Results 31 to 40 of about 4,800 (169)

Dantrolene enhances the protective effect of hypothermia on cerebral cortex neurons

Neural Regeneration Research, 2015
Therapeutic hypothermia is the most promising non-pharmacological neuroprotective strategy against ischemic injury. However, shivering is the most common adverse reaction. Many studies have shown that dantrolene is neuroprotective in in vitro and in vivo
Sui-yi Xu, Feng-yun Hu, Li-jie Ren, Lei Chen, Zhu-qing Zhou, Xie-jun Zhang, Wei-ping Li   +6 more
doaj   +1 more source

A case of malignant hyperthermia during anesthesia induction with sevoflurane -A case report- [PDF]

Korean Journal of Anesthesiology, 2010
We experienced a case of malignant hyperthermia (MH) in 6-year-old boy during anesthesia induction for strabismus surgery. It has been generally reported that sevoflurane can induce the delayed onset of MH in the absence of succinylcholine.
Yoon Sook Lee, Woon Young Kim, Se Hwa Lee, Sung Moon Baek, Se Jin Ok, Jae Hwan Kim, Young Cheol Park   +6 more
doaj   +1 more source

Repurposing Dantrolene for Long-Term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx Mouse

Molecular Therapy: Nucleic Acids, 2018
Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, which is essential to muscle health. DMD “exon skipping” uses anti-sense oligo-nucleotides (AONs) to force specific exon exclusion during mRNA processing to
Derek W. Wang, Ekaterina I. Mokhonova, Genevieve C. Kendall, Diana Becerra, Yalda B. Naeini, Rita M. Cantor, Melissa J. Spencer, Stanley F. Nelson, M. Carrie Miceli   +8 more
doaj   +1 more source

Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.

PLoS ONE, 2015
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal calcium release from ...
Kirsi Penttinen, Heikki Swan, Sari Vanninen, Jere Paavola, Annukka M Lahtinen, Kimmo Kontula, Katriina Aalto-Setälä   +6 more
doaj   +1 more source

Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy

Case Reports in Anesthesiology, 2020
Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management ...
Warangkana Lapisatepun, Supawan Arkarattanakul   +1 more
doaj   +1 more source

Malignant hyperthermia in a regional facility: A case study

Journal of Perioperative Nursing, 2020
Malignant hyperthermia (MH) is a rare hypermetabolic state that may be triggered by both anaesthesia and non-anaesthesia triggers. The main anaesthesia triggers for MH are the depolarising muscle relaxant suxamethonium and volatile anaesthetic gases. MH
Catherine Kleidon
doaj   +1 more source

Síndrome neuroléptica maligna: relato de caso com recorrência associada ao uso de olanzapina [PDF]

Arquivos de Neuro-Psiquiatria, 1998
A síndrome neuroléptica maligna (SNM) consiste em reação idiossincrática a neurolépticos, provavelmente relacionada a bloqueio dos receptores dopaminérgicos nos gânglios da base, sendo por isso também conhecida como síndrome da deficiência aguda de ...
RICARDO A. HANEL, MARCOS C. SANDMANN, MARTINA KRANICH, PAULO R. M. DE BITTENCOURT   +3 more
doaj   +1 more source

Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models

Molecular Therapy: Nucleic Acids, 2019
Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models.
Florian Barthélémy, Richard T. Wang, Christopher Hsu, Emilie D. Douine, Eugene E. Marcantonio, Stanley F. Nelson, M. Carrie Miceli   +6 more
doaj   +1 more source

Malignant hyperthermia in children [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2008
INTRODUCTION Malignant hyperthermia is a rare disease which is mainly an inherited autosomal dominant trait. It is characteristic for muscle rigidity, metabolism or respiratory acidosis, high values of serum creatine kinase.
Igrutinović Zoran, Vuletić Biljana, Vujić Ana, Marković Slavica, Kostić Gordana   +4 more
doaj   +1 more source

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source