158
Jongheon Jung, Hyewon Lee, Ja Yoon Heo, Myung Hee Chang, Eunyoung Lee, Weon Seo Park, Ju-Hyun Park, Hyeon-Seok Eom   +7 more
doaj   +1 more source

Malignant Mesothelioma [PDF]

Journal of the Royal Society of Medicine, 1989
Mesothelioma is a malignant tumour of the pleura or peritoneum caused by asbestos. It is increasing in frequency and the prognosis remains grim, with average survival around 1 year.Medical literature and personal experience.Amphibole fibres are far more potent than chrysotile in causing mesothelioma.A minority view suggests that mesotheliomas in those ...
openaire   +4 more sources

Thirty-three long-term survivors after cytoreductive surgery in patients with peritoneal metastases from colorectal cancer: a retrospective descriptive study

World Journal of Surgical Oncology, 2021
Background Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in selected patients with peritoneal metastasis (PM) from colorectal cancer (CRC).
Yasuyuki Kamada, Koya Hida, Haruaki Ishibashi, Shouzou Sako, Akiyoshi Mizumoto, Masumi Ichinose, Naveen Padmanabhan, Shinya Yoshida, Yutaka Yonemura   +8 more
doaj   +1 more source

Evaluating DNA Methylation in Random Fine Needle Aspirates from the Breast to Inform Cancer Risk

The Breast Journal, 2022
Introduction. Critical regulatory genes are functionally silenced by DNA hypermethylation in breast cancer and premalignant lesions. The objective of this study was to examine whether DNA methylation assessed in random fine needle aspirates (rFNA) can be
Kala Visvanathan, Ashley Cimino-Mathews, Mary Jo Fackler, Pritesh S. Karia, Christopher J. VandenBussche, Mikiaila Orellana, Betty May, Marissa J. White, Mehran Habibi, Julie Lange, David Euhus, Vered Stearns, John Fetting, Melissa Camp, Lisa Jacobs, Saraswati Sukumar   +15 more
doaj   +1 more source

Haploidentical transplantation using posttransplant cyclophosphamide as GVHD prophylaxis in patients over age 70

Blood Advances, 2019
: Hematologic malignancies in older people are unlikely to be cured with chemotherapy alone. Advances in allogeneic blood or marrow transplantation (alloBMT), especially nonmyeloablative (NMA) conditioning and the use of haploidentical donors, now make ...
Philip H. Imus, Hua-Ling Tsai, Leo Luznik, Ephraim J. Fuchs, Carol Ann Huff, Douglas E. Gladstone, Patrick Lowery, Richard F. Ambinder, Ivan M. Borrello, Lode J. Swinnen, Nina Wagner-Johnston, Christian B. Gocke, Syed Abbas Ali, F.Javier Bolaños-Meade, Ravi Varadhan, Richard J. Jones   +15 more
doaj   +1 more source

Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV–MCD) and the KSHV Inflammatory Cytokine Syndrome

Frontiers in Microbiology, 2012
Soon after the discovery of Kaposi sarcoma (KS)-associated herpesvirus (KSHV), it was appreciated that this virus was associated with most cases of multicentric Castleman disease (MCD) arising in patients infected with human immunodeficiency virus.
Mark N. Polizzotto, Thomas S. Uldrick, Duosha Hu, Robert Yarchoan   +3 more
doaj   +1 more source