Results 71 to 80 of about 10,940 (260)

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Management of spasticity in children with cerebral palsy

Acta Orthopaedica et Traumatologica Turcica, 2020
Management of spasticity is a major challenge to the rehabilitation team. The initial management has centered on the elimination of externally exacerbating causes, physical therapy, splinting and casting.
Dennis J. Matthews, Birol Balaban
doaj   +1 more source

Reversible cerebral vasoconstriction syndrome: A narrative review

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1162-1180, May 2026.
Abstract Objectives/Background This review summarizes current insights into Reversible cerebral vasoconstriction syndrome (RCVS) diagnosis, management, and outcomes. RCVS is a cerebrovascular disorder characterized by recurrent thunderclap headaches and transient segmental vasoconstriction of cerebral arteries, typically resolving within 3 months ...
Ícaro Araújo de Sousa, Abner da Silva Machado, Arthur de Oliveira Veras, Thiago Oscar Goulart, Sarah Galassi Tatsuta, Trajano Aguiar Pires Gonçalves, Eva Rocha, Octávio Marques Pontes‐Neto   +7 more
wiley   +1 more source

EFFECTS OF DANTROLENE ON ACETYLCHOLINE-INDUCED CONTRACTIONS OF ISOLATED MOUSE ILEUM

Eurasian Journal of Medicine, 2019
Effect of skeletal muscular relaxant, dantrolene, on isolated longitudinal smooth muscle of mouse ileum of which contractions were induced by 10-6 M of acetylcholine (ACh) was investigated. Studies were performed in Tyrode solution. The first ACh-induced
Fatma Göçer, M. Emin Büyükokuroğlu, Nazım Doğan, Nur Babaoğlu, Akçahan Geptiremen   +4 more
doaj  

Conformational Studies of Ortho- and Meto-Isomers and Methyl, Dimethyl, and Chloro Ortho-Substituted Analogues of Dantrolene Using Ab Initio SCF-MO Procedures [PDF]

, 1995
The conformation of the nitro group of nitroaromatic compounds relative to the aromatic ringsystem is suggested to affect their metabolic activation and mutagenicity. We have recently showed the nitrophenylfuran skeletal muscle relaxant, dantrolene, tobe
Climer, Amber D., Darsey, Jerry A., Fifer, E. Kim, Rayburn, Lori L., Robertson, Kevin S., Shaikh, Ali U.   +5 more
core   +1 more source

The medical management of cerebral palsy [PDF]

, 2016
Medical management of cerebral palsy is a complex issue that should be undertaken with the overall aim to improve comfort, function in every day life, self confidence, participation and independence. Although the main focus is commonly the motor disorder,
Kurian, MA, Smith, M
core   +1 more source

Measuring blood–brain barrier dysfunction: a critical appraisal of fluid biomarkers, in vitro models, in vivo imaging, and post‐mortem approaches

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract The blood–brain barrier (BBB) maintains central nervous system homeostasis by regulating molecular exchange between blood and brain. BBB dysfunction is associated with aging and neurological disorders such as Alzheimer's disease, stroke, and multiple sclerosis.
Shakira A. van der Panne, Helena Durrant, Jannis F. Heuer, Ivana Kancheva, Arno Stellingwerf, Lieuwe T. K. M. Verkaar, Damon Verstappen, Pascalle Mossel, Walter H. Backes, Erik N. T. P. Bakker, Jurgen A. H. R. Claassen, Marcel M. Verbeek, Louise van der Weerd, Matthias J. P. van Osch, Helga E. de Vries   +14 more
wiley   +1 more source

Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits [PDF]

, 2018
Hypertrophic cardiomyopathy (HCM) is a primary disorder of contractility in heart muscle. To gain mechanistic insight and guide pharmacological rescue, this study models HCM using isogenic pairs of human induced pluripotent stem cell-derived ...
Barriales-Villa, Roberto, Bhagwan, Jamie R., Denning, Chris, Eschenhagen, Thomas, Hansen, Arne, Harding, Sian E., Mannhardt, Ingra, Marston, Steve, Monserrat, Lorenzo, Mosqueira, Diogo, Owen, Thomas, Patel, Asha, Scott, Elizabeth, Smith, James G.w.   +13 more
core   +2 more sources

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

High‐Throughput Platform for Discovery of Chemical Inhibitors of Heat Shock Protein 70 (Hsp70): Adaptation for the Specialized Bacterial HscA–HscB–IscU Complex

Chemical Biology &Drug Design, Volume 107, Issue 3, March 2026.
The HscA–HscB–IscU system functions in iron–sulfur (Fe‐S) cluster biogenesis in bacteria and fungi, including pathogenic strains. Here, we describe a high‐throughput screen (HTS) to measure inorganic phosphate release from the ATPase HscA within this reconstituted, multi‐protein complex.
Arielle Shkedi, Aneta Grabinska‐Rogala, Jason Hernandez, Rafał Dutkiewicz, Jaroslaw Marszalek, Jason E. Gestwicki   +5 more
wiley   +1 more source