Results 91 to 100 of about 3,136,872 (312)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Phase 1 study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers [PDF]

, 2004
We assessed the safety, tolerability and efficacy of the immunomodulatory drug, CC-5013 (REVIMID(TM)), in the treatment of patients with metastatic malignant melanoma and other advanced cancers.
Muller, G.W., Dredge, K., Clarke, IA, Kristeleit, H., Dredge, K, D I Stirling, A G Dalgleish, Zeldis, J., S Nicholson, Polychronis, A., Kristeleit, H, G W Muller, H Kristeleit, J B Bartlett, Nicholson, S, K Dredge, Stirling, D.I., Michael, A, Dalgleish, A.G., Polychronis, A, Muller, GW, Pandha, H,, Stirling, DI, I A Clarke, Clarke, I.A., Bartlett, JB, Zeldis, J, Nicholson, S., H Pandha, Dalgleish, AG, J Zeldis, Pandha, H, A Polychronis, Michael, A., A Michael, Bartlett, J.B.   +35 more
core   +1 more source

Malignant myoepithelioma arising from pleomorphic adenoma of the soft palate

, 2007
Malign Myoepitelyomalar tüm tükrük bezi malignitelerinin %1`inden azını oluştururlar. Malign Myoepitelyoma genellikle parotis bezinden kaynaklanır ancak minör tükrük bezlerinin bulunduğu bölgelerde de görülebilir.
Yardımcı, Sumru, Selçuk, Ömertarık, Kurukahvecioğlu, Malignant, Öztürk, Emine   +3 more
core   +1 more source

Menin Inhibition in Acute Myeloid Leukemia: Pathobiology, Progress and Promise

Biomedicines
Acute myeloid leukemia (AML) is a highly aggressive malignancy defined by significant biological diversity and variable patient outcomes. A key subset of AML is driven by abnormalities that lead to the overexpression of the oncogenic transcription ...
Utsav Joshi, Rory M. Shallis
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Clinico-statistical Study of Malignant Tumors in Oral and Maxillofacial Regions [PDF]

, 1995
P(論文)Clinico-statistical observations were made of 48 cases of malignant tumors of the oral and maxillofacial regions from 1978 to 1995 at the Department of Oral Surgery, School of Dentistry, Health Sciences University of Hokkaido.
金澤, 正昭, 賀来, 亨, 24518, 柴田, 敏之, 窪田, 正樹, 平, 博彦, 34385, 34384, 武藤, 壽孝, 34383, 34382, 34381, 34391, 34390, 村瀬, 博文, 北所, 弘行, 有末, 眞, 34389, 34388, 道谷, 弘之, 34387, 34386, 奥村, 一彦, 安彦, 善裕   +23 more
core  

Comparative Genomic Hybridization of Human Malignant Gliomas Reveals Multiple Amplification Sites and Nonrandom Chromosomal Gains and Losses [PDF]

, 1994
Nine human malignant gliomas (2 astrocytomas grade III and 7 glioblastomas) were analyzed using comparative genomic hybridization (CGH). In addition to the amplification of the EGFR gene at 7p12 in 4 of 9 cases, six new amplification sites were mapped to
Vogel, S., Ried, Thomas, Thiel, G., Manoir, Stanislas du, Meffert, M. C., Speicher, Michael R., Cremer, Thomas, Donis-Keller, Helen, Nürnberg, P., Lozonova, T., Jauch, Anna, Schröck, Evelin, Witkowski, R., Jänisch, W.   +13 more
core   +1 more source

Assessing the role of venetoclax in combination with hypomethylating agents in higher risk myelodysplastic syndrome

Blood Cancer Journal, 2022
Rami S. Komrokji, Avani M. Singh, Najla Al Ali, Onyee Chan, Eric Padron, Kendra Sweet, Andrew Kuykendall, Jeffrey E. Lancet, David A. Sallman   +8 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Chromosome 17 Candidate Gene Analysis in a Population Referred Because of Suspected Susceptibility to Malignant Hyperthermia

Malignant hyperthermia susceptibility (MHS) is an autosomal dominant disorder of muscle metabolism that is triggered by potent inhalational anesthetics and depolarizing muscle relaxants.
Olckers, Antonel, Jedlicka, Anne E., Rosenberg, Henry, Heiman-Patterson, Terry, Levitt, Roy C., Fletcher, Jeffery E., George, Alfred L., Vita, Gary M.   +7 more
core   +1 more source