Results 21 to 30 of about 786,247 (318)

CDK4/6 inhibitors sensitize gammaherpesvirus-infected tumor cells to T-cell killing by enhancing expression of immune surface molecules

Journal of Translational Medicine, 2022
Background The two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), both downregulate immune surface molecules, such as MHC-I, ICAM-1, and B7-2, enabling them to evade T-cell and natural ...
Yiquan Wu, Prabha Shrestha, Natalie M. Heape, Robert Yarchoan   +3 more
doaj   +1 more source

Phase I study of a multitargeted recombinant Ad5 PSA/MUC-1/brachyury-based immunotherapy vaccine in patients with metastatic castration-resistant prostate cancer (mCRPC)

Journal for ImmunoTherapy of Cancer, 2021
Background Antitumor vaccines targeting tumor-associated antigens (TAAs) can generate antitumor immune response. A novel vaccine platform using adenovirus 5 (Ad5) vectors [E1–, E2b–] targeting three TAAs—prostate-specific antigen (PSA), brachyury, and ...
Renee N Donahue, Jeffrey Schlom, James L Gulley, Ravi A Madan, Claudia Palena, Caroline Jochems, Shahrooz Rabizadeh, Patrick Soon-Shiong, Sheri McMahon, Julius Strauss, Marijo Bilusic, Fatima Karzai, Houssein Abdul Sater, Jennifer L Marté, Yo-Ting Tsai, Jason Redman, Charalampos Floudas   +16 more
doaj   +1 more source

Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid [PDF]

, 2012
Background Thyroid fine needle aspiration cytology (FNAC) is the standard diagnostic modality for thyroid nodules. However, it has limitations among which is the incidence of non-diagnostic results (Thy1).
Mehanna, Hisham M., Weickert, Martin O., Hisham Mehanna, Al Maqbali Talib, Tedla Miroslav, Weickert, Martin O, Talib Al Maqbali, Al Maqbali, Talib, Mehanna Hisham, Weickert Martin O., Martin O Weickert, Tedla, Miroslav, Mehanna, Hisham; id_orcid, Miroslav Tedla   +13 more
core   +1 more source

Indications for cytoreductive surgery plus HIPEC in patients with colorectal cancer and peritoneal metastasis. [PDF]

Iranian Journal of Colorectal Research, 2023
Comprehensive treatment (COMPT) consisting of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in selected patients with peritoneal metastasis (PM) from colorectal cancer (CRC).
Yutaka Yonemura, Haruaki Ishibashi, Akiyoshi Mizumoto, Takuji Fujita, Yang Liu, Satoshi Wakama, Syouzou Sako, Nobuyuki Takao, Toshiyuki Kitai, Kanji Katayama, Yasuyuki Kamada, Keizou Taniguchi, Daisuke Fujimoto   +12 more
doaj   +1 more source

Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs

Frontiers in Microbiology, 2021
Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5′ and 3′ ends have been joined, which confers protection from RNA exonucleases. We examined the expression
Takanobu Tagawa, Daniel Oh, Jerico Santos, Jerico Santos, Sarah Dremel, Guruswamy Mahesh, Thomas S. Uldrick, Robert Yarchoan, Vishal N. Kopardé, Vishal N. Kopardé, Joseph M. Ziegelbauer   +10 more
doaj   +1 more source

High level of pre-treatment C-reactive protein to albumin ratio predicts inferior prognosis in diffuse large B-cell lymphoma

Scientific Reports, 2021
The C-reactive protein-to-albumin ratio (CAR) has not been assessed in diffuse large B cell lymphoma (DLBCL, the most common non-Hodgkin lymphoma). This retrospective study evaluated the prognostic value of CAR in 186 DLBCL patients. A CAR value of 0.158
Jongheon Jung, Hyewon Lee, Ja Yoon Heo, Myung Hee Chang, Eunyoung Lee, Weon Seo Park, Ju-Hyun Park, Hyeon-Seok Eom   +7 more
doaj   +1 more source

Malignancy within a Tail Gut Cyst: A Case of Retrorectal Carcinoid Tumour [PDF]

, 2014
Purpose. Tailgut cysts with malignant transformation are rare entities. We discuss the diagnostic strategy and treatment of a malignancy within a tailgut cyst. Methods.
Abukar, AA, Steele, RJC, R. J. C. Steele, P. V. Patil, Abukar, A. A., A. A. Abukar, Patil, P. V., THAHA, MA, C. B. Lim, Lim, C. B., Ramsanahie, A., Carey, F, A. Ramsanahie, M. A. Thaha, Steele, R. J. C., Thaha, M. A., Ramsanahie, A, B. J. Parcell, F. Carey, Lim, CB, Patil, PV, Parcell, B. J.; id_orcid, Carey, F., Parcell, BJ   +23 more
core   +1 more source

The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combination with CA125 in the differential diagnosis of ovarian masses [PDF]

, 2011
Background: Cancer antigen 125 (CA125) is the best known single tumor marker for ovarian cancer (OC). We investigated whether the additional information of the human epididymis protein 4 (HE4) improves diagnostic accuracy.
Fuerst, Sophie, Lenhard, Miriam, Katja Krocker, Karin Hofmann, Linda Hertlein, Sophie Fürst, Dorothea Nagel, Mayr, Doris, Hofmann, Karin, Alexander Burges, Stieber, Petra, Kirschenhofer, Angela, Miriam Lenhard, Angela Kirschenhofer, Krocker, Katja, Burges, Alexander, Doris Mayr, Hertlein, Linda, Nagel, Dorothea, Petra Stieber   +19 more
core   +1 more source

Thirty-three long-term survivors after cytoreductive surgery in patients with peritoneal metastases from colorectal cancer: a retrospective descriptive study

World Journal of Surgical Oncology, 2021
Background Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in selected patients with peritoneal metastasis (PM) from colorectal cancer (CRC).
Yasuyuki Kamada, Koya Hida, Haruaki Ishibashi, Shouzou Sako, Akiyoshi Mizumoto, Masumi Ichinose, Naveen Padmanabhan, Shinya Yoshida, Yutaka Yonemura   +8 more
doaj   +1 more source

Malignant Mesothelioma [PDF]

Journal of the Royal Society of Medicine, 1989
Mesothelioma is a malignant tumour of the pleura or peritoneum caused by asbestos. It is increasing in frequency and the prognosis remains grim, with average survival around 1 year.Medical literature and personal experience.Amphibole fibres are far more potent than chrysotile in causing mesothelioma.A minority view suggests that mesotheliomas in those ...
openaire   +4 more sources