Results 71 to 80 of about 6,108 (207)

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah, Esther Zorio, Ana María Gómez   +2 more
wiley   +1 more source

Measuring blood–brain barrier dysfunction: a critical appraisal of fluid biomarkers, in vitro models, in vivo imaging, and post‐mortem approaches

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract The blood–brain barrier (BBB) maintains central nervous system homeostasis by regulating molecular exchange between blood and brain. BBB dysfunction is associated with aging and neurological disorders such as Alzheimer's disease, stroke, and multiple sclerosis.
Shakira A. van der Panne, Helena Durrant, Jannis F. Heuer, Ivana Kancheva, Arno Stellingwerf, Lieuwe T. K. M. Verkaar, Damon Verstappen, Pascalle Mossel, Walter H. Backes, Erik N. T. P. Bakker, Jurgen A. H. R. Claassen, Marcel M. Verbeek, Louise van der Weerd, Matthias J. P. van Osch, Helga E. de Vries   +14 more
wiley   +1 more source

Pharmacokinetics of dantrolene sodium in horses

The pharmacokinetics of dantrolene sodium were investigated in horses following both intravenous (2 mg/kg) and intragastric (4 mg/kg) administration.

core   +1 more source

Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes

, 2017
BACKGROUND Cardiac type 2 ryanodine receptors (RyR(2)s) Play a pivotal role in cellular electrophysiology and contractility. Increased RyR(2)-mediated diastolic sarcoplasmic reticulum (SR) Ca2+ release is linked to heart failure (HF) and arrhythmias ...
Schatter, Felix, Maier, Lars S., Renner, André, Herting, Jonas, Schotola, Hanna, Pabel, Steffen, Sossalla, Samuel, Hartmann, Nico, Danner, Bernhard C., Fischer, Thomas H., Frey, Norbert, Gummert, Jan, Hasenfuss, Gerd   +12 more
core   +1 more source

Heart Failure: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 3, March 2026.
This article takes calcium homeostasis as the point of departure to provide an overview of heart failure from three perspectives—epidemiology, pathophysiological mechanisms, and management strategies—and summarizes the current unmet needs and future directions in the field. ABSTRACT Heart failure (HF) is one of the leading causes of hospitalization and
Yujian Fan, Zhihua Yang, Qing Li, Meng Sun, Yumeng Pu, Ke Zhao, Yu Bao, Xianliang Wang, Jingyuan Mao, Zhiqiang Zhao   +9 more
wiley   +1 more source

High‐Throughput Platform for Discovery of Chemical Inhibitors of Heat Shock Protein 70 (Hsp70): Adaptation for the Specialized Bacterial HscA–HscB–IscU Complex

Chemical Biology &Drug Design, Volume 107, Issue 3, March 2026.
The HscA–HscB–IscU system functions in iron–sulfur (Fe‐S) cluster biogenesis in bacteria and fungi, including pathogenic strains. Here, we describe a high‐throughput screen (HTS) to measure inorganic phosphate release from the ATPase HscA within this reconstituted, multi‐protein complex.
Arielle Shkedi, Aneta Grabinska‐Rogala, Jason Hernandez, Rafał Dutkiewicz, Jaroslaw Marszalek, Jason E. Gestwicki   +5 more
wiley   +1 more source

Impairment of Glucose Uptake Induced by Elevated Intracellular Ca²⁺ in Hippocampal Neurons of Malignant Hyperthermia-Susceptible Mice

Cells
Malignant hyperthermia (MH) is a genetic disorder triggered by depolarizing muscle relaxants or halogenated inhalational anesthetics in genetically predisposed individuals who have a chronic elevated intracellular Ca2+ concentration ([Ca2+]i) in their ...
Arkady Uryash, Alfredo Mijares, Jose A. Adams, Jose R. Lopez   +3 more
doaj   +1 more source

Dantrolene sodium이 적혈구의 calcium이동에 미치는 영향

, 1984
의학과/박사[영문] [한글] Dantrolene sodium은 malignant hyperthermia를 유발하는 근강직(muscle spasticity)의 치료에 널리 사용되고 있는 골격근 이완제로써 그 작용방식은 sarcoplasmic reticulum에 서 calcium의 유리를 억제하여 excitation-contraction coupling과정을 방해함으로써 근 육수축을 감소시키는 것으로 보고되었다.
노용수
core  

Selective inhibition of glucose-stimulated insulin release by dantrolene

, 1982
Dantrolene sodium, which interferes with excitation-contraction coupling by inhibiting the Ca2+ release from sarcoplasmic reticulum in muscle, was used to investigate the role of stored calcium in the stimulation of insulin release by various ...
C. B. Wollheim, G. W. Sharp, D. Janjic
core   +1 more source

Dantrolene-Associated Hepatitis

, 1977
A patient with dantrolene-associated hepatitis is reported. Clinical features, laboratory findings, and results of a liver biopsy are discussed and compared to other cases appearing in the literature.
Russell F. Hanson, Sharon R. Lundin, Donald L. Uden   +2 more
core   +1 more source