Results 81 to 90 of about 3,136,872 (312)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Laser augmented by brachytherapy versus laser alone in the palliation of adenocarcinoma of the oesophagus and cardia: a randomised study [PDF]

, 2002
Background: Many patients with advanced malignant dysphagia are not suitable for definitive treatment. The best option for palliation of dysphagia varies between patients. This paper looks at a simple technique for enhancing laser recanalisation.
Lovat, L.B., Blackman, G.M., Solano, J., Thorpe, S.M., Bown, S.G., Tobias, J.S., Spencer, G.M.   +6 more
core  

Mechanistic overview and suggested strategies to overcome BCL-2 inhibitor resistance in TP53-mutated acute myeloid leukemia

Frontiers in Cell and Developmental Biology
Venetoclax is a selective BCL-2 inhibitor that has transformed the treatment landscape for elderly and unfit patients with acute myeloid leukemia (AML).
Umar Iqbal, Rory M. Shallis
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]

, 2011
Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone, Friedrich W. Kreth, Hans A Kretzschmar, Lutz Juergen, Ludwig C. Hinske, Friedrich W Kreth, Ledderose Carola, Kretzschmar, Hans A., Kreth, Friedrich-Wilhelm, Juergen Lutz, Eigenbrod, Sabina, Kreth, Simone, Tonn, Joerg C., Thon Niklas, Thon, Niklas, Eigenbrod Sabina, Joerg C Tonn, Hinske, Ludwig C., Egensperger Rupert, Kretzschmar Hans A., Carola Ledderose, Rupert Egensperger, Kreth Friedrich W., Joerg C. Tonn, Lutz, Juergen, Niklas Thon, Hans A. Kretzschmar, Kreth, Friedrich W., Egensperger, Rupert, Hinske Ludwig C., Hinske, Ludwig Christian, Ludwig C Hinske, Sabina Eigenbrod, Tonn Joerg C., Ledderose, Carola, Simone Kreth   +35 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1

Journal of Experimental & Clinical Cancer Research
Background Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal tumor and has become an important global health problem. The PI3K/AKT signaling pathway plays a key role in the development of ESCC.
Kai Lei, Ruihao Liang, Jialu Liang, Nan Lu, Jing Huang, Ke Xu, Binghua Tan, Kexi Wang, Yicheng Liang, Wenjian Wang, Huayue Lin, Minghui Wang   +11 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas [PDF]

, 2010
Background: New drugs are constantly sought after to improve the survival of patients with malignant gliomas. The ideal substance would selectively target tumor cells without eliciting toxic side effects.
Senft, Christian, Priester, Maike, Kögel, Donat, Seifert Volker, Weissenberger Jakob, Donat Kögel, Senft Christian, Polacin, Margareth, Margareth Polacin, Christian Senft, Maike Priester, Seifert, Volker, Polacin Margareth, Volker Seifert, Jakob Weissenberger, Priester Maike, Kögel Donat, Weissenberger, Jakob   +17 more
core   +2 more sources

Clinical Significance of Fine Needle Aspiration in Managing Patients with Breast Lesions

Folia Medica, 2018
Background: Fine needle aspiration cytology (FNAC) has been and still is challenged about its role in the management of breast lesions. Guidelines today mandate that breast lesions should be managed with a triple assessment system consisting of clinical,
Dinas Konstantinos, Pratilas Georgios C., Nasioutziki Maria, Vavoulidis Eleftherios, Makris Vasileios, Loufopoulos Panagiotis D., Kalder Matthias   +6 more
doaj   +1 more source