Results 61 to 70 of about 1,955 (161)
Molecular Aspects Implicated in Dantrolene Selectivity with Respect to Ryanodine Receptor Isoforms
, 2023 Dantrolene is an intra-cellularly acting skeletal muscle relaxant used for the treatment of the rare genetic disorder, malignant hyperthermia (MH).
Jana Gaburjakova, Marta Gaburjakova
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Successful management of malignant hyperthermia without dantrolene: A case report
Journal of International Medical ResearchMalignant hyperthermia during surgery represents a significant challenge for anesthesiologists due to its high mortality rate and the risk of long-term physiological damage.
Cailing Zhang +3 more
doaj +1 more source
Dantrolene and lymphocytic lymphoma [PDF]
Postgraduate Medical Journal, 1980 Summary A patient is reported who was on prolonged treatment with dantrolene for spastic paraplegia; he developed a malignant lymphoma which led to his death.
H H, Wan, J S, Tucker
openaire +2 more sources
Advanced Science, Volume 13, Issue 36, 29 June 2026.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Pharmacokinetics of dantrolene sodium in horses
The pharmacokinetics of dantrolene sodium were investigated in horses following both intravenous (2 mg/kg) and intragastric (4 mg/kg) administration.
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Caffeine and dobutamine challenge induces bidirectional ventricular tachycardia in normal rats
Heart Rhythm O2, 2020 Background: Bidirectional ventricular tachycardia (BD-VT) is an intriguing arrhythmia, characterized by a beat-to-beat alternation of the QRS polarity on electrocardiogram. Currently there is no simple BD-VT animal model.
Chenyu Zhang, BS, Youhua Zhang, MD, PhD
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Physiological Reports, Volume 14, Issue 11, June 2026.Abstract Despite the ubiquitous use of monosodium glutamate (MSG) as a food additive, its specific effects on intestinal health and disease remain largely unclear. Here we found mucosal application of MSG induced an upward intestinal short‐circuit current (Isc) in the murine ileum, which was significantly reduced by extracellular Cl−, Na+, and Ca2 ...
Yunxian Wang +4 more
wiley +1 more source
Unmasking malignant hyperthermia: a rapid response to a hypermetabolic crisis: case report
Frontiers in AnesthesiologyIntroductionMalignant Hyperthermia is a rare, life-threatening pharmacogenetic disorder that can occur after exposure to triggering anesthetic agents, including volatile anesthetics and succinylcholine.Case presentationAn 18-year-old male with multiple ...
En Chang +5 more
doaj +1 more source
ChemSusChem, Volume 19, Issue 9, 14 May 2026.A Safe and Sustainable by Design (SSbD) mechanochemical approach was used to prepare a marketed sweetener from a biomass derivative used in flavoring industry. A personal care ingredient was also synthesized. The study also evaluated and compared the reactivity in of polymeric jars with that in of common conventional stainless steel or and zirconium ...
Rubén Solórzano‐Rodríguez +6 more
wiley +1 more source
Dantrolene Inhibits Human Erythrocyte Glutathione Reductase
, 2008 Dantrolene, a drug used to treat malignant hyperthermia, inhibits abnormal Ca2+ release from the sarcoplasmic reticulum. Glutathione reductase (Glutathione: NADP+ oxidoreductase, EC 1.8.1.7), a member of the pyridine-nucleotide disulfide oxidoreductase ...
Ciftci, Mehmet +3 more
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