Results 61 to 70 of about 2,812,752 (406)

Malignancy within a tail gut cyst:a case of retrorectal carcinoid tumour [PDF]

, 2014
Purpose. Tailgut cysts with malignant transformation are rare entities. We discuss the diagnostic strategy and treatment of a malignancy within a tailgut cyst. Methods.
Abukar, A. A., Carey, F., Lim, C. B., Parcell, B. J., Patil, P. V., Ramsanahie, A., Steele, R. J. C., Thaha, M. A.   +7 more
core   +6 more sources

A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk. [PDF]

, 2020
BackgroundTumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single ...
Azizi, Armon, Bejnood, Alborz, Bouchard, Gina, Diehn, Maximilian, Feng, Weiguo, Forgó, Erna, Gentles, Andrew J, Hoang, Chuong D, Hui, Angela Bik-Yu, Jeong, Youngtae, Knowles, David A, Kuong, Amanda, Nair, Ramesh V, Nair, Viswam S, Plevritis, Sylvia K, van de Rijn, Matt, Varma, Sushama, West, Rob, Xu, Yue, Yu, Alice   +19 more
core   +4 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Patterns of lower risk myelodysplastic syndrome progression: factors predicting progression to high-risk myelodysplastic syndrome and acute myeloid leukemia

Haematologica
The patterns of low risk myelodysplastic syndrome (MDS) progression, and the clinical and molecular features of those patterns are not well described. We divided our low risk (LR) MDS patients (n=1914) into 4 cohorts: 1) Patients who remained LR-MDS (LR-
Akriti G. Jain, Somedeb Ball, Luis Aguirre, Najla Al Ali, David Kaldas, Sara Tinsley-Vance, Andrew Kuykendall, Onyee Chan, Kendra Sweet, Jeffrey E. Lancet, Eric Padron, David A. Sallman, Rami Komrokji   +12 more
doaj   +1 more source

Data: Is it Grey, Maligned or Malignant?

, 2015
Cancers, growths, past events, social issues, conditions, and trends are each proverbially described as on a spectrum from maligned to malignant and scientists, physicians, journalists, commentators, politicians and other specialists offer opinions and commentary on what frames the answer to this question of the title.
Gelfand, Julia, Tsang, Daniel
openaire   +2 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

A rare incidence of severe dermatological toxicities triggered by concomitant administration of all-trans retinoic acid and triazole antifungal in patients with acute promyelocytic leukemia: a case series and review of the literature

Journal of Medical Case Reports
Background All-trans retinoic acid (ATRA) is an indispensable part of the treatment of acute promyelocytic leukemia (APL). Although, mild cutaneous toxicities like mucocutaneous xerosis, rash, and pruritus are well reported, ATRA associated severe ...
Aisha Jamal, Rafia Hassam, Qurratulain Rizvi, Ali Saleem, Anum Khalid, Nida Anwar   +5 more
doaj   +1 more source

Cytological Study of Breast Lesions with Histopathological Correlation

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2021
Introduction: Breast disease is the most common and ranks first among malignant tumors affecting females in many parts of the world. Timely and accurate diagnosis of a breast lump is lifesaving.
Sarita Balasaheb Gore, D Birare Shivaji, B Narwade Sandhya, V Swami Dinesh   +3 more
doaj   +1 more source