Results 41 to 50 of about 6,108 (207)
The epigenetic landscape of skeletal muscle in response to exercise and aging
The FEBS Journal, EarlyView.Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley +1 more source
, 2016 Dantrolene is the only available drug for the treatment of malignant hyperthermia, a life-threatening inborn sensitivity of the ryanodine receptor (RyR1) in skeletal muscles to volatile anesthetics.
Burckhardt, Gerhard +3 more
core +1 more source
International Journal of Endocrinology, 2018 Diabetics have a higher risk of developing cerebral vasospasms (CVSP) than nondiabetics. The addition of the ryanodine receptor (RyR) blocker dantrolene to standard therapies reduces vasospasms in nondiabetics.
Maria J. Crespo +5 more
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Caffeine and dobutamine challenge induces bidirectional ventricular tachycardia in normal rats
Heart Rhythm O2, 2020 Background: Bidirectional ventricular tachycardia (BD-VT) is an intriguing arrhythmia, characterized by a beat-to-beat alternation of the QRS polarity on electrocardiogram. Currently there is no simple BD-VT animal model.
Chenyu Zhang, BS, Youhua Zhang, MD, PhD
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The Journal of Physiology, EarlyView.Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi +11 more
wiley +1 more source
Malignant hyperthermia in children [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2008 INTRODUCTION Malignant hyperthermia is a rare disease which is mainly an inherited autosomal dominant trait. It is characteristic for muscle rigidity, metabolism or respiratory acidosis, high values of serum creatine kinase.
Igrutinović Zoran +4 more
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Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve +11 more
wiley +1 more source
Dantrolene : From Malignant Hyperthermia to Alzheimer’s Disease
, 2020 Dantrolene, a ryanodine receptor antagonist, is primarily known as the only clinically acceptable and effective treatment for Malignant Hyperthermia (MH).
Yun Shi, Huafeng Wei, Yong Wang
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Perioperative management of malignant hyperthermia during general anesthesia: A report of two cases
Clinical Case Reports, 2022 Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality.
Xiaowei Chi +5 more
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Journal of Multidisciplinary Healthcare, 2022 Lingcan Tan,1,* Yi Teng,1,* Hong Yu,1 Chunyuan Liu,2 Kun Xiao,3 Jin Yin,4 Yunxia Zuo,1 Tao Zhu,1 Xiaoqian Deng1 1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Department of ...
Tan L +8 more
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