Results 71 to 80 of about 3,136,872 (312)

Reducing inequalities in care for patients with non-malignant diseases: Insights from a realist evaluation of an integrated palliative care pathway [PDF]

, 2016
Background: The need for palliative care is growing internationally with an increasing prevalence of non-malignant diseases. The integrated care pathway was implemented in primary care by multidisciplinary teams from 2009 in a locality in the North East
Lhussier, Monique, Jones, Diana, Dalkin, Sonia, Cunningham, William, Philipson, Pete   +4 more
core   +1 more source

Lenalidomide Exposure and TP53-Mutated Myelodysplastic Syndromes/Neoplasms

Current Oncology
The benefits of lenalidomide, which leverages TP53-dependent apoptosis and promotion of megakaryocytic differentiation, in lower-risk MDS (LR-MDS) with del(5q) are well-established and drive its frequent use in clinical practice. In parallel, advances in
Bahga Katamesh, Rory M. Shallis
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

IDH mutations are enriched in myelodysplastic syndrome patients with severe neutropenia and can be a potential for targeted therapy

Haematologica, 2022
Rami Komrokji, Najla al Ali, Onyee Chan, Kendra Sweet, Andrew Kuykendall, Jeffrey Lancet, Eric Padron, David A. Sallman   +7 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults [PDF]

, 2012
The objective of this review is to estimate the accuracy of the conventional oral examination (COE) used singly or in combination with another index test (Additional Table 1) as a screening test for the detection of oral cancer and potentially malignant ...
Liu, JLY, Lingen, Mark, Joseph LY Liu, Tanya Walsh, Ogden, Graham; id_orcid, Warnakulasuriya, Saman, Scully, C., Alexander R Kerr, Scully, Crispian, Glenny, Anne Marie; id_orcid, Ogden, Graham, Kerr, Alexander R., Glenny, Anne-Marie, Crispian Scully, Liu, Joseph L. Y., Ogden, G, Kerr, R, Lingen, M, Liu, Joseph L Y, Graham Ogden, Walsh, Tanya; id_orcid, Walsh, Tanya, Glenny, AM, Warnakulasuriya, S, Paul Brocklehurst, Mark Lingen, Brocklehurst, Paul, Brocklehurst, P, Saman Warnakulasuriya, Walsh, T   +29 more
core   +1 more source

P727: REFINING RISK STRATIFICATION IN CHRONIC MYELOMONOCYTIC LEUKEMIA (CMML): A COMPREHENSIVE ASSESSMENT OF THE IPSS-M AND OTHER MOLECULARLY INTEGRATED PROGNOSTIC MODELS

HemaSphere, 2023
Luis E. Aguirre, Akriti Jain, Somedeb Ball, Najla Al Ali, David Sallman, Andrew Kuykendall, Onyee Chan, Zhuoer Xie, Alison Walker, Kendra Sweet, Jeffrey Lancet, Eric Padron, Rami S. Komrokji   +12 more
doaj   +1 more source

Single-cell analysis reveals transcriptomic features and therapeutic targets in primary pulmonary lymphoepithelioma-like carcinoma

Communications Biology
Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of non-small-cell lung cancer. Duo to the current lack of precise targeted therapies, there is an urgent need to identify novel therapeutic targets.
Binghua Tan, Ke Xu, Yingcheng Lyu, Yicheng Liang, Ruihao Liang, Kai Lei, Jialu Liang, Jing Huang, Kefeng Wang, Duoguang Wu, Wenjian Wang, Xueting Hu, Kexi Wang, Minghui Wang, Huayue Lin   +14 more
doaj   +1 more source

MECOM-Rearranged Acute Myeloid Leukemia: Pathobiology and Management Strategies

Hematology Reports
Acute myeloid leukemia (AML) is an aggressive clonal hematopoietic malignancy, characterized by marked biological heterogeneity and variable clinical outcomes. Among its rarer genetic subsets is AML with rearrangements of the MDS1 and EVI1 complex locus (
Utsav Joshi, Rory M. Shallis
doaj   +1 more source