Results 51 to 60 of about 1,955 (161)
A Case of Fatal Malignant Hyperthermia During Pes Equinovarus Surgery in a Child
Journal of Pediatric Emergency and Intensive Care Medicine, 2018 Malignant hyperthermia (MH) is a genetic syndrome characterized by hyperthermia, tachycardia, acidosis, and muscle rigidity, often triggered by depolarizing muscle relaxants such as volatile anesthetics and/or succinylcholine.
Ümüt Altuğ +5 more
doaj +1 more source
Management of spasticity in children with cerebral palsy
Acta Orthopaedica et Traumatologica Turcica, 2020 Management of spasticity is a major challenge to the rehabilitation team. The initial management has centered on the elimination of externally exacerbating causes, physical therapy, splinting and casting.
Dennis J. Matthews, Birol Balaban
doaj +1 more source
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, Volume 13, Issue 37, 3 July 2026.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
EFFECTS OF DANTROLENE ON ACETYLCHOLINE-INDUCED CONTRACTIONS OF ISOLATED MOUSE ILEUM
Eurasian Journal of Medicine, 2019 Effect of skeletal muscular relaxant, dantrolene, on isolated longitudinal smooth muscle of mouse ileum of which contractions were induced by 10-6 M of acetylcholine (ACh) was investigated. Studies were performed in Tyrode solution. The first ACh-induced
Fatma Göçer +4 more
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Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Dantrolene mediates vasorelaxation in cerebral vasoconstriction: a case series
, 2009 INTRODUCTION: Cerebral vasoconstriction syndromes such as vasospasm after subarachnoid hemorrhage (SAH) and trauma, or Call-Fleming syndrome are difficult to treat, and can lead to substantial disability and death.
Sims, John R. +3 more
core +1 more source
Translational PsychiatryThis study investigates the therapeutic effectiveness of intranasal dantrolene nanoparticle pretreatment to inhibit lipopolysaccharide (LPS)-induced pathological inflammation, synapse destruction, and depressive and anxiety behavior in mice.
Jia Liu +7 more
doaj +1 more source
Open Medicine, 2023 Malignant hyperthermia (MH) is an inherited skeletal muscle disorder caused primarily by a genetic mutation, usually in the calcium channel gene of the muscle. This mutation can lead to muscle hypersensitivity to volatile anesthetics (such as sevoflurane)
Lan Haiyan +6 more
doaj +1 more source
Malignant Hyperthermia in Sweden: Clinical Presentations and Genetic Findings
Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.ABSTRACT Introduction Malignant hyperthermia (MH) is a pharmacogenetic, hypermetabolic and potentially lethal reaction to potent volatile anaesthetics and the muscle relaxant succinylcholine. To improve the understanding of MH, the aim of this retrospective study was to describe the Swedish cohort with respect to clinical manifestations, demographics ...
Anna Hellblom +2 more
wiley +1 more source
MH Survival without Dantrolene
, 2020 Treatment of intraoperative malignant hyperthermia (MH) usually involves administration of IV dantrolene, which reduces the mortality from over 80% if untreated to less than 10%.1 When dantrolene is simply not available, physical and metabolic treatments
Ma, Zhengliang, MD +4 more
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