Results 81 to 90 of about 395,984 (223)

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Morbidity and Mortality of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients Aged 70 Years and Older: A Two‐Center 10‐Year Experience

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is established for peritoneal surface malignancies, but its use in older patients is debated. We assessed CRS‐HIPEC morbidity and mortality in patients aged ≥ 70 years using a cohort of younger patients as a comparator.
Ali Ediz Kıvanç, Mehmet Oduncu, Pırıltı Özcan, Özgül Düzgün, Neşet Köksal   +4 more
wiley   +1 more source

Current Use, Monitoring and Reversal of Neuromuscular Block in Pediatric Anesthesia and Intensive Care: A Web‐Based Cross‐Sectional ESAIC Survey

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Neuromuscular blocking agents are recommended by the European Society of Anaesthesiology and Intensive Care (ESAIC) and European Society of Paediatric Anaesthesia (ESPA) for facilitating tracheal intubation in children. Despite these recommendations, real‐world data on how neuromuscular blocking agents are used, monitored, and ...
Giulia Bonatti, Mirjana Gander, Arash Afshari, Francis Veyckemans, Thomas Fuchs‐Buder, Thomas Riva, Markus Huber, Nicola Disma, Alexander Fuchs   +8 more
wiley   +1 more source

A Case Report of Suspected Malignant Hyperthermia: How Will the Diagnosis Affect a Patient’s Insurability?

Case Reports in Anesthesiology, 2018
The purpose of this case report is to increase awareness that a diagnosis of malignant hyperthermia may have long-lasting or permanent effects on a patient’s insurance eligibility or premiums despite legislation providing varying levels of protection ...
Brian M. Osman, Isabela C. Saba, William A. Watson   +2 more
doaj   +1 more source

Hipertemia maligna: revisão da literatura e relato de caso. [PDF]

, 1998
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Cirúrgica, Curso de Medicina, Florianópolis ...
Coral, Volnei
core  

A Biomimetic Breast Tumor‐On‐Chip Platform Reveals Mesenchymal Marker Upregulation Following Gold Nanorod Photothermal Therapy

Small, EarlyView.
A biomimetic microfluidic tumor‐on‐chip platform was designed to uncover subtype‐dependent responses to nanoparticle‐mediated photothermal therapy in breast cancer spheroids. The platform establishes a physiologically relevant and controllable 3D system for precision evaluation of nanophotothermal cancer therapies.
Camila A. Salvego, Hasti Honari, Anastasiia Dubrova, Stéphanie Descroix, Martha S. Ribeiro, Aurore V. Walle, Claire Wilhelm   +6 more
wiley   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Efficacy of Radiofrequency Hyperthermia Combined with Chemotherapy 
in Treatment of Malignant Pericardial Effusion Caused by Lung Cancer

Chinese Journal of Lung Cancer, 2011
Background and objective Malignant pericardial effusion is one of the serious complications of lung cancer and lack effective treatment methods. The aim of this study is to evaluate the efficacy and safety of radiofrequency hyperthermia combined with ...
Pengfei LUO, Peiguo CAO, Zhiping YAO
doaj   +1 more source

Functional Repurposing of Magnetic Nanoparticle‐Assisted Hyperthermia for Immune Cell Labelling and Tracking

Small Methods, EarlyView.
We propose mild‐MHT protocol for the quick internalization of magnetic nanoparticles (MNPs) by immune cells. The heat induced by MNPs under alternating magnetic field stimulate MNPs diffusion and cell membrane invagination, accelerating the cellular internalization of MNPs. ABSTRACT Immune cell therapies show promise in hematologic malignancies and are
Giulia E. P. Nucci, Chiara Vitale, Alessandro di Girolamo, Niccolò Silvestri, Stefano Persano, Lorenci Gjurgjaj, Cristina Bottino, Roberta Castriconi, Teresa Pellegrino   +8 more
wiley   +1 more source

Caution for psychiatrists: malignant hyperthermia risks with the anesthetic agent succinylcholine (Suxamethonium) during electroconvulsive therapy

BMC Psychiatry
Background Malignant hyperthermia is a potentially lethal condition triggered by specific anesthetic drugs, especially a depolarizing muscle relaxant of succinylcholine (Suxamethonium).
Masaki Nakano, Michitaka Funayama, Taketo Takata, Riko Wakisaka, Genki Koyama, Akihiro Koreki, Takuto Ishida, Hiroyuki Uchida, Masaru Mimura   +8 more
doaj   +1 more source