Results 71 to 80 of about 2,705,450 (219)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Nodular melanoma: A case report

Pifu-xingbing zhenliaoxue zazhi
We report a case of nodular melanoma. A 46-year-old female presented with a brown papule on the medial side of the right upper arm for more than 40 years, with an increase in size for 2 months.
CHEN Hui, JIN Tianen, FANG Jingjing, LI Shangkun   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Breast Lesion Detection for Ultrasound Images Using MaskFormer

Sensors
This study evaluates the performance of the MaskFormer model for segmenting and classifying breast lesions using ultrasound images, addressing ultrasound’s limitations.
Aashna Anand, Seungho Jung, Sukhan Lee
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Endoscopic Endonasal Approach to Orbital Malignant Peripheral Nerve Sheath Tumor: A Minimally Invasive Method for Rare Orbital Tumor—Case Report and Review of Literature

Indian Journal of Neurosurgery
Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon tumors that rarely occur in the orbit. Malignant orbital tumors are always a challenge to remove completely.
Praveen M. Ganigi, Arijit Chakraborty, K.M. Bopanna, Sathwik R. Shetty   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Preoperative CT-based radiomics nomogram for progression-free survival prediction in pediatric posterior mediastinal malignancies

Frontiers in Oncology
BackgroundProgression-free survival (PFS) prediction plays a pivotal role in developing personalized treatment strategies and ensuring favorable long-term outcomes in pediatric posterior mediastinal malignant tumors.
Shucheng Bi, Chenghao Chen, Jie Yu, Ting Yang, Jihang Sun, Zunying Hu, Qi Zeng, Yun Peng   +7 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Differential diagnosis of breast mucinous carcinoma with an oval shape from fibroadenoma based on ultrasonographic features

BMC Women's Health
Background Approximately 50% of breast mucinous carcinomas (MCs) are oval and have the possibility of being misdiagnosed as fibroadenomas (FAs). We aimed to identify the key features that can help differentiate breast MC with an oval shape from FA on ...
Hongli Wang, Yue Hu, Cui Tan, Ran Gu, Yudong Li, Liang Jin, Xiaofang Jiang, Jingsi Mei, Qiang Liu, Chang Gong   +9 more
doaj   +1 more source