Successful management of malignant hyperthermia without dantrolene: A case report [PDF]
Journal of International Medical ResearchMalignant hyperthermia during surgery represents a significant challenge for anesthesiologists due to its high mortality rate and the risk of long-term physiological damage.
Cailing Zhang +3 more
doaj +3 more sources
Dantrolene use across surgical and medical care at Mayo Clinic from 2010 to 2024: Indications, frequency, and value for identifying malignant hyperthermia [PDF]
Biomolecules & BiomedicineDantrolene is the definitive treatment for malignant hyperthermia (MH), a rare and life-threatening disorder. This retrospective study aimed to achieve two objectives: (1) to characterize the indications and frequency of dantrolene administration in ...
David Cho +5 more
doaj +2 more sources
Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models [PDF]
Molecular Therapy: Nucleic Acids, 2019 Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models.
Florian Barthélémy +6 more
doaj +3 more sources
Intranasal dantrolene nanoparticles inhibit lipopolysaccharide-induced depression and anxiety behavior in mice [PDF]
Translational PsychiatryThis study investigates the therapeutic effectiveness of intranasal dantrolene nanoparticle pretreatment to inhibit lipopolysaccharide (LPS)-induced pathological inflammation, synapse destruction, and depressive and anxiety behavior in mice.
Jia Liu +7 more
doaj +2 more sources
Intranasal administration of dantrolene increased brain concentration and duration.
PLoS ONE, 2020 Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang +7 more
doaj +3 more sources
Dantrolene-Responsive Muscle Stiffness in a Patient With a Normal Neurologic Exam and EMG: A Case Report [PDF]
Case Reports in Neurological MedicineMuscle stiffness or rigidity is a common problem yet is addressed in few studies. Patients with muscle rigidity/spasticity due to injury of upper motor neurons or genetic muscle diseases are sometimes treated with dantrolene.
Adam S. Deardorff +2 more
doaj +2 more sources
Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices. [PDF]
J PhysiolAbstract figure legend ent‐Vert selectively inhibits RyR2‐mediated sarcoplasmic reticulum (SR) Ca2+ leak and prevents triggered activity in human cardiac slices. A, in human ventricular slices exposed to β‐adrenergic stimulation with Iso and RyR2 sensitization with caffeine, RyR2 channels become hyperactive, leading to Ca2+ sarcoplasmic leak and ...
Madrid MK +6 more
europepmc +2 more sources
Journal of Medical Internet ResearchBackgroundMalignant hyperthermia (MH) seriously threatens perioperative safety. Historically, limited awareness of MH among anesthesiologists and the unavailability of dantrolene have caused a high mortality rate of MH events in China.
Lingcan Tan +5 more
doaj +2 more sources
Malignant hyperthermia crisis during scoliosis surgery in a pediatric cerebral palsy patient: a case of early recognition and successful intervention [PDF]
Frontiers in PediatricsBackgroundMalignant hyperthermia (MH) is a rare but life-threatening complication of general anesthesia, characterized by a hypermetabolic response that can lead to severe complications if not managed promptly. Patients with neuromuscular disorders, such
Saleh M. Kardm +3 more
doaj +2 more sources
Effects of Dantrolene on Steps of Excitation-Contraction Coupling in Mammalian Skeletal Muscle Fibers [PDF]
, 2017 Collet, Claude +7 more
core +3 more sources