Results 91 to 100 of about 6,108 (207)

In vitro binding of dantrolene to bovine serum albumin and rabbit red blood cell ghosts

, 1982
The binding of dantrolene to rabbit red blood cell (RBC) ghosts and bovine serum albumin as models of receptor sites was studied using fluorescence techniques.
M. Mahmoudian, A. R. Dehpour
core   +1 more source

Sub-chronic dantrolene treatment normalizes PPF in 3xTg-AD mice.

, 2013
PPF was measured at an interstimulus interval of 50 ms. (A–B) Bar graphs show paired pulse ratio from: (A) Saline-treated NonTg (n = 5) and 3xTg-AD (n = 8) mice with bath application of 10 µM dantrolene; (B) Sub-chronic dantrolene-treated NonTg (n = 12 ...
Megan B. Miller (292322), Benjamin G. Cameransi (292337), Joyce Kim (292328), Corinne Schneider (292326), Jill C. Richardson (292333), Ivan Goussakov (292324), Jaime Wicks (292331), Shreaya Chakroborty (292318), Vincent Conklin (292335), Clark Briggs (292320), Grace E. Stutzmann (292339)   +10 more
core   +1 more source

Dantrolene blocks intracellular calcium release in smooth muscle: competitive antagonism of thromboxane A₂

, 1978
Dantrolene sodium has been shown to block the release of intracellular calcium in skeletal muscle. It has been proposed that dantrolene blocks the movement and (or) action of a natural calcium ionophore.
S. C. Cunnane, M. Karmazyn, R. A. Karmali, D. F. Horrobin, M. S. Manku, R. O. Morgan, A. I. Ally   +6 more
core   +1 more source

Blood brain barrier (BBB) inhibitors, nimodipine and elacridar, had no effect on dantrolene passage.

, 2020
After 20 minutes of internasal administration of dantrolene (5mg/kg), in the presence or absence of BBB pump inhibitors (P-gp/BCRP), nimodipine (Nim, 2mg/kg) or elacridar (Elac, 10mg/kg) dissolved in the same vehicle as Ryanodex, the dantrolene brain ...
Yun Shi (172065), Huafeng Wei (333273), Shuchun Yu (782080), Yan Wang (15435), Qingcheng Meng (8561451), Ge Liang (578601), Jintao Wang (8051), Maryellen F. Eckenhoff (8561454)   +7 more
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Dantrolene paradoxically exacerbates short-term brain glucose hypometabolism, hippocampal damage and neuroinflammation induced by status epilepticus in the rat lithium-pilocarpine model

Status epilepticus (SE) is a neurologic emergency characterized by prolonged or rapidly recurring seizures. Increased intracellular calcium concentration ([Ca2+]i) occurring after SE is a key mediator of excitotoxicity that contributes to the brain ...
Gómez Oliver, Francisca, Fernández de La Rosa, Rubén, García García, Luis, Pozo García, Miguel Ángel   +3 more
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Effect of dantrolene on baseline cardiac haemodynamics (mean ± SD).

, 2018
Effect of dantrolene on baseline cardiac haemodynamics (mean ± SD).
Min Ru Qui (5851712), Kumud K. Dhital (5851715), Ling Gao (429702), Mark Hicks (5851706), Aoife Doyle (5851709), Peter S. Macdonald (277595), Andrew Jabbour (5851718), Hong C. Chew (5851703), Jeanette E. Villanueva (5851700)   +8 more
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Post-Anesthesia Cognitive Dysfunction in Mice Is Associated with an Age-Related Increase in Neuronal Intracellular [Ca²⁺]—Neuroprotective Effect of Reducing Intracellular [Ca²⁺]: In Vivo and In Vitro Studies

Cells
Background: Postoperative cognitive dysfunction (POCD) is a common disorder after general anesthesia in elderly patients, the precise mechanisms of which remain unclear.
Arkady Uryash, Alfredo Mijares, Carlos E. Lopez, Jose A. Adams, Paul D. Allen, Jose R. Lopez   +5 more
doaj   +1 more source

Dantrolene treatment reduces amyloid load in AD mice.

, 2013
(A) Representative 4G8-immunostained tissue from saline-treated (left) and dantrolene-treated (right) 6-month old TASTPM mice demonstrate an approximate 45% reduction in amyloid density with dantrolene treatment.
Megan B. Miller (292322), Benjamin G. Cameransi (292337), Joyce Kim (292328), Corinne Schneider (292326), Jill C. Richardson (292333), Ivan Goussakov (292324), Jaime Wicks (292331), Shreaya Chakroborty (292318), Vincent Conklin (292335), Clark Briggs (292320), Grace E. Stutzmann (292339)   +10 more
core   +1 more source

Dantrolene and suxamethonium [PDF]

Anaesthesia, 1980
openaire   +3 more sources

Calcium-directed therapy in acute pancreatitis

Медицина неотложных состояний
Background. Acute pancreatitis (AP) is a common and potentially life-threatening disease with high rates of complications and mortality. One of its key pathogenic mechanisms is disruption of calcium homeostasis in pancreatic acinar cells.
С.М. Чуклін, С.С. Чуклін
doaj   +1 more source