Results 1 to 10 of about 6,108 (207)

Dantrolene use across surgical and medical care at Mayo Clinic from 2010 to 2024: Indications, frequency, and value for identifying malignant hyperthermia [PDF]

Biomolecules & Biomedicine
Dantrolene is the definitive treatment for malignant hyperthermia (MH), a rare and life-threatening disorder. This retrospective study aimed to achieve two objectives: (1) to characterize the indications and frequency of dantrolene administration in ...
David Cho, Toby N. Weingarten, Juraj Sprung, Aurelia Zodl, Martin J. Ryll, Tracy E. Harrison   +5 more
doaj   +2 more sources

Intranasal dantrolene nanoparticles inhibit lipopolysaccharide-induced depression and anxiety behavior in mice [PDF]

Translational Psychiatry
This study investigates the therapeutic effectiveness of intranasal dantrolene nanoparticle pretreatment to inhibit lipopolysaccharide (LPS)-induced pathological inflammation, synapse destruction, and depressive and anxiety behavior in mice.
Jia Liu, Yan Lu, Piplu Bhuiyan, Jacob Gruttner, Lauren St. Louis, Yutong Yi, Ge Liang, Huafeng Wei   +7 more
doaj   +2 more sources

The Effectiveness of a Mobile National Remote Emergency System for Malignant Hyperthermia in China: Retrospective Pre-Post Implementation Study [PDF]

Journal of Medical Internet Research
BackgroundMalignant hyperthermia (MH) seriously threatens perioperative safety. Historically, limited awareness of MH among anesthesiologists and the unavailability of dantrolene have caused a high mortality rate of MH events in China.
Lingcan Tan, Hong Yu, Yunxia Zuo, Bin Liu, Tao Zhu, Xiaoqian Deng   +5 more
doaj   +2 more sources

Dantrolene-Responsive Muscle Stiffness in a Patient With a Normal Neurologic Exam and EMG: A Case Report [PDF]

Case Reports in Neurological Medicine
Muscle stiffness or rigidity is a common problem yet is addressed in few studies. Patients with muscle rigidity/spasticity due to injury of upper motor neurons or genetic muscle diseases are sometimes treated with dantrolene.
Adam S. Deardorff, Matthew J. Burford, Mark M. Rich   +2 more
doaj   +2 more sources

Successful management of malignant hyperthermia without dantrolene: A case report [PDF]

Journal of International Medical Research
Malignant hyperthermia during surgery represents a significant challenge for anesthesiologists due to its high mortality rate and the risk of long-term physiological damage.
Cailing Zhang, Huanbin Wang, Zhi Chen, Yuennong Zhang   +3 more
doaj   +2 more sources

Malignant hyperthermia crisis during scoliosis surgery in a pediatric cerebral palsy patient: a case of early recognition and successful intervention [PDF]

Frontiers in Pediatrics
BackgroundMalignant hyperthermia (MH) is a rare but life-threatening complication of general anesthesia, characterized by a hypermetabolic response that can lead to severe complications if not managed promptly. Patients with neuromuscular disorders, such
Saleh M. Kardm, Abdulmonem Alsiddiky, Asim J. Alamri, Ravi Shankar Reddy   +3 more
doaj   +2 more sources

Pharmacokinetics of Dantrolene in the Plasma Exchange Treatment of Malignant Hyperthermia in a 14-Year-Old Chinese Boy: A Case Report and Literature Review

Frontiers in Medicine, 2022
Malignant hyperthermia (MH) is a rare life-threatening response that is triggered by exposure to specific anesthetics commonly used during surgical interventions. Dantrolene is a well-known drug used as the first-line therapy for MH.
Xiaoxiao Li, Xiaoxiao Li, Chao Li, Yang Zhou, Yang Zhou, Zhengqian Li, Zhengqian Li, Xin Xiong, Chuhui Wang, Chuhui Wang, Congya Zhou, Congya Zhou, Bin Han, Li Yang, Xiangyang Guo, Xiangyang Guo   +15 more
doaj   +1 more source

Intravenous dantrolene in hypermetabolic syndromes: a survey of the U.S. Veterans Health Administration database

BMC Anesthesiology, 2022
Background Intravenous dantrolene is often prescribed for hypermetabolic syndromes other than the approved indication of malignant hyperthermia (MH). To clarify the extent of and indications for dantrolene use in conditions other than MH, we sought to ...
Stanley N. Caroff, Christopher B. Roberts, Henry Rosenberg, Joseph R. Tobin, Stacey Watt, Darlene Mashman, Sheila Riazi, Rosalind M. Berkowitz   +7 more
doaj   +1 more source

Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model. [PDF]

PLoS ONE, 2018
The ryanodine receptor antagonist dantrolene inhibits calcium release from the sarcoplasmic reticulum and reduces cardiac ischaemia-reperfusion injury (IRI) in global warm ischaemia models however the cardioprotective potential of dantrolene under ...
Jeanette E Villanueva, Ling Gao, Hong C Chew, Mark Hicks, Aoife Doyle, Min Ru Qui, Kumud K Dhital, Peter S Macdonald, Andrew Jabbour   +8 more
doaj   +1 more source

Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress

Biochemistry and Biophysics Reports, 2020
Introduction: Our previous studies demonstrated that dantrolene, a ryanodine receptor stabilizer, prevents endoplasmic reticulum (ER) stress in the heart.
Masaki Tamitani, Takeshi Yamamoto, Naoki Yamamoto, Koichi Fujisawa, Shinji Tanaka, Yoshihide Nakamura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Taro Takami, Shigeki Kobayashi, Isao Sakaida, Masafumi Yano   +12 more
doaj   +1 more source