Results 1 to 10 of about 325 (107)
Frontiers in Medicine, 2022 Malignant hyperthermia (MH) is a rare life-threatening response that is triggered by exposure to specific anesthetics commonly used during surgical interventions. Dantrolene is a well-known drug used as the first-line therapy for MH.
Xiaoxiao Li +15 more
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Functional recovery after dantrolene-supplementation of cold stored hearts using an ex vivo isolated working rat heart model. [PDF]
PLoS ONE, 2018 The ryanodine receptor antagonist dantrolene inhibits calcium release from the sarcoplasmic reticulum and reduces cardiac ischaemia-reperfusion injury (IRI) in global warm ischaemia models however the cardioprotective potential of dantrolene under ...
Jeanette E Villanueva +8 more
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BMC Anesthesiology, 2022 Background Intravenous dantrolene is often prescribed for hypermetabolic syndromes other than the approved indication of malignant hyperthermia (MH). To clarify the extent of and indications for dantrolene use in conditions other than MH, we sought to ...
Stanley N. Caroff +7 more
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Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca2+ level and ER stress
Biochemistry and Biophysics Reports, 2020 Introduction: Our previous studies demonstrated that dantrolene, a ryanodine receptor stabilizer, prevents endoplasmic reticulum (ER) stress in the heart.
Masaki Tamitani +12 more
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The Possible Protective Role of Verapamil and Dantrolene in Experimentally Induced Early Acute Pancreatitis in Male Albino Rat [PDF]
The Egyptian Journal of Histology, 2023 Introduction: The aim of the present work was to elucidate the possible protective role of Verapamil (VPM) and Dantrolene (Da) in controlling experimentally induced early acute pancreatitis (AP) in male albino rats.Materials and Methods: Thirty- two ...
Ahmed Taha +4 more
doaj +1 more source
Frontiers in Physiology, 2021 Ryanodine receptors (RyRs), the intracellular Ca2+ release channels, are expressed in T lymphocytes and other types of immune cells. Modulation of RyRs has been shown to affect T cell functions in vitro and immune responses in vivo.
Natalia C. Osipchuk +3 more
doaj +1 more source
Intranasal administration of dantrolene increased brain concentration and duration.
PLoS ONE, 2020 Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang +7 more
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Scientific Reports, 2021 Diabetics have a higher risk of developing cerebral vasospasms (CVSP) after subarachnoid hemorrhagic stroke than non-diabetics. Serotonin (5-HT) is one of the key vasoconstrictors released in the hemorrhagic blood and an important contributor to the ...
Marie Román +3 more
doaj +1 more source
Heart Rhythm O2, 2020 Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and ...
Colleen Nofi, DO +7 more
doaj +1 more source
The effect of long-term oral dantrolene on the neuromuscular action of rocuronium: a case report [PDF]
Korean Journal of Anesthesiology, 2014 Oral dantrolene causes a dose-dependent depression of skeletal muscle contractility. A 52-year-old man treated with oral dantrolene for spasticity after spinal cord injury was scheduled to undergo irrigation and drainage of a thigh abscess under general ...
Jinwoo Jeon +4 more
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