Results 31 to 40 of about 6,108 (207)

Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy

Case Reports in Anesthesiology, 2020
Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management ...
Warangkana Lapisatepun, Supawan Arkarattanakul   +1 more
doaj   +1 more source

Malignant hyperthermia in a regional facility: A case study

Journal of Perioperative Nursing, 2020
Malignant hyperthermia (MH) is a rare hypermetabolic state that may be triggered by both anaesthesia and non-anaesthesia triggers. The main anaesthesia triggers for MH are the depolarising muscle relaxant suxamethonium and volatile anaesthetic gases. MH
Catherine Kleidon
doaj   +1 more source

Effect of dantrolene on rat brain tryptophan hydroxylase [PDF]

, 1988
Recently, dantrolene has been applied to the treatment of neuroleptic malignant syndrome. In some treated patients, dramatic changes in the electroencephalogram and in the levels of monoamine metabolites in cerebrospinal fluid were observed. Nonetheless,
Shoshiro OKADA, Okada, Shoshiro
core   +1 more source

Pharyngeal spasticity due to dantrolene

, 2014
What is known and objective: Dantrolene can be combined with baclofen to better treat spasticity, but may cause muscular weakness and dysphagia. We instead describe a pharyngeal spasm due to dantrolene.
F. Locatelli, S. Strazzer, M. Pozzi, P. Avantaggiato, S. Galbiati, M. Lanfranchi, L. Tufarulo, G. Rizzi, S. Radice, E. Clementi, V. Amorelli   +10 more
core   +1 more source

Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias

, 2020
Aims In atrial fibrillation (AF), an increased diastolic Ca2+ leak from the sarcoplasmic reticulum (SR) mediated by calcium/calmodulin-dependent-protein-kinaseIIdC (CaMKII) can serve as a substrate for arrhythmia induction and persistence. Dantrolene has
Rupprecht, Leopold, Lebek, Simon, Neef, Stefan, Wagner, Stefan, Maier, Lars S., Stehle, Thea, Mustroph, Julian, Dybkova, Nataliya, Sossalla, Samuel, Pabel, Steffen, Keyser, Andreas, Maier, Lars S   +11 more
core   +1 more source

Effect of dantrolene on calcium transients.

, 2014
A) Depolarization with 60 mM KCl and 20 mM caffeine in normal buffer, followed by exposure to sequential exposures to caffeine in the presence of 10 µM dantrolene. B) The amplitude of the caffeine transient in the absence or presence of dantrolene.
Pilar Martin-Duque (620116), Georges Vassaux (329006), Marta Fernandez-Fuente (255181), Richard J. Piercy (102272), Cesare M. Terracciano (620115), Susan C. Brown (358374)   +5 more
core   +1 more source

Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models

Molecular Therapy: Nucleic Acids, 2019
Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models.
Florian Barthélémy, Richard T. Wang, Christopher Hsu, Emilie D. Douine, Eugene E. Marcantonio, Stanley F. Nelson, M. Carrie Miceli   +6 more
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina [PDF]

Arquivos de Neuro-Psiquiatria, 1998
A síndrome neuroléptica maligna (SNM) consiste em reação idiossincrática a neurolépticos, provavelmente relacionada a bloqueio dos receptores dopaminérgicos nos gânglios da base, sendo por isso também conhecida como síndrome da deficiência aguda de ...
RICARDO A. HANEL, MARCOS C. SANDMANN, MARTINA KRANICH, PAULO R. M. DE BITTENCOURT   +3 more
doaj   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source