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Dantrolene : From Malignant Hyperthermia to Alzheimer’s Disease
CNS and Neurological Disorders - Drug Targets, 2020 Dantrolene, a ryanodine receptor antagonist, is primarily known as the only clinically acceptable and effective treatment for Malignant Hyperthermia (MH).
Huafeng Wei
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Dantrolene requires Mg 2+ to arrest malignant hyperthermia
Proceedings of the National Academy of Sciences of the United States of America, 2017 Malignant hyperthermia (MH) is a clinical syndrome of skeletal muscle that presents as a hypermetabolic response to volatile anesthetic gases, where susceptible persons may develop lethally high body temperatures.
Xaver Koenig, Bradley Launikonis
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British Journal of Anaesthesia, 2020 Faced with a malignant hyperthermia crisis, the immediate access to sufficient dantrolene is essential to achieve the best possible outcome for the patient.
Stephan Johannsen, Thierry Girard
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Anaesthesia, 1979
A single oral dose of dantrolene (100--150 mg) given at least 2 hr pre-operatively has been found to reduce significantly the strength of muscular fasciculations, the hyperkalaemia and the incidence of muscle pains following suxamethonium (from 56 to 4%) in a series of forty-eight patients compared with controls.
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A single oral dose of dantrolene (100--150 mg) given at least 2 hr pre-operatively has been found to reduce significantly the strength of muscular fasciculations, the hyperkalaemia and the incidence of muscle pains following suxamethonium (from 56 to 4%) in a series of forty-eight patients compared with controls.
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Hyperkalemia after Dantrolene and Verapamil-Dantrolene Administration in Dogs
Anesthesia & Analgesia, 1988The concurrent administration of dantrolene and verapamil has the theoretical advantage of being more efficacious than dantrolene alone in the treatment of malignant hyperthermia. However, the combination has been reported to cause fatal hyperkalemia in pigs.
A C, San Juan, K C, Wong, J D, Port
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